期刊
GREEN CHEMISTRY
卷 12, 期 9, 页码 1599-1606出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c002967j
关键词
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资金
- Ministerio de Ciencia e Innovacion [CTQ2007-62771/BQU, CSD2007-00006]
- Generalitat Valenciana [PROMETEO/2009/039]
- University of Alicante
The immobilization of N-sulfonyl-(R-a)-binam-D-prolinamide using polystyrene as a support allows the recovery of an efficient catalytic system for the enantioselective direct aldol reaction between different ketones and aldehydes under solvent-free or aqueous conditions. The polystyrene-supported N-sulfonyl-(R-a)-binam-D-prolinamide catalyst in combination with benzoic acid showed similar results to those obtained with unsupported N-tosyl-binam-derived prolinamide under similar reaction conditions. The aldol products were obtained at room temperature and using only 2 equivalents of the ketone with high yields, regio-, diastereo- and enantioselectivities. The aldol reaction between aldehydes can also be performed under these reaction conditions with moderate results. The recovered catalyst can be reused up to six times without having a detrimental effect on the achieved results.
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