Article
Environmental Sciences
Ines Leitao, Miguel Pedro Mourato, Luisa Carvalho, Maria Conceicao Oliveira, Maria Matilde Marques, Luisa Louro Martins
Summary: Carbamazepine, a commonly used anti-epileptic drug, has been found in wastewater and can be absorbed by plants like lettuce, leading to oxidative stress in the plants. The study showed that CBZ induced oxidative stress in lettuce plants, with increased levels of hydrogen peroxide and malondialdehyde. Antioxidative enzymes like SOD, CAT, GPOD, APX played important roles in leaves, while CAT, GPOD, and GR showed increased activity in roots.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Divya Choudhary, Valentine Lagage, Kevin R. Foster, Stephan Uphoff
Summary: Genetically identical bacterial cells often exhibit different phenotypes, which is commonly explained as a bet-hedging strategy against unpredictable environmental threats. However, this study reveals that phenotypic heterogeneity in Escherichia coli's stress response to hydrogen peroxide stress has a fundamentally different basis. Through microfluidic experiments, it is found that the heterogeneity arises from precise and rapid feedback between individual cells and their immediate environment. Furthermore, cell-cell interactions play a crucial role in shielding each other from hydrogen peroxide, resulting in a collective phenotype that protects a significant portion of the population.
Article
Physics, Applied
Xu Lu, Sen Wang, Renwu Zhou, Zhi Fang, P. J. Cullen
Summary: Plasma bubbles are an efficient way to generate reactive species through plasma discharges and liquids. This study investigates discharge modes, characteristics, and plasma-liquid interactions in different electrode configurations. Direct contact between the discharge and solution in the bare electrode design greatly enhances physio-chemical reactions.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Plant Sciences
Tian-liang Chang, Qian-qian Xi, Xiang-yu Wei, Li Xu, Qian-qian Wang, Jia-yi Fu, Chen Ling, Yue Zuo, Yi Zhao, Hong-yan He, Yu-wei Zhao
Summary: Melatonin can help plants maintain stable redox homeostasis under cold stress, which has a positive impact on plant stress resistance.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Immunology
Zheng Gong, Qing Li, Jiayuan Shi, Guangwen Ren
Summary: Intracellular cytokine staining (ICS) is commonly used to determine the activation status of immune cells, but the presence of neutrophils can lead to overactivation and death of T cells, potentially misleading immunological research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sarah Palko, Nicholas J. Saba, Elias Mullane, Benjamin D. Nicholas, Yosuke Nagasaka, Jayakrishna Ambati, Bradley D. Gelfand, Akihito Ishigami, Paola Bargagna-Mohan, Royce Mohan
Summary: Muller glia (MG) have been found to play a crucial role in reactive gliosis and are associated with retinal degenerative diseases. This study shows that MG citrullination is broadly conserved in various models and human tissues. The enzyme PAD4 is responsible for the citrullination, and endfeet are identified as a location where citrullination initiates and sustains in retinal degeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Materials Science, Biomaterials
Yun Yu, Bo-Ru Xie, Xin-Hua Liu, Jing-Jie Ye, Han Cheng, Zhenlin Zhong, Xian-Zheng Zhang
Summary: In this study, nanoparticles composed of polymers containing oxalate ester and Pluronic F-127 were used to achieve accurate tumor imaging and treatment through H2O2-responsive chemiluminescence in the tumor microenvironment. Moreover, the nanoplatform activated the immune system for anti-metastatic activity.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Analytical
Ji Sun Park, Sun-Ki Kim, Chang-Hyung Choi, Jong Pil Park, Kyeongsoon Park
Summary: The overproduction of hydrogen peroxide (H2O2) is closely associated with the progression of various diseases, making it an important diagnostic marker for in vivo molecular imaging. A novel Co2+-doped L012/magnesium peroxide-based chemiluminescence (CL) nanosystem (L-012/Co@MgO2) has been developed for visual detection and quantitative analysis of H2O2, which has potential applications in biosensing and bioimaging of H2O2.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biochemistry & Molecular Biology
Youn Hye Jo, Go Woon Choi, Mi-Lyang Kim, Kyung Rim Sung
Summary: We characterized the gliosis induced by TRPV4 activation in Muller cells and assessed the modulatory effect of statins. The results showed that statins effectively inhibited Muller cell gliosis and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Claire Hippert, Anna B. Graca, Mark Basche, Aikaterini A. Kalargyrou, Anastasios Georgiadis, Joana Ribeiro, Ayako Matsuyama, Nozie Aghaizu, James W. Bainbridge, Alexander J. Smith, Robin R. Ali, Rachael A. Pearson
Summary: Gliosis is a complex process involving upregulation of IF proteins, changes in glial morphology, and increased deposition of inhibitory ECM molecules. Through RNAi approaches, it was found that GFAP and vimentin play crucial roles in the establishment of glial hypertrophy during disease progression. Suppression of both proteins led to severe changes in the retina's cytoarchitecture, suggesting potential therapeutic implications for modulating scar formation.
Review
Chemistry, Analytical
Ricardo Matias Trujillo, Daniela Estefania Barraza, Martin Lucas Zamora, Anna Cattani-Scholz, Rossana Elena Madrid
Summary: In recent years, nanomaterials have been widely used in optimizing electrochemical sensors for H2O2 sensing, with electrodes made of metal nanoparticles combined with organic and inorganic molecules to enhance sensing capabilities. The review article provides an overview of different nanomaterials, molecules, polymers, and transduction methods used in these devices, comparing their performance based on sensitivity values, limit of detection, and linear range of application reported in the literature.
Article
Biochemistry & Molecular Biology
Marina Alorda-Clara, Margalida Torrens-Mas, Pere Miquel Morla-Barcelo, Pilar Roca, Jorge Sastre-Serra, Daniel Gabriel Pons, Jordi Oliver
Summary: Genistein may increase oxidative stress and inflammation in colon cancer cells, ultimately decreasing cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Jiyu Zou, Yuhan Wang, Zhiming Zhang, Liping Shao, Shuwei Liang, Fusheng Pan, Zhongyi Jiang
Summary: Hydrogen peroxide, a green oxidant, has broad and increasing applications. Membrane technology offers a promising solution for in-situ production and concentration of hydrogen peroxide. Graphene oxide membranes show superior separation performance and antioxidative ability compared to conventional water-permeable membranes.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Cell & Tissue Engineering
Meryem B. Baghdadi, Arshad Ayyaz, Sabrina Coquenlorge, Bonnie Chu, Sandeep Kumar, Catherine Streutker, Jeffrey L. Wrana, Tae-Hee Kim
Summary: This study investigates the heterogeneity and regulation of enteric glial cells (EGCs) in the intestine during homeostasis and chronic inflammatory bowel disease. A specific subset of glial cells, expressing GFAP, is found to regulate the repair potential of intestinal stem cells (ISCs) through the expression of WNT ligands. The dynamically regulated heterogeneity of EGCs is revealed to be a key part of the intestinal stem cell niche in regeneration and disease.
Article
Biotechnology & Applied Microbiology
Feng Liu, Rui Min, Jie Hong, Guangqin Cheng, Yongqian Zhang, Yulin Deng
Summary: The study investigated the impact of endogenous oxidative stress caused by submicromolar hydrogen peroxide in a mutant strain of E. coli. Through label-free quantitative proteomic analysis, 265 differentially expressed proteins were identified, activating DNA repair and cellular antioxidant signaling pathways. These findings highlight the role of oxidative signaling and the potential of mutant E. coli as a cell model for studying oxidative stress effects.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)