Article
Biochemistry & Molecular Biology
Anri Nishinaka, Miruto Tanaka, Kota Aoshima, Aika Kuriyama, Takahiro Sasaki, Wataru Otsu, Hiroto Yasuda, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
Summary: This study investigated the involvement of neovascular glaucoma (NVG) in retinal ischemic disease using a murine model. The findings suggest that the formation of NVG may be correlated with the pathological symptoms of retinal ischemic disease, possibly through changes in vascular endothelial growth factor (VEGF) and fibrosis-related factor expression.
Review
Biochemistry & Molecular Biology
Federico Di Staso, Mariachiara Di Pippo, Solmaz Abdolrahimzadeh
Summary: This review aims to elucidate the possible origins of choroidal neovascularization (CNV) by examining in vivo and in vitro models compared to clinical cases. It pays particular attention to histologic alterations and molecular cascades. Although the mechanisms are still partially obscure, experimental models are progressively enhancing our understanding of neovascularization etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Migyeong Yang, Jinyoung Han, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Jeewoo Yoon, Seong Choi, Gyudeok Hwang, Daniel Duck-Jin Hwang
Summary: This study aimed to develop an artificial intelligence (AI) model to predict visual acuity in patients with myopic choroidal neovascularization (mCNV). The models achieved high performance by incorporating various data, including optical coherence tomography (OCT) images and post-injection data. The AI models could assist in predicting visual prognosis and evaluating treatment outcomes in patients with mCNV.
Article
Ophthalmology
Ananth Sastry, Christine Ryu, Xuejuan Jiang, Hossein Ameri
Summary: This study aimed to identify predictive factors for the development of neovascular glaucoma (NVG) in eyes with anterior segment neovascularization without glaucoma (ASNVWG), as well as poor visual outcomes in eyes that have already developed NVG. The results showed that retinal vein occlusion (RVO), presenting visual acuity, and concurrent traction retinal detachments (TRDs) were risk factors for NVG in eyes with ASNVWG. In eyes with NVG, RVO and concurrent vitreous hemorrhage were risk factors for vision ≤20/200 at 6 months, whereas treatment with ≥1 panretinal photocoagulation (PRP) or intravitreal bevacizumab (IVB) within 1 week of presentation, or ≥3 treatments of PRP or IVB within 6 months, were protective factors.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiaojiao Pang, Feng Xu, Gianmarco Aondio, Yu Li, Alberto Fumagalli, Ming Lu, Giuseppe Valmadre, Jie Wei, Yuan Bian, Margherita Canesi, Giovanni Damiani, Yuan Zhang, Dexin Yu, Jun Chen, Xiang Ji, Wenhai Sui, Bailu Wang, Shuo Wu, Attila Kovacs, Miriam Revera, Hao Wang, Xu Jing, Ying Zhang, Yuguo Chen, Yihai Cao
Summary: In this single-arm clinical trial, the authors show that treatment of COVID-19 patients with bevacizumab, an anti-vascular endothelial growth factor drug, can improve PaO2/FiO(2) ratios and oxygen-support status. Relative to an external control group, bevacizumab shows clinical efficacy by improving oxygenation.
NATURE COMMUNICATIONS
(2021)
Review
Physiology
Xueli Liu, Bin Zhu, Yujie Li, Xinyue Liu, Sheng Guo, Chenglong Wang, Sen Li, Dingxuan Wang
Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Hyung Bin Hwang, Na Young Lee
Summary: The study found that AGVI with adjuvant bevacizumab had a higher success rate compared to AGVI alone, but there was no significant difference in intraocular pressure reduction percentage.
Article
Medicine, Research & Experimental
Masaru Inatani, Tomomi Higashide, Kenji Matsushita, Atsuya Miki, Mari Ueki, Yuji Iwamoto, Masato Kobayashi, Sergio Leal
Summary: The VEGA trial demonstrated that IVT-AFL could significantly improve IOP control in patients with neovascular glaucoma, suggesting it as a potential treatment option for this condition.
ADVANCES IN THERAPY
(2021)
Article
Multidisciplinary Sciences
Koichi Nishitsuka, Akira Sugano, Takayuki Matsushita, Katsuhiro Nishi, Hidetoshi Yamashita
Summary: This study evaluated the long-term outcomes of primary Baerveldt glaucoma implant (BGI) surgery for neovascular glaucoma. The results showed significantly reduced intraocular pressure and decreased number of glaucoma medications postoperatively, with a visual acuity improvement rate of 56.0% and low complication rates.
Article
Biochemistry & Molecular Biology
Tamar Azrad-Leibovich, Alon Zahavi, Moran Friedman Gohas, Myles Brookman, Orit Barinfeld, Orkun Muhsinoglu, Shalom Michowiz, Dror Fixler, Nitza Goldenberg-Cohen
Summary: In this study, diabetic retinopathy in two mouse models and the response to anti-VEGF injection were characterized. The results showed significant retinal vasculopathy and increased retinal thickness in diabetic mice, along with changes in gene expression related to diabetes. Anti-VEGF treatment reduced retinal thickness. Therefore, the study found that mouse models can facilitate the development of treatment modalities for diabetic retinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Masaru Inatani, Tomomi Higashide, Kenji Matsushita, Daisuke Nagasato, Hitoshi Takagi, Mari Ueki, Yasuyuki Takai, Ken Miyazaki, Yuji Iwamoto, Masato Kobayashi, Sergio Leal
Summary: The study evaluated the efficacy of IVT-AFL in treating neovascular glaucoma in Japanese patients, showing significant reductions in intraocular pressure and improvements in neovascularization without the need for systemic IOP-lowering drugs or panretinal photocoagulation.
ADVANCES IN THERAPY
(2021)
Article
Ophthalmology
Han Joo Cho, Sang Min Park, Jaemin Kim, Seung Kwan Nah, Jihyun Lee, Dong Won Lee, Jong Woo Kim
Summary: The study found significant differences in the progression of macular atrophy (MA) among neovascular age-related macular degeneration (AMD) subtypes. The risk of foveal involvement in MA was associated with baseline factors or phenotype of neovascular AMD, rather than with the frequency of anti-VEGF injections.
ACTA OPHTHALMOLOGICA
(2021)
Article
Oncology
Menglu Zhang, Jiaqi Liu, Gang Liu, Zeyu Xing, Ziqi Jia, Jiaxin Li, Wenyan Wang, Jie Wang, Ling Qin, Xin Wang, Xiang Wang
Summary: Breast cancer, the highest incidence of female malignancy, is heavily reliant on neo-vascularization for growth and metastasis, with Vascular Endothelial Growth Factor (VEGF) playing a crucial role. This review focuses on the prognostic value of VEGF in breast cancer, clinical experiences with anti-VEGF therapeutics, and biomarkers for predicting the effectiveness of anti-angiogenic treatment.
Article
Cell Biology
Shiqi Yang, Tong Li, Huixun Jia, Min Gao, Yiming Li, Xiaoling Wan, Zhen Huang, Min Li, Yuanqi Zhai, Xiaomeng Li, Xiaotong Yang, Tao Wang, Jian Liang, Qing Gu, Xueting Luo, Lei Qian, Shujie Lu, Junjian Liu, Yanping Song, Fenghua Wang, Xiaodong Sun, Dechao Yu
Summary: Antiangiogenesis therapies targeting VEGF have revolutionized the treatment of neovascular ocular diseases. This study reports the preclinical assessment and phase 1 clinical outcomes of a bispecific fusion protein, efdamrofusp alfa, which showed superior efficacy over anti-VEGF monotherapy in a mouse model. These findings suggest that efdamrofusp alfa may be effective for treating neovascular ocular diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hui Lu, Tao Yue, Na Liu, Zuo-Fen Wang, Gai-Xia Zhai, Dong-Ming Mi, Jing Zhang, Shao-Peng Wang
Summary: Conbercept intravitreal injection significantly reduces central retinal thickness and choroidal neovascularization area, inhibits CNV leakage, improves BCVA, and enhances mfERG amplitude response, showing to be safe and effective for pathologic myopia CNV treatment.
FRONTIERS IN MEDICINE
(2021)