Article
Biochemistry & Molecular Biology
Jufen Liu, Huijing Wang, Cuiting Huang
Summary: This study found that Exendin-4 has a protective effect in inhibiting the progression of DR, and it may exert its effect by regulating the expression of TGFB2.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Amaara Marzook, Shiqian Chen, Phil Pickford, Maria Lucey, Yifan Wang, Ivan R. Jr Jr Correa, Johannes Broichhagen, David J. Hodson, Victoria Salem, Guy A. Rutter, Tricia M. Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Summary: In this study, differences between the GLP-1R agonists P5 and exendin-F1 were examined through various assays, revealing that while exendin-F1 showed lower acute efficacy, it demonstrated greater effects on insulin secretion and sustained anti-hyperglycaemic efficacy in mice compared to P5.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shujuan Xu, Fang Wang, Hui Li, Ya Wang, Dongzhong Fang
Summary: This study designed a long-lasting Exendin-4 analog (HEX15) for treating type 2 diabetes and its complications via albumin binding and thrombin enzymolysis. HEX15 showed enhanced albumin-binding affinity, controlled-release, and stability, resulting in improved glucose tolerance and prolonged normoglycemic duration in diabetic mice. Chronic dosing of HEX15 also improved manifestations of diabetes in db/db mice and accelerated wound healing in model rats with diabetic foot ulcers when combined with long non-coding RNA-ENST00000411554.
Review
Biochemistry & Molecular Biology
Alessandra Puddu, Davide Maggi
Summary: This review discusses the anti-inflammatory effects of GLP-1R activation in the retina. GLP-1 has important roles in glucose and weight regulation, and is beneficial in the treatment of type 2 diabetes. Furthermore, GLP-1R activation has anti-inflammatory effects and may have potential therapeutic value in inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yoshiaki Shimada, Masayuki Shibuya, Kei Shinoda
Summary: This study observed changes in mfERGs before and after retinal photocoagulation, finding that the amplitude in the irradiated area transiently increased post-treatment and then significantly decreased, indicating dynamic alterations in retinal function following the procedure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Zhuanzhuan Wang, Xin Cui, Wenhui Yan, Na Liu, Jia Shang, Xinyao Yi, Tingli Guo, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Weina Ma, Wei Cui, Lina Chen
Summary: This study aims to investigate whether small molecule GLP-1R agonists from traditional Chinese medicine can improve diabetic cognitive dysfunction. The findings suggest that mollugin can improve cognitive dysfunction in T2DM mice through activating the GLP-1R/cAMP/PKA signaling pathway.
Article
Biochemistry & Molecular Biology
Khaoula Errafii, Olfa Khalifa, Neyla S. Al-Akl, Abdelilah Arredouani
Summary: No therapy exists for non-alcoholic fatty liver disease (NAFLD). However, glucagon-like peptide receptor agonists (GLP-1RAs) showed a beneficial effect on NAFLD. The study examined the signaling pathways involved in the protective effect of the GLP-1RA Exendin-4 (Ex-4) using comparative transcriptomics in a cell model of steatosis. It identified several key pathways, including FXR/RXR and LXR/RXR, that may contribute to the protective effect of GLP-1RAs on NAFLD.
Article
Medicine, Research & Experimental
Khaoula Errafii, Neyla S. Al-Akl, Olfa Khalifa, Abdelilah Arredouani
Summary: This study confirmed that Ex-4 can improve steatosis in HepG2 cells and identified 379 and 180 differentially expressed LncRNAs between untreated, steatotic, and Ex-4-treated steatotic cells. Functional enrichment analysis revealed critical pathways involved in fatty acid and pyruvate metabolism, insulin, PPAR, Wnt, TGF-beta, mTOR, VEGF, NOD-like, and Toll-like receptors signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Edwiges de Fatima de Oliveira, Alodia Brasil, Anderson Manoel Herculano, Matheus A. Rosa, Bruno Duarte Gomes, Fernando Allan de Farias Rocha
Summary: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia, which can lead to microvascular damage in the retina causing diabetic retinopathy. This study aimed to evaluate the potential protective effect of acai on retinal function in mice with induced diabetes. The results showed that treatment with acai prevented a significant decrease in visual electrophysiological responses in diabetic animals.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Kentaro Sakaki, Takaaki Murakami, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Daisuke Otani, Sakura Kiyobayashi, Takuya Okada, Masakazu Fujimoto, Takuro Hakata, Ichiro Yamauchi, Kotaro Shimada, Hironori Shimizu, Kazuyuki Nagai, Yuji Nakamoto, Nobuya Inagaki
Summary: F-18-exendin-4 PET/CT is a noninvasive diagnostic technique that can help localize insulinomas, and it is crucial for curative surgical resection.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Olfa Khalifa, Khalid Ouararhni, Khaoula Errafii, Nehad M. Alajez, Abdelilah Arredouani
Summary: The study found that the GLP-1RA exendin-4 (Ex-4) can reverse the expression of a set of miRNAs, reducing the occurrence of fatty liver. Enrichment pathway analysis showed that the differentially expressed miRNAs were associated with hepatic fibrosis, insulin receptor, PPAR, Wnt/beta-Catenin, VEGF, mTOR receptor signaling pathways, fibrosis of the liver, cirrhosis of the liver, proliferation of hepatic stellate cells, diabetes mellitus, glucose metabolism disorder, and proliferation of liver cells. These findings suggest that miRNAs may play an important role in the process of reducing fatty liver in response to GLP-1R agonists, which warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Huan-ran Zhou, Xue-fei Ma, Wen-jian Lin, Ming Hao, Xin-yang Yu, Hong-xue Li, Cheng-ye Xu, Hong-yu Kuang
Summary: In high glucose conditions, GLP-1 analog can alleviate damage to retinal ganglion cells (RGCs) and prevent mitophagy, demonstrating a neuroprotective effect. This provides new insights for preventing diabetic retinopathy (DR) by expanding the multi-organ benefits of GLP-1 analogs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaowen Deng, Zijing Li, Peng Zeng, Jing Wang, Jiaqi Liang, Yuqing Lan
Summary: The study constructed a proper model for screening diabetic retinopathy (DR) using RETeval. By combining the DR risk assessment protocol with the decision tree model, it improved the sensitivity of diagnosing DR, making it more suitable for DR screening than the current protocol.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Shimpei Iikuni, Ichiro Kamei, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono
Summary: A GLP-1R imaging probe [In-111]In-E4DA1 has been developed, which can detect the location of insulinomas in vivo and has reduced renal accumulation.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, General & Internal
Dandan Mao, Huanyi Cao, Mai Shi, Chi Chiu Wang, Joseph Kwong, Joshua Jing Xi Li, Yong Hou, Xing Ming, Heung Man Lee, Xiao Yu Tian, Chun Kwok Wong, Elaine Chow, Alice Pik Shan Kong, Vivian Wai Yan Lui, Paul Kay Sheung Chan, Juliana Chung Ngor Chan
Summary: Our study revealed that the expression of PSMA2 and GLP-1R was increased and positively correlated in T2D-related cervical cancer specimens, suggesting hyperglycemia might promote cancer growth by increasing PSMA2 expression, which could be attenuated by Exendin-4.