Article
Biotechnology & Applied Microbiology
Lin Li, Yunfan Bai, Chuhua Qi, Yile Du, Xiaoxiao Ma, Yutong Li, Pingping Wu, Shuangli Chen, Sijing Zhang
Summary: A succinic anhydride-modified apple pomace (SAMAP) was synthesized to address environmental issues caused by the accumulation of apple pomace and effectively treat heavy metal ions. SAMAP exhibited high adsorption capacity for Cu(II) and Pb(II), suggesting its potential application in wastewater treatment.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Hemi Cumming, Susan N. Marshall
Summary: The study focused on the synthesis of glyceryl caffeate esters and their effectiveness in protecting soybean oil from oxidation, revealing that the esterification reaction in propylene carbonate solvent could be performed without the need for molecular sieves, with excellent product performance. Different chain lengths of glyceryl caffeate esters showed comparable antioxidant effectiveness in soybean oil, with compounds containing a single fatty ester being slightly more effective than those containing two fatty esters.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Babak Kaboudin, Rasul Pourbafarani, Sajedeh Alavi, Foad Kazemi, Hiroshi Aoyama
Summary: This report presents a simple method for acylation of aliphatic alcohols using succinic anhydride under neutral conditions without the need for any metal catalyst. The results show that the method can yield various acylated aliphatic alcohols in high yields. Additionally, a competitive experiment was conducted to investigate the selectivity of the reaction in the presence of CTAB.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yueting Xu, Yanfei Zhao, Fengtao Zhang, Yuepeng Wang, Ruipeng Li, Junfeng Xiang, Zhimin Liu
Summary: The alcoholysis of propylene oxide using azolate ionic liquids at room temperature results in high yields and excellent selectivity due to the cooperative hydrogen-bonding interactions between the anion and methanol, as well as between the cation and PO.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Bozhi Tan, Yao Li, Xu Fei, Jing Tian, Longquan Xu, Yi Wang
Summary: The synthesis efficiency and side reactions of Octenyl succinic anhydride (OSA) starch can be improved by using lipase immobilized on polydopamine magnetic hydrogel microspheres (PMHM) as a biocatalyst. The prepared L-PMHM can be uniformly dispersed in starch slurry, leading to full contact between lipase and starch. L-PMHM exhibits better affinity to the substrate and achieves a higher degree of substitution compared to free lipase. Moreover, L-PHMM can maintain its activity after multiple reuses and can be easily separated from the product.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Safaa Ragab, Amany El Sikaily, Ahmed El Nemr
Summary: This study aimed to synthesize cellulose di-acetate using a solvent-free acetylation system with Giza 86 cotton cellulose, Ac2O, and NiCl2 center dot 6HO as a new catalyst. Both reflux and microwave irradiation methods were employed. The study also demonstrated the preparation of a dialysis membrane using the synthesized cellulose di-acetate. The microwave irradiation method showed excellent yields and short reaction time, making it a promising approach.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Reyhaneh Taherinia, Hemayat Shekaari, Masumeh Mokhtarpour
Summary: Solubility is a crucial property in drug discovery and development, and adding a co-solvent to aqueous solutions is a widely used method in the pharmaceutical industry. Protic ionic liquids (PILs) have emerged as a low-cost and environmentally friendly solvent for improving drug solubility. This research investigated the effect of PILs containing specific cations and anions on the solubility of acetaminophen (ACP), and found that higher concentrations and temperatures of PILs led to increased ACP solubility. The e-NRTL model was found to be more accurate in fitting the solubility data. Thermodynamic functions of ACP dissolution, such as enthalpy, Gibbs free energy, and entropy, were estimated using the Gibbs and van't Hoff equations, revealing an endothermic dissolution process.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Sara Gracia-Barberan, Alejandro Leal-Duaso, Elisabet Pires
Summary: This microreview explores the potential of Deep Eutectic Solvents (DES) as alternatives to Ionic Liquids (ILs) in metal-catalysed reactions. The results show that DES have shown promising results in various reactions, but further research is needed to explore their applicability in other reactions and understand the influence of the nature of the DES. The study also introduces bio-based ionic liquids as a complementary solvent to DES for fully replacing traditional ILs.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xingben Wang, Frederic W. Patureau
Summary: The highly selective synthesis of mono- and di-2-fluoroallylic amines from gem-difluorocyclopropanes and primary anilines using a Pd catalyst is described. Initial kinetic studies suggest a first order reaction with the gem-difluorocyclopropane substrate and a zeroth order reaction with the aniline coupling partner. The newly synthesized fluoroallylic motifs have important applications in synthetic and medicinal chemistry, and can potentially stimulate the development of coupling methods using strained cyclic building blocks.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Anamika Sindhu, Meena Bisht, Indra Bahadur, Pannuru Venkatesu
Summary: This study synthesized different multicationic IL systems and found that an increase in cationic ratio improved the structural stability and activity of alpha-CT.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Automation & Control Systems
Tahir Mehmood, Mudassir Iqbal
Summary: This study investigated the extraction of lead and cobalt from wastewater using glycolamide based functionalized ionic liquids, and found that factors such as choice of IL, pH value, contact time, and metal ionic concentrations significantly influenced the extraction efficiency. Response surface methodology was used to optimize the extraction efficiency of ILs, and interaction between ILs and Pb (II) and Co (II) was confirmed through FTIR qualitative analysis.
JOURNAL OF CHEMOMETRICS
(2021)
Article
Chemistry, Multidisciplinary
Itoh Toshiyuki
Summary: The use of ILs as solvents and stabilizers for enzymes, specifically lipases, allows for the recyclable use of enzymes, acceleration of transesterification, and enhancement of enzyme stability and reaction activity. This IL engineering approach has a significant impact on lipase-catalyzed reactions and has the potential to improve enzyme capabilities.
Article
Biophysics
Hongbo Suo, Moju Li, Renmin Liu, Lili Xu
Summary: In this study, imidazolium-based ionic liquid was successfully grafted to magnetic polydopamine nanoparticles for lipase immobilization. The immobilized lipase showed excellent activity and stability, with increased affinity to substrate. Additionally, the immobilized lipase can be easily separated from the reaction system with a magnet, providing new ideas for further studies in this field.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Energy & Fuels
Xiu Xing, Zi-Wen Zhou, Yun-Jie Wei, Yan-Hong Liu, Kun Li, Xiao-Qi Yu, Na Wang
Summary: The process of jatropha oil transesterification for biodiesel production was studied using immobilized Rhizomucor miehei lipase (RML) in ionic liquids. The highest synthetic activity of immobilized RML was found in [BMIM][PF6], which was more than five times higher than the free enzyme. The immobilized enzyme showed good stability even after multiple reuses and storage at -20 degrees C for 98 days.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biochemistry & Molecular Biology
Zeping Lu, Mei Chen, Tongtong Jin, Binbin Nian, Yi Hu
Summary: Ionic liquids (ILs) are used as chemical modifiers to improve the efficiency, activity, and stability of enzymes. This study investigated the impact of ILs with different chain lengths on the enzymatic properties of Candida antarctica lipase B (CALB) and found that ILs significantly influenced CALB's absorption orientation. Molecular dynamics simulations showed that ILs with suitable chain lengths formed strong interactions with CNTs and ILs, stabilizing CALB's open state and improving its activity and stability. This study provides insights into the design of green modifiers for better immobilized enzymes and lays the groundwork for future research on IL modifiers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Energy & Fuels
Sandro L. Barbosa, Milton S. de Freitas, Wallans T. P. dos Santos, David Lee Nelson, Maria Betania de Freitas Marques, Stanlei Klein, Giuliano C. Clososki, Franco J. Caires, Eduardo J. Nassar, Lucas D. Zanatta, Foster A. Agblevor, Carlos A. M. Afonso, Adriano C. Moraes Baroni
Summary: Activated charcoal prepared by ZnCl2 activation can be used for the adsorptive purification of pretreated glycerol. The surface properties of the activated charcoal are suitable for increasing glycerol concentration effectively through gravity filtration at room temperature. The activated charcoal can be regenerated through washing and heating treatment for reuse.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Chemistry, Multidisciplinary
Rafael F. A. Gomes, Joao M. J. M. Ravasco, Kessia H. S. Andrade, Jaime A. S. Coelho, Rui Moreira, Rafael Oliveira, Fatima Nogueira, Carlos A. M. Afonso
Summary: In this study, 5-hydroxymethylfurfural (HMF) was identified as a key synthon for preparing highly complex cyclopentenones (CP) via tandem reactions. The synthesis involved the reaction of HMF with external O- and N-nucleophiles in delta-lactone-fused-CPs hotspots. The new enones showed activity against intraerythrocytic Plasmodium falciparum.
Article
Nanoscience & Nanotechnology
Teresa Esteves, Flavio A. . Ferreira, Ana Teresa Mota, Angel Sanchez-Gonzalez, Adria Gil, Kessia H. S. Andrade, Carlos A. . M. Afonso, Frederico Castelo Ferreira
Summary: In this study, molecularly imprinted polymers were designed using a computational chemistry approach to improve the purity and recovery of lupanine from lupin bean wastewater. The results demonstrate the potential application of this strategy in making the industrial process more sustainable.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Bruno M. Pedras, Carla Goncalves, Diogo R. Figueira, Pedro Simoes, Paula Goncalves, Alexandre Paiva, Susana Barreiros, Madalena Salema-Oom
Summary: This study successfully utilized non-structural sugars from white wine grape pomace as the carbon source for the production of multiple high-value products by Rhodotorula babjevae, highlighting its high biotransformation capability and fructophilic character.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Elisandra Scapin, Georgia C. Zimmer, Jean C. B. Vieira, Catarina A. B. Rodrigues, Carlos A. M. Afonso, Nilo Zanatta, Helio G. Bonacorso, Clarissa P. Frizzo, Marcos A. P. Martins
Summary: In this study, the synthetic potential of tetrazolo[1,5-a]pyrimidines to obtain new pyrimidine derivatives was explored via click chemistry and hydrogenation. Click chemistry reactions produced unprecedented trifluoromethylated triazolylpyrimidines with excellent yields. Hydrogenation reactions resulted in the formation of different pyrimidine compounds, with a preference for 2-aminopyrimidine formation. Photochemical hydrogenation was effective in reducing aryl-brominated substrates without dehalogenation.
JOURNAL OF FLUORINE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Lidia A. S. Cavaca, Jaime A. S. Coelho, Susana D. D. Lucas, Rui M. S. Loureiro, Rafael F. A. Gomes, Carlos A. M. Afonso
Summary: In this study, a tunable continuous flow hydrogenation method was used to selectively and stepwise synthesize novel bifunctionalized cyclopentanones with high yields and selectivity. The stability studies of the diamino cyclopentanone motif also led to the development of an elimination procedure for the synthesis of corresponding alpha-enaminones. Deuteration of the cyclopentene scaffold and the sequential synthesis of alpha-enaminones directly from furfural were also demonstrated. The methodology presented in this study is of great significance for the synthesis of ATP-sensitive potassium channel agonists.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Engineering, Chemical
Ricardo Correia, Maria Paula Duarte, Elisabete Muchagato Mauricio, Joao Brinco, Jose Carlos Quintela, Marco Gomes da Silva, Margarida Goncalves
Summary: The purpose of this study was to evaluate the recovery and characterization of bioactive extracts from Acacia dealbata leaves and twigs. The results showed that using 70% acetone solution for maceration extraction yielded the highest content of phenolics, flavonoids, and proanthocyanidins. The non-polar fraction of the extracts was mainly composed of phytol, squalene, alpha-tocopherol, lupenone, and lupeol. The extracts exhibited antioxidant and antimicrobial activities. The findings demonstrate the feasibility of recovering valuable components from these biomass fractions for further utilization in biorefinery.
Article
Food Science & Technology
Catarina Pereira, Davide Mendes, Nuno Martins, Marco Gomes da Silva, Raquel Garcia, Maria Joao Cabrita
Summary: This study aims to develop a sustainable method for correcting must acidity in winemaking, particularly in warm regions. The findings show that unripe grape must can be used to increase acidity in wines without negatively impacting their characteristics. This discovery is of great significance for circular economy and wine production.
Article
Chemistry, Applied
Joao R. Vale, Milene A. G. Fortunato, Kessia H. S. Andrade, angelo M. R. Rocha, Carlos A. M. Afonso, Filipa Siopa
Summary: (-)-Agelastatin A was synthesized by a flow photorearrangement of a pyridinium salt, which enabled the one-step construction of the desired cyclopentene core with specific functionalities and relative configurations. The enantiopure precursor to the natural product was obtained through a flow enzymatic kinetic resolution of the resulting bicyclic vinyl aziridine. This total synthesis utilized a single protective group. Two novel agelastatin N3-derivatives were synthesized and their cytotoxicity against various cancer cell lines was evaluated, confirming the significance of unsubstituted N3 in the biological activity of (-)-agelastatin A.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Mario R. C. Soromenho, Carlos A. M. Afonso, Jose M. S. S. Esperanca
Summary: This study presents the design and synthesis of a series of photochromic gemini diarylethene-based ionic liquids (GDILs) with different cationic motifs. Various synthetic pathways were optimized to produce cationic GDILs with chloride as the counterion. These novel salts exhibit surprising water solubility and unexplored photochromic features, expanding their potential applications. The physicochemical properties of GDILs in aqueous and imidazolium-based ionic liquid (IL) solutions were investigated, revealing photoinducible changes in conductivity and other properties upon UV irradiation. The electronic and conformational changes associated with these innovative stimuli GDILs offer new opportunities for their use as photoswitchable materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Rafael F. A. Gomes, Joao R. Vale, Juliana G. Pereira, Carlos A. M. Afonso
Summary: This research aims to synthesize naturally occurring compounds with biologically active aminocyclopentanes and prepare a versatile synthon for total synthesis with orthogonal protection of amines. Mixed trans-4,5-diaminocyclopentenones were formed by reacting furfural and two amines using Cu-(OTf)(2) as a catalyst. The selected amines can be selectively deprotected, enabling selective modification of amines on the cyclopentane core. The significance of this research is demonstrated by the successful total synthesis of highly complex (+/-)-Agelastatin A.
Article
Food Science & Technology
Catia V. Almeida Santos, Catarina Pereira, Nuno Martins, Maria Joao Cabrita, Marco Gomes da Silva
Summary: This study investigated the effect of different doses of SO2 on the profiles of VOCs and AAs in two white wines during aging. The results showed that the addition of SO2 had a minimal impact on both VOCs and AAs. Additionally, the blend wine was less affected by SO2 doses and aging time compared to the varietal wine.
Article
Chemistry, Applied
Vitor Rosa, Helena Laronha, Clara S. B. Gomes, Cristina M. Cordas, Joao Brinco, Flavia Freitas, Marco D. R. Gomes da Silva, Teresa Aviles
Summary: A new neutral dimeric Ar-BIAN Cu(I) complex was synthesized and its structure and electrochemical properties were studied. The complex exhibited good catalytic activity in the oxidation of benzylic alcohols. Rating: 8 points
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Liane Meneses, Asiyah Esmail, Mariana Matos, Chantal Sevrin, Christian Grandfils, Susana Barreiros, Maria A. M. Reis, Filomena Freitas, Alexandre Paiva
Summary: This study evaluated the use of subcritical water as a greener alternative for PHA recovery from microbial cells. It was found that combining subcritical water treatment with hypochlorite digestion can significantly improve the purity of PHA, although some depolymerization of the biopolymer occurred during the process.
BIOENGINEERING-BASEL
(2022)
Review
Chemistry, Multidisciplinary
Marina Ciriani, Rudi Oliveira, Carlos A. M. Afonso
Summary: This review article covers the main topics and applications of semi-continuous and continuous chiral separation, focusing on preferential crystallization, membrane separations, and continuous chromatography. It also offers an authors' perspective on potential future directions in the field.
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.