Article
Chemistry, Organic
Shuangshuang Li, Ju Qiu, Bowen Li, Zuolian Sun, Peizhong Xie, Teck-Peng Loh
Summary: A practical palladium/calcium catalytic system was developed for dehydrative allylation with unactivated allylic alcohols, utilizing ethanol solvent with a water additive to accelerate proton transfer. This system allowed for smooth reactions at room temperature, producing allylic compounds with a variety of functional groups in high to excellent yields.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Yongke Hu, Lei Chen, Gulou Shen, Jin Li, Shaozhong Li, Huaju Li, Yanxing Li
Summary: An efficient catalytic system for the oxidation of alcohols to aldehydes/ketones has been developed, using catalytic amounts of Bi(NO3)(3) and Keto-ABNO with air as the oxidant. Various alcohols were smoothly oxidized to the corresponding products under mild conditions, achieving satisfactory yields without the use of a ligand or base.
Article
Chemistry, Multidisciplinary
Sylvain Lemaitre, Anne-Lise Romain, Francois Bariere, Anthony Craquelin, Chloe Copin, Alexandre Jean
Summary: In the pharmaceutical industry, the development of a safe, cost-effective, productive, and sustainable process is crucial to minimize the negative environmental impact caused by the large-scale use of reagents and solvents. This study presents the successful replacement of a toxic and expensive oxidant with a highly efficient, selective, and environmentally friendly catalytic system for the oxidation of a benzylic primary alcohol in the manufacturing route of a clinical candidate. The implementation of this atom economical and low-cost aerobic oxidation at the pilot scale resulted in the production of a high-quality key intermediate.
Article
Chemistry, Multidisciplinary
Tien Tan Bui, Hee-Kwon Kim
Summary: A practical one-pot synthesis of ketones from primary alcohols was successfully performed using dibromoisocyanuric acid and various aromatic compounds in the presence of Fe2O3. This method provides an efficient and useful approach to synthesize aromatic ketones from primary alcohols under mild reaction conditions, yielding high amounts of products.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Changjian Zhou, Rong Sun, Yuting Zhang, Biao Xiong, Hui Dai, Yong Dai
Summary: A stable, earth-abundant, reusable cobalt-based heterogeneous catalyst has been developed for the oxidative esterification of alcohols, showing good to excellent product yields with broad substrate scope. The catalyst can be easily recycled up to five times without significant loss of efficiency, with the active sites proposed to be Co-N species.
Article
Chemistry, Multidisciplinary
S. Saeid Saei Dehkordi, Jalal Albadi, Abbas Ali Jafari, Heshmat Allah Samimi
Summary: A copper-based magnetic nanocatalyst was prepared by co-precipitation method and showed good activity for the aerobic oxidation of various alcohols in water. It can be recycled up to five times with minimal loss of catalytic activity through simple filtration.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Chemistry, Multidisciplinary
Yang Peng, Yang Huang, Teng Li, Nianxin Rong, Haiwei Jiang, Hexian Shi, Weiran Yang
Summary: This study presents a highly efficient method for alcohol disproportionation catalyzed by iodide under acidic conditions, which can generate alkanes and aldehydes/ketones with high functional group tolerance. The optimized reaction conditions allows for simultaneous high yields of desired products and the involvement of radical intermediates in the reaction mechanism.
Review
Chemistry, Physical
Yuheng Jiang, Siyang Li, Xiaoyu Fan, Zhiyong Tang
Summary: Photocatalytic methane conversion is a promising strategy to utilize natural gas and renewable energy. Among them, aerobic photocatalytic methane conversion using molecular oxygen as oxidant has attracted much attention. This review classifies it into aerobic photocatalytic partial oxidation of methane (APPOM) and aerobic photocatalytic coupling of methane (APCM), and focuses on the fundamentals of oxygen activation and methane reaction modes. Finally, a brief summary of current challenges and future prospects for aerobic photocatalytic methane conversion is provided.
Article
Chemistry, Organic
Aline A. N. de Souza, Aloisio de A. Bartolomeu, Timothy J. Brocksom, Timothy Noel, Kleber T. de Oliveira
Summary: The electrochemical sulfenylation reaction was investigated in both batch and continuous flow regimes, with quaternary ammonium salts identified as the best mediators. The tolerance of Boc-cysteine to the reaction protocol was noted, increasing its relevance. The methodology was found to be scalable in both batch and continuous flow conditions, offering potential for further studies involving important functional groups in organic synthesis.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Hui Liu, Hai-Yang Yu, Jia-Ying Huang, Ji-Hu Su, Can Xue, Xian-Tai Zhou, Yao-Rong He, Qian He, De-Jing Xu, Chao Xiong, Hong-Bing Ji
Summary: In this study, a biomimetic approach for the aerobic oxidation of C-sp(3)-H bonds was developed, which showed excellent efficiency and mild reaction conditions. The Cu-I-radical intermediate species generated from the catalyst played a critical role in the reaction rate, and the PINO mechanism was demonstrated for the C-sp(3)-H bond oxidation.
Article
Chemistry, Multidisciplinary
Daisuke Uraguchi, Kohsuke Kato, Takashi Ooi
Summary: An o-quinone methide (o-QM) with an overcrowded olefinic framework is introduced, showing dehydridation activity due to its enhanced zwitterionic character, especially under photoexcitation. Experimental analysis and density functional theory calculations provide mechanistic insights, revealing that the o-QM operates in dehydridative catalysis for the oxidation of benzylic secondary alcohols.
Article
Chemistry, Organic
Yi Deng, Shi-Chao Lu, Lu-Lu Yue, Ya-Ling Gong, Xi-Dong Guan
Summary: An effective method for selectively oxidizing benzylic and allylic alcohols, including those deactivated by electron-withdrawing groups, was described using hypervalent iodine (III)/catalytic DDQ under mild conditions. This metal-free reaction provides a green approach to the synthesis of corresponding carbonyl compounds. The methodology has potential applications in organic synthesis and pharmaceutical chemistry.
SYNTHETIC COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Yu Tang, Yuting Li, Franklin (Feng) Tao
Summary: Scientists worldwide have made significant progress in catalytic transformations of CH4 to chemicals under mild conditions, although challenges remain. Academic research has developed numerous reactions for converting CH4 to oxygenates at relatively low temperatures, but a molecular-level understanding in complex reaction environments under mild conditions is still lacking.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Physical
Xin Liu, Hong Ma, Meiyun Zhang, Penghua Che, Yang Luo, Shujing Zhang, Jie Xu
Summary: A Co-N-C nanomaterial composed of CoN4 sites on graphitic carbon nitride was constructed to achieve self-cascade activation of O-2 in water, guiding the generation of hydroxyl radicals (OH•) in a controlled manner. This material exhibited highly selective oxidation properties, allowing efficient synthesis of various organic acids from furan alcohols, aromatic alcohols, and fatty alcohols under mild conditions. The study demonstrated the promising utility of O-2 in a low energy-consuming way, independent of light or electricity.
Article
Chemistry, Organic
Jie Li, Xinhui Zhang, Yisen Yao, Yapei Gao, Wen Yang, Wanxiang Zhao
Summary: An efficient palladium-catalyzed Suzuki-Miyaura cross-coupling reaction has been developed for the synthesis of oxygen atom-substituted allylboronates with aryl/vinyl bromides, iodides, and triflates. This protocol offers a broad substrate scope, excellent functional group tolerance, and easy gram-scale preparation, providing an alternative approach for the synthesis of allylic alcohols and their derivatives.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Angelo Cichelli, Ylenia Riciputi, Lorenzo Cerretani, Maria F. Caboni, Nicola d'Alessandro
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Gloria Formoso, Caterina Pipino, Maria Pompea Antonia Baldassarre, Piero Del Boccio, Mirco Zucchelli, Nicola D'Alessandro, Lucia Tonucci, Angelo Cichelli, Assunta Pandolfi, Natalia Di Pietro
APPLIED SCIENCES-BASEL
(2020)
Article
Chemistry, Multidisciplinary
Giuseppe Scioli, Lucia Tonucci, Pietro Di Profio, Antonio Proto, Raffaele Cucciniello, Nicola d'Alessandro
SUSTAINABLE CHEMISTRY AND PHARMACY
(2020)
Article
Chemistry, Applied
Sara Pantalone, Lucia Tonucci, Angelo Cichelli, Lorenzo Cerretani, Ana Maria Gomez-Caravaca, Nicola d'Alessandro
Summary: The study found that phenolic compounds from olive by-products can reduce the acrylamide content in food, with tyrosyl acetate showing the best inhibitory performance.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Chemistry, Applied
Francesca Pietropaoli, Sara Pantalone, Angelo Cichelli, Nicola d'Alessandro
Summary: This review aims to reveal the toxicological characteristics of AA, describe the most interesting mitigation techniques for each food category, and focus on compliance with EU legislation in various consumer products in Europe.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Chemistry, Multidisciplinary
Andrea Mascitti, Giuseppe Scioli, Lucia Tonucci, Valentino Canale, Raimondo Germani, Pietro Di Profio, Nicola d'Alessandro
Summary: The deoxydehydration reaction of glycerol and 1,2-propanediol in ionic liquids catalyzed by methyltrioxorhenium (MTO) and Re2O7 was studied. The ability of ionic liquids to improve the catalytic performance of the rhenium catalyst was examined by conducting experiments using various cations and anions. The results showed that a specific anion, bis(trifluoromethylsulfonyl)imide (TFSI), and a cation with a single aromatic ring were more suitable for the reaction. The presence of ionic liquids also prevented the inertization process of the catalyst, allowing for the readdition of fresh polyol.
Article
Food Science & Technology
Michele Ciulla, Valentino Canale, Rafal Damian Wolicki, Vincenzo Ferrone, Giuseppe Carlucci, Antonella Fontana, Gabriella Siani, Nicola D'Alessandro, Pietro Di Profio
Summary: This paper compares extraction methods using subcritical solvents, dimethyl ether (sC-DME) and n-butane (sC-nB), and finds that sC-DME exhibits higher selectivity and better yield for caffeine. It also discusses technical implementations to optimize subcritical solvent usage and demonstrates that extraction processes based on sub-critical solvents are easy to operate and efficient, and can be easily automated.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Lucia Tonucci, Andrea Mascitti, Anna M. Ferretti, Francesca Coccia, Nicola d'Alessandro
Summary: This study reports a pathway to obtain a bio-adipic acid using metal nanoparticles as catalysts for the hydrogenation reactions of dicarboxylic acids in water at room pressure and temperature. Among the metal nanoparticles tested, Rh NPs showed the best selectivity for adipic acid.
Article
Environmental Sciences
Fabio Girardi, Andrea Mascitti, Nicola D'Alessandro, Lucia Tonucci, Giuseppe Augusto Marzo, Romolo Remetti
Summary: This study aims to investigate the impact of the Fenton reaction, an oxidative treatment, on the biochemical methane potential of solid residues from olive oil production. The experiment reveals that the Fenton treatment improves the speed of methane production, reduces the bacteriostatic effect of phenols, decreases the H2S content in the produced biogas, and enhances methane production in the first four weeks of the test.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.
