Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Pharmacology & Pharmacy
Jin-Tao Guan, Wei-Jie Wang, Du Jin, Xiao-Yue Mou, Shan-Shan Lei, Zheng-Hao Xu
Summary: This meta-analysis showed that GM-CSF antibody treatment in COVID-19 patients could reduce the risk of death and increase ventilation, without significantly increasing the risk of secondary infection or ICU admission. Older age and length of stay may have an impact on these outcomes.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Immunology
Peilin Chen, Chunyu Huang, Qing Sun, Huixian Zhong, Feng Xiong, Su Liu, Zhihong Yao, Zhiqiang Liu, Caiyun Wan, Yong Zeng, Lianghui Diao
Summary: This study investigated the concentration of GM-CSF in human single-blastocyst conditioned medium (SBCM) and its association with embryo quality and pregnancy outcome. GM-CSF was found to be a potential biomarker for predicting pregnancy outcome and selecting embryos with high developmental potential for transfer in assisted reproductive technology (ART).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Immunology
Yu-Pei Zhuang, Zhao-Yu Pan, Jian-Ming Huang, Hong-Guang Zhou, Xiao-Rong Yang, Hao-Jie Zhong
Summary: This study examined the characteristics of ILC3s in patients with type 2 diabetes (T2D) and found that the proportion of ILC3s was negatively correlated with disease severity. ILC3s may delay the progression of T2D by promoting DC differentiation via the secretion of GM-CSF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lin Zhou, Han Li, Xin-xue Zhang, Yang Zhao, Jing Wang, Li-chao Pan, Guo-sheng Du, Qiang He, Xian-liang Li
Summary: The study showed that tolDCs derived from Rapa-modified BM-MSCs improved tolerance characteristics of CD8+CD45RC-Treg in a rat acute liver transplantation model, leading to reduced rejection of grafts.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oleksii Skorokhod, Valentina Barrera, Giorgia Mandili, Federica Costanza, Elena Valente, Daniela Ulliers, Evelin Schwarzer
Summary: The study demonstrates that malarial pigment hemozoin has a functional impact on the GM-CSF receptor in monocytes and monocyte-derived dendritic cells, leading to defective dendritic cell differentiation in malaria.
Article
Oncology
Lan Huang, Guisi Chen, Ying Chen, Wanwen Wu, Changli Tao, Hongwei Shao, Shulin Huang, Han Shen
Summary: Tumor immunotherapy targeting tumor-associated antigens and the impact of GM-CSF and CCL17 on tumor immunity have been widely studied. Combining survivin-specific CTL with CCL17 and GM-CSF genes can inhibit tumor growth more effectively through stable cell lines expressing these genes.
Article
Immunology
Moussa Gouife, Ziqi Ban, Xinyuan Yue, Jianhu Jiang, Jiasong Xie
Summary: This study investigated the immunomodulatory and functional properties of the goldfish MCSF-2 gene, revealing its important role in cell proliferation, differentiation, and survival. Recombinant goldfish MCSF-2 protein was successfully expressed and shown to stimulate proliferation and differentiation of leukocytes. Furthermore, rgMCSF-2 was found to modulate the expression of pro-inflammatory cytokines and transcription factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rui Chen, Yujie Li, Yangyang Zhuang, Yiming Zhang, Hailong Wu, Tao Lin, Shixuan Chen
Summary: This study combines GM-CSF and 3D nanofiber scaffolds to promote tissue regeneration. Through subcutaneous implantation in humanized mice, it was found that GM-CSF could accelerate cell migration and cytokine release, and ultimately enhance tissue regeneration. Therefore, GM-CSF loaded 3D nanofiber scaffolds have potential applications in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Asuka Iwamoto, Hirotake Tsukamoto, Hideki Nakayama, Hiroyuki Oshiumi
Summary: The study reveals that Riplet plays a suppressive role in the antitumor immune response mediated by T cells. Riplet deficiency enhances the antitumor immune response by modulating Th1 and CTLs.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Clinical Neurology
Michael Gliem, Anne Kathrin Mausberg, John-Ih Lee, Ioannis Simiantonakis, Nico van Rooijen, Hans-Peter Hartung, Sebastian Jander
ANNALS OF NEUROLOGY
(2012)
Article
Immunology
Andreas Weber, Corinna Zimmermann, Anne K. Mausberg, Bernd C. Kieseier, Hans Peter Hartung, Harald H. Hofstetter
INTERNATIONAL IMMUNOPHARMACOLOGY
(2013)
Article
Immunology
Vsevolod Smolianov, Thomas Dehmel, Patrick Vollmar, Anne K. Mausberg, Bernd C. Kieseier, Bernhard Hemmer, Hans P. Hartung, Harald H. Hofstetter
JOURNAL OF NEUROINFLAMMATION
(2011)
Article
Immunology
Philipp Albrecht, Imane Bouchachia, Norbert Goebels, Nadine Henke, Harald H. Hofstetter, Andrea Issberner, Zsuzsa Kovacs, Jan Lewerenz, Dmitrij Lisak, Pamela Maher, Anne-Kathrin Mausberg, Kim Quasthoff, Corinna Zimmermann, Hans-Peter Hartung, Axel Methner
JOURNAL OF NEUROINFLAMMATION
(2012)
Article
Immunology
Anne K. Mausberg, Fabian Szepanowski, Francesca Odoardi, Alexander Fluegel, Christoph Kleinschnitz, Mark Stettner, Bernd C. Kieseier
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Biochemical Research Methods
Mark Stettner, Kathleen Wolffram, Anne K. Mausberg, Christian Wolf, Sebastian Heikaus, Angelika Derksen, Thomas Dehmel, Bernd C. Kieseier
JOURNAL OF NEUROSCIENCE METHODS
(2013)
Article
Clinical Neurology
Mark Stettner, Thomas Dehmel, Anne K. Mausberg, Angelika Koehne, Christine R. Rose, Bernd C. Kieseier
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2011)
Article
Clinical Neurology
Anne K. Mausberg, Mareike Dorok, Mark Stettner, Matthias Mueller, Hans Peter Hartung, Thomas Dehmel, Clemens Warnke, Gerd Meyer Zu Hoerste, Bernd C. Kieseier
Article
Clinical Neurology
Clemens Warnke, Anne K. Mausberg, Mark Stettner, Thomas Dehmel, Lina Nekrich, Gerd Meyer Zu Horste, Hans-Peter Hartung, Anna Fogdell-Hahn, Ortwin Adams, Bernd C. Kieseier
Article
Multidisciplinary Sciences
Gerd Meyer Zu Hoerste, Anne K. Mausberg, Johanna I. Mueller, Helmar C. Lehmann, Stefan Loeber, Peter Gmeiner, Hans-Peter Hartung, Olaf Stueve, Carsten Korth, Bernd C. Kieseier
Article
Multidisciplinary Sciences
Mark Stettner, Kathleen Wolffram, Anne K. Mausberg, Philipp Albrecht, Angelika Derksen, Axel Methner, Thomas Dehmel, Hans-Peter Hartung, Helmut Dietrich, Bernd C. Kieseier
Article
Multidisciplinary Sciences
Daniel Degrandi, Elisabeth Kravets, Carolin Konermann, Cornelia Beuter-Gunia, Verena Kluempers, Sarah Lahme, Eva Wischmann, Anne K. Mausberg, Sandra Beer-Hammer, Klaus Pfeffer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Multidisciplinary Sciences
Felix P. Lubitz, Daniel Degrandi, Klaus Pfeffer, Anne K. Mausberg
SCIENTIFIC WORLD JOURNAL
(2013)
Article
Clinical Neurology
Bernd C. Kieseier, Olaf Stueve, Thomas Dehmel, Norbert Goebels, Verena I. Leussink, Anne K. Mausberg, Marius Ringelstein, Bernd Turowski, Orhan Aktas, Gerald Antoch, Hans-Peter Hartung
Article
Cardiac & Cardiovascular Systems
Christina David, Tobias Ruck, Leoni Rolfes, Stine Mencl, Peter Kraft, Michael K. Schuhmann, Christina B. Schroeter, Robin Jansen, Friederike Langhauser, Anne K. Mausberg, Anke C. Fender, Sven G. Meuth, Christoph Kleinschnitz
Summary: Ischemic stroke is a thromboinflammatory disease with early and delayed inflammatory responses. NKG2D, expressed on natural killer and T cells, plays a critical role in stroke progression. Blocking NKG2D can alleviate stroke outcome and improve survival in animal models.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
Marija Adzic Bukvic, Danijela Laketa, Milorad Dragic, Irena Lavrnja, Nadezda Nedeljkovic
Summary: In neuroinflammatory states, functionally distinct eN/CD73 glycovariants appear, which may play a role in the development of the reactive astrocyte phenotype.
Correction
Neurosciences
L. Feng, H. Lo, Z. Hong, J. Zheng, Y. Yan, Z. Ye, X. Chen, X. Pan