期刊
GLIA
卷 61, 期 12, 页码 2000-2008出版社
WILEY-BLACKWELL
DOI: 10.1002/glia.22571
关键词
BrdU; immune cells; Trigeminal nerve; trigeminal ganglion; neuropathic pain; nerve injury
资金
- NIH [NS061241, NS051336]
- Painless Research Foundation
We have examined satellite glial cell (SGC) proliferation in trigeminal ganglia following chronic constriction injury of the infraorbital nerve. Using BrdU labeling combined with immunohistochemistry for SGC specific proteins we positively confirmed proliferating cells to be SGCs. Proliferation peaks at approximately 4 days after injury and dividing SGCs are preferentially located around neurons that are immunopositive for ATF-3, a marker of nerve injury. After nerve injury there is an increase GFAP expression in SGCs associated with both ATF-3 immunopositive and immunonegative neurons throughout the ganglia. SGCs also express the non-glial proteins, CD45 and CD163, which label resident macrophages and circulating leukocytes, respectively. In addition to SGCs, we found some Schwann cells, endothelial cells, resident macrophages, and circulating leukocytes were BrdU immunopositive.
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