Article
Ophthalmology
Adi Porat Rein, Adi Abulafia, David Zadok, Joel Hanhart, Evgeny Gelman, Yishay Weill
Summary: The study evaluated the additive value of foveal swept-source OCT-based biometry for diagnosing macular abnormalities in patients scheduled for cataract surgery. The combination of fundus biomicroscopy and foveal swept-source OCT scans showed improved sensitivity and specificity in detecting macular abnormalities compared to fundus biomicroscopy alone, but was inferior to macular spectral-domain OCT scans. Further studies are needed to assess the cost-effectiveness of adding foveal swept-source OCT scan in comparison to macular spectral-domain OCT scan for preoperative cataract evaluation.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Lei Shao, Ling Xiao Zhou, Liang Xu, Wen Bin Wei
Summary: The Beijing Eye Study 2011 found that in cases of hypertension, patients with hypertensive retinopathy had significantly thicker subfoveal choroidal thickness, which was significantly associated with the stage of hypertensive retinopathy. However, subfoveal choroidal thickness was not significantly associated with diastolic blood pressure, history of hypertension, or years of hypertension.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Minjie Chen, Anji Wei, Jianjiang Xu, Xingtao Zhou, Jiaxu Hong
Summary: This study compares the interoperator repeatability and agreement between tear meniscus height (TMH) measurements obtained with a keratograph and Fourier-domain optical coherence tomography (FD-OCT) and evaluates their efficacy in detecting dry eye disease (DED). The results reveal that the TMHs measured with the keratograph are slightly lower than those obtained with FD-OCT. FD-OCT TMH measurements are more reliable than keratograph data in the DED group, although there is poor agreement between the two devices in both groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Optics
Jianan Fang, Kun Huang, E. Wu, Ming Yan, Heping Zeng
Summary: This article introduces an infrared 3D imaging system capable of detecting three-dimensional structure and reflectivity information. The system operates at single-photon sensitivity and femtosecond timing resolution, enabling imaging under low-light conditions. By nonlinear frequency upconversion and recording with a silicon camera, the presented system achieves high lateral and depth resolutions for 3D reconstruction. Additionally, a numerical denoiser based on spatiotemporal correlation allows the retrieval of object profile and reflectivity even with a detected flux below 0.05 photons/pixel/second. This infrared 3D imager features high detection sensitivity, precise timing resolution, and wide-field operation, offering new possibilities in life and material sciences.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Multidisciplinary Sciences
Jiayun Wang, Sabine Baumgarten, Frederic Balcewicz, Sandra Johnen, Peter Walter, Tibor Lohmann
Summary: This study establishes a workflow to visualize the surgical anatomy of eyes in 3D based on histological data from experimental animals. The resulting models can be used to improve the planning of complex surgical procedures and aid in the design of intraocular implants. The study highlights the importance of 3D visualization in surgical teaching and its potential to reduce the number of experimental animals used.
Article
Optics
Zunyue Zhang, Yi Wang, Jiarui Wang, Dan Yi, David Weng U. Chan, Wu Yuan, Hon Ki Tsang
Summary: In this study, a compact integrated scanning spectrometer is proposed, which utilizes a tunable micro-ring resonator and a single arrayed waveguide grating to achieve wide optical bandwidths and high spectral resolutions. The integrated spectrometer with germanium photodetectors demonstrates excellent performance.
PHOTONICS RESEARCH
(2022)
Article
Biology
Elvira Orduna-Hospital, Maria Munarriz-Escribano, Ana Sanchez-Cano
Summary: This study objectively evaluated visual discomfort after a 21-min reading session on an iPad and an Ebook using an eye tracker and aberrometer. The results showed no significant differences in eye movements and retinal thickness between the two devices, but variations were observed in post-reading situations depending on the device used.
Article
Optics
Daewoon Seong, Won Ki, Pilun Kim, Jaeyul Lee, Sangyeob Han, Soojin Yi, Hong Kyun Kim, Mansik Jeon, Jeehyun Kim
Summary: This study developed a virtual intraoperative OCT angiography integrated surgical microscope, which can simultaneously visualize the morphological tissue structure and microvasculature data of the surgical region, demonstrating its potential application in in vivo imaging and simulated surgeries of small animals.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Min-Su Kim, Ki-Yup Nam, Young Hoon Hwang, Min-Woo Lee, Woo-Hyuk Lee, Hyung-Bin Lim, Jung-Yeul Kim
Summary: It was found that Weiss ring located near the optic disc can affect the measurement of peripapillary retinal nerve fiber layer (pRNFL) thickness, especially in the inferior quadrant and average values. Therefore, it is important to consider the presence of Weiss ring when analyzing pRNFL thickness.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kaveri A. Thakoor, Jiaang Yao, Darius Bordbar, Omar Moussa, Weijie Lin, Paul Sajda, Royce W. S. Chen
Summary: This study describes a deep learning approach using multimodal data to detect age-related macular degeneration (AMD) and its biomarkers. By applying Convolutional Neural Networks (CNNs), the accuracy of biomarker prediction reached up to 90.2% (with a positive predictive value of up to 75.8%), offering the potential to expedite screening of early and late-stage AMD patients.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Guangying Ma, Taeyoon Son, Tobiloba Adejumo, Xincheng Yao
Summary: Accurate image registration is crucial for eye movement compensation in OCT and OCTA. This study quantitatively analyzed residual distortion and false translation under different rotational degrees and lateral/axial pixel resolution ratios. Theoretical analysis confirmed that residual distortion and false translation increase significantly with rotation degree and pixel resolution ratio. A resizing-assisted registration strategy was proposed to improve the performance of image registration and distortion compensation.
BIOENGINEERING-BASEL
(2023)
Article
Orthopedics
M. Goodwin, M. Klufts, J. Workman, A. Thambyah, F. Vanholsbeeck
Summary: This study explores the potential of polarization-sensitive optical coherence tomography (PS-OCT) to rapidly identify subtle signs of tissue degeneration in horse joints. The results show that PS-OCT can non-invasively detect sub-surface microstructural changes associated with early stages of joint tissue degeneration, which are not visible with dissection and microscopy.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Optics
Tanbin Shao, Kecheng Yang, Min Xia, Wenping Guo
Summary: In this study, an enhanced dispersion-encoded full-range spectral interferometry technique is proposed and validated for improving measurement accuracy in samples with significant depth, inclination, and roughness. By removing the direct current and preserving data with good phase continuity, the accuracy of phase compensation is improved. The proposed technique extends the depth measurement range and achieves high axial measurement precision.
Article
Optics
Dong Yang, Zhongming Yang, Yanfeng Zhang
Summary: This paper proposes and demonstrates a nano-displacement measurement system based on WSI-OAM, which features compact size and easy alignment. It achieves high accuracy and linearity with a resolution of 0.1 nm and an uncertainty of 0.013 nm for measuring nanoscale displacements.
Article
Medicine, General & Internal
Thanh-Tin P. Nguyen, Shuibin Ni, Guangru Liang, Shanjida Khan, Xiang Wei, Alison Skalet, Susan Ostmo, Michael F. Chiang, Yali Jia, David Huang, Yifan Jian, J. Peter Campbell
Summary: OCT has changed the standard of care for macular diseases in adults, but commercially available systems have a narrow FOV limiting their application to peripheral pathologies; OCT-based evaluation can improve diagnosis of all types of retinal detachment.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jeffrey S. Heier, Arshad M. Khanani, Carlos Quezada Ruiz, Karen Basu, Philip J. Ferrone, Christopher Brittain, Marta S. Figueroa, Hugh Lin, Frank G. Holz, Vaibhavi Patel, Timothy Y. Y. Lai, David Silverman, Carl Regillo, Balakumar Swaminathan, Francesco Viola, Chui Ming Gemmy Cheung, Tien Y. Wong
Summary: The primary results of two Phase 3 trials show that faricimab can effectively improve visual acuity for patients with nAMD at intervals of up to 16 weeks, with comparable safety profile to aflibercept. This suggests that faricimab has the potential to reduce treatment burden by extending the time between injections while maintaining efficacy.
Article
Environmental Sciences
Magdalena Musial-Kopiejka, Katarzyna Polanowska, Dariusz Dobrowolski, Katarzyna Krysik, Edward Wylegala, Beniamin Oskar Grabarek, Anita Lyssek-Boron
Summary: This study compared the effectiveness of brolucizumab and aflibercept in treating neovascular AMD, and found that brolucizumab was more effective than aflibercept during a 20-week monitoring period.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Michal Dembski, Anna Nowinska, Klaudia Ulfik-Dembska, Edward Wylegala
Summary: This study used SS-OCT to investigate the characteristics of the iridocorneal angle and cornea in patients with PEX syndrome. The results showed that PEX syndrome significantly affected the anterior eye segment, including higher keratometric values, shallower anterior chamber depth, thicker iris, and narrower angle parameters. These characteristic features of PEX syndrome can be detected using SS-OCT, which can assist clinicians in managing the disease properly.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Magdalena Krok, Ewa Wroblewska-Czajka, Joanna Kokot, Anna Micinska, Edward Wylegala, Dariusz Dobrowolski
Summary: The objective of this paper is to analyze the occurrence of sterile infiltrate in patients with keratoconus after corneal collagen cross-linking (CXL) and evaluate possible risk factors. The study found that the occurrence of sterile infiltrates after CXL was relatively low, but damage to the epithelium and the phototoxic effect of the procedure were significant factors. Appropriate classification and selection of CXL procedures, along with protective measures, can have a significant impact on reducing the incidence of this complication.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Michal Jan Stasiowski, Aleksandra Pluta, Anita Lyssek-Boron, Seweryn Krol, Lech Krawczyk, Ewa Niewiadomska, Jakub Zak, Magdalena Kawka, Dariusz Dobrowolski, Beniamin Oskar Grabarek, Izabela Szumera, Michael Janusz Koss, Anna Missir, Robert Rejdak, Przemyslaw Jalowiecki
Summary: This study evaluated the risk factors for PONV and OCR in patients undergoing vitreoretinal surgeries guided by AoA. Obesity, overweight, smoking, motion sickness, postoperative pain perception, female gender, fluid challenge, and arterial hypertension were found to not correlate with an increased incidence of PONV or OCR. However, diabetes mellitus was found to be a risk factor for PONV.
Article
Medicine, General & Internal
Giuseppe Acri, Antonio Micali, Rosalia D'Angelo, Domenico Puzzolo, Pasquale Aragona, Barbara Testagrossa, Emanuela Aragona, Edward Wylegala, Anna Nowinska
Summary: This study examined the genetic and histopathological features of a Polish patient with GDCD, as well as the molecular composition of corneal deposits using Raman spectroscopy. A novel homozygous deletion mutation in the TACSTD2 gene was identified in the patient. The study also found distinct differences in Raman spectra between normal and GDCD corneas.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Slawomir Jan Teper, Anna Nowinska, Malgorzata Figurska, Marek Rekas, Edward Wylegala
Summary: The Polish National AMD Therapeutic Program revealed that the proportion of the elderly population (65 years and older) requiring nAMD treatment is estimated to be around 0.55-0.66%. The COVID-19 pandemic has resulted in a decrease in the number of enrollments in the therapeutic program, highlighting the necessity for increased vigilance.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Medicine, General & Internal
Michal Orski, Rafal Tarnawski, Edward Wylegala, Dorota Tarnawska
Summary: This study evaluated the radiation effect of fractionated robotic radiotherapy on benign tumors located in the parasellar region. The results showed that this treatment is safe and does not impair patient's vision. Minor changes in optic nerve anatomy and a slight decrease in endothelial cell density were observed, but they did not cause noticeable visual disturbances.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Adam Wylegala, Anna M. Roszkowska, Joanna Kokot, Dariusz Dobrowolski, Edward Wylegala
Summary: This study aimed to evaluate the clinical outcome, efficacy, and safety of femtosecond laser-assisted anterior lamellar keratoplasty. The results showed a significant improvement in visual acuity postoperatively, indicating the safety and effectiveness of this surgical method with a high graft survival rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Robert Mazur, Adam Wylegala, Edward Wylegala, Dariusz Dobrowolski
Summary: This study compared the keratometry, astigmatism, and astigmatism axes of the posterior surface of the cornea, as well as the total, central cornea thickness and thinnest corneal thickness measured using two different measurement methods. The results showed that the measurements obtained using Casia2 and the Dual Scheimpflug Analyzer GalileiG6 were significantly different and not interchangeable except for total Ks and Kf.
Article
Biology
Michal Jan Stasiowski, Aleksandra Pluta, Anita Lyssek-Boron, Ewa Niewiadomska, Lech Krawczyk, Dariusz Dobrowolski, Beniamin Oskar Grabarek, Magdalena Kawka, Robert Rejdak, Izabela Szumera, Anna Missir, Przemyslaw Holys, Przemyslaw Jalowiecki
Summary: Vitreoretinal surgery is a common ophthalmic procedure that is usually performed under regional anesthesia. However, in some situations, general anesthesia is needed. This study examined the effect of using a surgical pleth index-based titration of fentanyl along with various pre-emptive analgesia techniques on intraoperative pain perception during vitreoretinal surgery. The results showed that none of the techniques used were superior to general anesthesia with fentanyl dosing in providing efficient analgesia throughout the surgery.
Article
Ophthalmology
Monica Alves, Penny Asbell, Murat Dogru, Giuseppe Giannaccare, Arturo Grau, Darren Gregory, Dong Hyun Kim, Maria Cecilia Marini, William Ngo, Anna Nowinska, Ian J. Saldanha, Edoardo Villani, Tais Hitomi Wakamatsu, Mitasha Yu, Fiona Stapleton
Summary: This article reviews the environmental risk factors that impact the ocular surface, including climate-related factors (temperature, humidity, wind speed, altitude, dew point, ultraviolet light, and allergens) and outdoor/indoor pollution. These factors are associated with various ocular surface diseases and symptoms. Dry eye disease is associated with air and soil pollution, but not with air pollution from CO or PM10. Future research should consider confounders, long-term follow-ups, and separate reporting of ocular surface findings.
Meeting Abstract
Ophthalmology
Anna Nowinska, Slawomir Teper, Edward Wylegala
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Anna Nowinska, Dariusz Dobrowolski, Ewa Wroblewska-Czajka, Ula Jurkunas, Edward Wylegala
Summary: This study evaluated the long-term outcomes of Boston type 1 keratoprosthesis (BKPro) surgery in 6 Polish patients. The indications for surgery included corneal graft failure, chemical ocular burns, and post-herpetic keratitis vascularized leucoma. The results showed successful retention of the keratoprosthesis in all patients, with complications including glaucoma, membrane formation, and Meibomian Gland Dysfunction. Optical coherence tomography (OCT) was found to be useful in monitoring the anterior eye segment and detecting complications not visible on slit lamp examination. Implementing dry eye disease treatment was recommended for all patients undergoing BKPro surgery.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Klaudia Ulfik-Dembska, Slawomir Teper, Michal Dembski, Anna Nowinska, Edward Wylegala
Summary: This study found that idiopathic ERM patients had a smaller foveal avascular zone, higher retinal thickness, and thicker fovea. The changes in the superficial plexus were related to the severity of metamorphopsia.