Article
Biotechnology & Applied Microbiology
Jieyun Sun, Xintian Chen, Xueying Ji, Sen Meng, Wenwen Wang, Pengfei Wang, Jin Bai, Zhongwei Li, Youguo Chen
Summary: TRIM21 expression is decreased in ovarian cancer patients and is associated with shorter survival. It inhibits cancer progression by suppressing cell migration, invasion, and proliferation. Therefore, TRIM21 may serve as a promising biomarker and therapeutic target for ovarian cancer.
Article
Neurosciences
Yongchang Guan, Wenjin Yang, Feng Zhang, Liming Zhang, Liang Wang
Summary: Background: The involvement of certain circular RNAs (circRNAs) in the development of glioma has been revealed. This study validated the positive association of circRNA periostin (circPOSTN) with glioma cell growth and metastasis. The mechanism of circPOSTN in glioma tumorigenesis, specifically its interaction with miR-185-5p/KIF1B axis, was elucidated.
BRAIN RESEARCH BULLETIN
(2022)
Article
Medicine, Research & Experimental
Fengqi Zhou, Binbin Wang, Hong Wang, Lang Hu, Junxia Zhang, Tianfu Yu, Xiupeng Xu, Wei Tian, Chunsheng Zhao, Haifeng Zhu, Ning Liu
Summary: This study demonstrates that circMELK acts as an oncogene in GBM, regulating mesenchymal transition and GSC maintenance by sponging miR-593. EphB2 is involved in the circMELK/miR-593 axis induced GBM tumorigenesis. This finding suggests a potential novel therapeutic target for gliomas.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Chunhong Wang, Haiyang Su, Rui Cheng, Hongming Ji
Summary: The study demonstrated that high expression of SPAG5 in glioma patients is associated with poor prognosis. Knockdown of SPAG5 can inhibit proliferation, migration, and invasion of glioma cells, promote apoptosis, and is associated with the expression of CDH2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fang Zhou, Lingfeng Zeng, Xi Chen, Fan Zhou, Zhen Zhang, Yixiao Yuan, Heping Wang, Huayi Yao, Jintao Tian, Xujie Liu, Jinxi Zhao, Xiaobin Huang, Jun Pu, William C. Cho, Jianxiong Cao, Xiulin Jiang
Summary: Dual-specificity phosphatase 10 (DUSP10) plays a crucial role in inflammation, cytokine secretion, cell proliferation, survival, and apoptosis. However, its role in glioma is still unclear. This study found that DUSP10 expression was significantly higher in glioma tissues compared to normal brain tissues and was associated with adverse clinical outcomes. Moreover, DUSP10 expression correlated with DNA methylation levels, infiltration of immune cells, and involvement in various signaling pathways. Knockdown of DUSP10 inhibited glioma cell proliferation and migration. These findings suggest that DUSP10 may serve as a potential prognostic biomarker in glioma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mingtao Zhu, Kunrong Li, Jing Zhang
Summary: In this study, we investigated the level of SLC25A21-AS1 in gliomas and its association with survival and progression in patients. We found that SLC25A21-AS1 was significantly downregulated in glioma specimens and cell lines compared to non-cancerous ones, and this downregulation was associated with poor prognosis. We also identified miR-221-3p/miR-222-3p as the target miRNAs for SLC25A21-AS1 and showed that overexpression of SLC25A21-AS1 inhibited glioma cell growth, invasion, and migration.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Oncology
Wei Zhao, Qiu-feng Dong, Li-wen Li, Zhi-feng Yan, Jun-li Huo, Xiao-yan Chen, Xin Yang, Peng-qi Li, Zhou Fei, Hai-ning Zhen
Summary: The study demonstrates that YAPBD can inhibit the growth and migration of glioma cells by blocking the formation of the TEAD-YAP complex, inducing cell cycle arrest and apoptosis. Therefore, gene therapy targeting the TEAD-YAP complex may be a novel and promising approach for the treatment of malignant gliomas in humans.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haitao Wen, Zhenwei Li, Sirong Song, Lixia Xu, Xiaoguang Tong, Hua Yan
Summary: This study demonstrated that LBX2-AS1 is significantly increased and negatively correlated with prognosis in glioma. Silencing LBX2-AS1 inhibited the proliferation, migration, and invasion of glioma cells and increased apoptosis. LBX2-AS1 was found to regulate the Akt/GSK3 beta pathway, making it a potential new target for glioma therapy.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Cell Biology
Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng, Meixiang Sang, Wei Lv, Jing Qin, Lihua Liu
Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zengpei Li, Dajun Li, Tianbin Yang, Chen Yao
Summary: This study revealed that NAT10 mediated ac4C modification of FOXM1 mRNA promotes the malignant processes of LSCC cells, including enhanced proliferation, migration, and invasion abilities.
CANCER BIOLOGY & THERAPY
(2023)
Article
Medicine, Research & Experimental
Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He
Summary: The study investigates the pathogenesis and potential molecular markers of glioma by examining the differential expression of miRNA and mRNA. Several miRNAs and mRNAs were identified as having significant impact on glioma cell behavior, with miR-139-5p/GABRA1 axis suggested as a novel therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Xi Zhan, Changcheng Lei, Linzhu Yang
Summary: The study found that sevoflurane inhibited glioma cell progression by increasing the expression of miR-27b and decreasing the expression of VEGF, thus improving patient outcomes.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Summary: The study revealed that the enhanced cell adhesion ability of mMDSC in the GBM microenvironment is linked to tumor promotion, and targeting Integrin (31) and DPP-4 to interfere with mMDSC may be an effective way to alleviate immune suppression driven by myeloid cells in GBM.
Article
Neurosciences
Zhengtao Yu, Yan Liu, You Li, Jikun Zhang, Jun Peng, Jianwu Gong, Ying Xia, Lei Wang
Summary: This study found that miRNA-338-3p suppresses glioma cell proliferation and migration, and promotes apoptosis by inhibiting the expression of MYT1L gene. The miRNA-338-3p/MYT1L axis may play a critical role in glioma progression and could be a potential therapeutic target.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Xu Xu, Yunan Hou, Niya Long, Lishi Jiang, Zhangwei Yan, Yuan Xu, Ying Lv, Xin Xiang, Hua Yang, Jian Liu, Xiaolan Qi, Liangzhao Chu
Summary: This study found that the expression of TPPP3 is higher in glioma compared to normal brain tissue, and increases with the grade of glioma. Up-regulation of TPPP3 enhances migration, invasion, and proliferation abilities, while reducing apoptosis in glioblastoma cells. TPPP3 also affects the process of EMT by regulating the expression of Snail1 protein. Low TPPP3 expression is associated with better survival expectations in glioblastoma patients. This study provides new insights and directions for further research on the role of TPPP3 in glioblastoma.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Qing Lan, Aidong Wang, Yanwei Cheng, Akitaki Mukasa, Jiawei Ma, Lei Hong, Shuye Yu, Lili Sun, Qiang Huang, Benjamin Purow, Ming Li
Article
Oncology
Zhaohui Lu, Jiawei Ma, Bing Liu, Chungang Dai, Tao Xie, Xiaoyu Ma, Ming Li, Jun Dong, Qing Lan, Qiang Huang
Article
Oncology
Inan Olmez, Shawn Love, Aizhen Xiao, Laryssa Manigat, Peyton Randolph, Brian D. McKenna, Brian P. Neal, Salome Boroda, Ming Li, Breanna Brenneman, Roger Abounader, Desiree Floyd, Jeongwu Lee, Ichiro Nakano, Jakub Godlewski, Agnieszka Bronisz, Erik P. Sulman, Marty Mayo, Daniel Gioeli, Michael Weber, Thurl E. Harris, Benjamin Purow
Article
Oncology
Jia Ouyang, Hui Xu, Ming Li, Xingliang Dai, Fengqing Fu, Xueguang Zhang, Qing Lan
Article
Oncology
Ming Li, Aizhen Xiao, Desiree Floyd, Inan Olmez, Jeongwu Lee, Jakub Godlewski, Agnieszka Bronisz, Krishna P. L. Bhat, Erik P. Sulman, Ichiro Nakano, Benjamin Purow
Article
Biochemistry & Molecular Biology
Hui Xu, Lili Sun, Yanwen Zheng, Shuye Yu, Jia Ou-yang, Hui Han, Xingliang Dai, Xiaoting Yu, Ming Li, Qing Lan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Lili Sun, Shuye Yu, Hui Xu, Yanwen Zheng, Juntang Lin, Meiyan Wu, Jide Wang, Aidong Wang, Qing Lan, Frank Furnari, Webster Cavenee, Benjamin Purow, Ming Li
Article
Biochemistry & Molecular Biology
Shuye Yu, Xiaoting Yu, Lili Sun, Yanwen Zheng, Lili Chen, Hui Xu, Jing Jin, Qing Lan, Clark C. Chen, Ming Li
Article
Biochemistry & Molecular Biology
Lili Sun, Lili Chen, Hua Zhu, Yumo Li, Clark C. Chen, Ming Li
Summary: The FHL1 protein promotes tumor growth and invasion in glioblastoma by interacting with EGFR and SP1, affecting the signaling cascades in GBM cells.
Article
Cell Biology
Xiaoting Yu, Jing Jin, Yanwen Zheng, Hua Zhu, Hui Xu, Jun Ma, Qing Lan, Zhixiang Zhuang, Clark C. Chen, Ming Li
Summary: GBP5 is highly expressed in GBM and promotes cell proliferation, migration, and invasion, negatively correlating with patient prognosis. Targeting GBP5 impairs tumor growth and extends survival time in mice with GBM tumors. The Src/ERK1/2/MMP3 axis is crucial for GBP5-promoted GBM aggressiveness, suggesting GBP5 as a potential novel target for GBM intervention.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Jing Jin, Florina Grigore, Clark C. Chen, Ming Li
Summary: Glioblastoma multiforme (GBM) is a primary brain tumor with a high mortality rate, and the treatment is mainly palliative. GBM contains subsets of GBM stem cells (GSCs) which are potentially associated with tumor initiation and exhibit resistance to radiotherapy and chemotherapy. Targeting self-renewal signaling pathways in cancer stem cells may help reduce tumor recurrence.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jie Li, Megan M. Kaneda, Jun Ma, Ming Li, Ryan M. Shepard, Kunal Patel, Tomoyuki Koga, Aaron Sarver, Frank Furnari, Beibei Xu, Sanjay Dhawan, Jianfang Ning, Hua Zhu, Anhua Wu, Gan You, Tao Jiang, Andrew S. Venteicher, Jeremy N. Rich, Christopher K. Glass, Judith A. Varner, Clark C. Chen
Summary: Precision medicine in oncology is leveraging clinical observations to identify molecular features that define exceptional responses. In a study on glioblastoma, it was found that exceptional responders show decreased accumulation of microglia/macrophages in the tumor microenvironment. Inhibition of PI3K gamma disrupted signaling pathways involving IL11 secretion, enhancing the therapeutic effects in glioblastoma models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Jun Ma, Clark C. Chen, Ming Li
Summary: The interaction between glioblastoma and its microenvironment, particularly involving tumor-associated macrophages and microglia, plays a crucial role in tumor development and treatment outcomes. Understanding the changes and functions of these cells may lead to new therapeutic approaches and improved prognosis for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jianfang Ning, Noah Gavil, Shaoping Wu, Sathi Wijeyesinghe, Eyob Weyu, Jun Ma, Ming Li, Florina-Nicoleta Grigore, Sanjay Dhawan, Alexander G. J. Skorput, Shawn C. Musial, Clark C. Chen, David Masopust, Pamela C. Rosato
Summary: This study reveals the presence of virus-specific memory T cells expressing tissue-resident markers in the immune microenvironment of glioblastoma. Reactivation of these cells through intratumoral delivery of virus-derived peptides leads to local immune activation and antineoplastic effects.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hui Xu, Jing Jin, Ying Chen, Guoqing Wu, Hua Zhu, Qing Wang, Ji Wang, Shenggang Li, Florina-Nicoleta Grigore, Jun Ma, Clark C. Chen, Qing Lan, Ming Li
Summary: This study reveals that the expression of interferon inducible guanylate binding protein 3 (GBP3) and stimulator of interferon genes (STING) is upregulated by Temozolomide (TMZ) treatment, contributing to TMZ resistance in glioblastoma. GBP3 physically interacts with STING and stabilizes its protein levels, leading to the expression of genes associated with resistance. Targeting GBP3 could enhance the sensitivity of glioblastoma to TMZ treatment. Clinically, high expression of GBP3 is correlated with poor outcomes in glioblastoma patients.