Galectins and their ligands: negative regulators of anti-tumor immunity

Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

(2014) S. R. Stowell et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 Expression

(2012) F. Cedeno-Laurent et al.   JOURNAL OF IMMUNOLOGY

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress

(2011) Koichi Ito et al.   ANGIOGENESIS

Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders

(2011) J. Ouyang et al.   BLOOD

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

Galectin-3 – A jack-of-all-trades in cancer

(2011) Anna U. Newlaczyl et al.   CANCER LETTERS

Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis

(2011) A. Banh et al.   CANCER RESEARCH

Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity

(2011) Gordana Radosavljevic et al.   CLINICAL & EXPERIMENTAL METASTASIS

Galectin-1 research in T cell immunity: Past, present and future

(2011) Filiberto Cedeno-Laurent et al.   CLINICAL IMMUNOLOGY

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

(2011) Shigeru Tsuboi et al.   EMBO JOURNAL

Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire ofN- andO-Glycans without Direct Incorporation

(2011) Steven R. Barthel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor Immunity

(2011) Filiberto Cedeno-Laurent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

(2010) Kimberley A. Stannard et al.   CANCER LETTERS

A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice

(2010) N. Demotte et al.   CANCER RESEARCH

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

(2010) J. Wei et al.   CLINICAL CANCER RESEARCH

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Galectin-3 mediates post-ischemic tissue remodeling

(2009) Yi-Ping Yan et al.   BRAIN RESEARCH

The costimulatory role of TIM molecules

(2009) Roselynn Rodriguez-Manzanet et al.   IMMUNOLOGICAL REVIEWS

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

The immunological potential of galectin-1 and -3

(2008) Amy Dhirapong et al.   AUTOIMMUNITY REVIEWS

Synthesis of stable and selective inhibitors of human galectins-1 and -3

(2008) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Tumor-Associated Galectin-3 Modulates the Function of Tumor-Reactive T Cells

(2008) W. Peng et al.   CANCER RESEARCH

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

(2008) Masako Seki et al.   CLINICAL IMMUNOLOGY

Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function

(2008) Claudia C. Motran et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of CD7, independent of galectin-3 expression, implies a worse prognosis in adult T-cell leukaemia/lymphoma

(2008) Ting-Yun Liu et al.   HISTOPATHOLOGY

Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways

(2008) Shuguang Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Galectin-1 and Galectin-3 Levels in Benign and Malignant Nodular Thyroid Disease

(2008) Sven Saussez et al.   THYROID