期刊
GLYCOCONJUGATE JOURNAL
卷 30, 期 8, 页码 759-768出版社
SPRINGER
DOI: 10.1007/s10719-013-9479-5
关键词
Gastric ulcer; Mushroom; NSAIDs; Polysaccharide; Termitomyces eurhizus
资金
- Board of Research in Nuclear Science (BRNS), Department of Atomic Energy (DAE), GOI India
- BRNS, DAE, GOI
The current study aims to determine the healing activity of water soluble polysaccharide-rich fraction of a wild mushroom, Termitomyces eurhizus (TEps) against the indomethacin induced gastric ulceration in mice model. Gastric tissue histology, myeloperoxidase (MPO) activity, cyclooxygenases (COX) 1 and 2 expression, prostaglandin E-2 (PGE(2)) synthesis, and modulation of pro/anti inflammatory cytokines expression were studied for this purpose. Histological study shows that TEps (20 mg/kg) effectively healed the gastric ulceration. Based on biochemical results, the healing capacities of TEps could be attributed to reduction of MPO activity and protection of mucosal mucin content. Enhanced synthesis of PGE(2) by modulation of COX-1 and COX-2 expression and a prominent shift of cytokines expression from pro (TNF-alpha, IL-1) to anti inflammatory (IL-10) side are also held responsible for ulcer healing. The preliminary study highlights the anti-ulcerogenic property of polysaccharide-rich fraction of Termitomyces eurhizus and opens an alternative cure for NSAID induced gastroduodenal diseases.
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