期刊
GLIA
卷 58, 期 14, 页码 1748-1756出版社
WILEY
DOI: 10.1002/glia.21045
关键词
reactive astrocytes; VLA-1; axon growth inhibition; Sema7A
资金
- German Research Council (DFG, Research Training School, Neuroinflammation) [1258]
- Berlin-Brandenburg Center for Regenerative Therapies (BCRT) [81717034]
- International Foundation for Research in Paraplegia, Switzerland (IFP) [P102]
- Wings for Life Spinal Cord Research Foundation, Austria
Semaphorin 7A (Sema7A) is involved in the formation of the central nervous system during development by operating axon guidance and neuronal migration. We investigated the expression of the TGF beta-inducible Sema7A following spinal cord injury (SCI). After SCI, Sema7A(+) cells accumulated specifically in lesion areas resulting in significantly enhanced Sema7A expression at the injury site (P < 0.0001). During the first days lesional Sema7A expression was confined to neurons, ballooned neurite fibers/retraction bulbs, and endothelial cells. At day 7, we observed Sema7A expression by components of the glial scar, such as reactive astrocytes and pronounced extracellular Sema7A deposition. In the direct perilesional rim, Sema7A(+) astrocytes coexpressed the activation-associated intermediate filament vimentin. In the injured spinal cord, numbers of Sema7A(+) cells reached maximum levels at day 14. The restricted accumulation of Sema7A(+) reactive astrocytes and Sema7A deposition in fibronectin(+) extracellular matrix territories suggests a participation of the fibrostimulatory Sema7A in the developing and maturating scar following SCI. In addition, Sema7A appears to be marker a for astrocyte activation. (C) 2010 Wiley-Liss, Inc.
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