Article
Biochemistry & Molecular Biology
Anshuly Tiwari, Siddharth J. Modi, Satish Y. Gabhe, Vithal M. Kulkarni
Summary: The study found that piperine is active against CD44+/CD133+ CSCs and suitable for respite at certain stages of the cell cycle. Additionally, piperine can repress the epithelial marker (E-cadherin) but cannot restore the level of Vimentin (mesenchymal marker) and SNAIL (EMT-inducing transcription factor).
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Priyanka Mohapatra, Swati Madhulika, Somalisa Behera, Priya Singh, Pratikshya Sa, Punit Prasad, Rajeeb Kumar Swain, Sanjeeb Kumar Sahoo
Summary: This study demonstrates that Nimbolide nanoparticles can effectively inhibit triple-negative breast cancer stem cells, involving epigenetic reprogramming of DNA methyltransferases and inhibition of the Wnt/β-catenin signaling pathway. In in vivo experiments, Nimbolide nanoparticles showed stronger anti-tumor and anti-metastatic effects compared to native Nimbolide.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Multidisciplinary Sciences
Xiaoling Leng, Guofu Huang, Siyi Li, Miaomiao Yao, Jianbing Ding, Fucheng Ma
Summary: There is a correlation between CEUS characteristics and EMT in breast cancer tissues, with certain markers up-regulated and others down-regulated. Some CEUS indicators are associated with clinical manifestations and disease prognosis in breast cancer.
Article
Pharmacology & Pharmacy
Nongyao Nonpanya, Kittipong Sanookpan, Nicharat Sriratanasak, Chanida Vinayanuwattikun, Duangdao Wichadakul, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Artocarpin targets FAK to suppress EMT and migratory behaviors of lung cancer cells, without affecting normal lung cells.
Article
Multidisciplinary Sciences
Madeline Galbraith, Herbert Levine, Jose N. Onuchic, Dongya Jia
Summary: Cancer metastasis relies on the coordination of metabolism and epithelial-mesenchymal transition (EMT), with hybrid metabolic phenotypes (W/O) and hybrid epithelial/mesenchymal phenotypes (E/M) associated with high metastatic potentials. The crosstalk between metabolism and EMT can have synergistic or antagonistic effects on the acquisition and stability of different coupled metabolism-EMT states. Our study highlights the mutual activation between metabolism and EMT, contributing to a better understanding of the complex nature of cancer metastasis.
Article
Multidisciplinary Sciences
Madelin Galbraith, Herbert Levine, Jose N. Onuchic, Dongya Jia
Summary: Cancer metastasis relies on the interaction between metabolic phenotypes (W/O) and epithelial-mesenchymal transition (EMT) states. The synergistic or antagonistic effects of their crosstalk can impact the stability and acquisition of different coupled metabolism-EMT states. The aggressive E/M-W/O state can be enabled and stabilized by the crosstalk between metabolism and EMT, irrespective of their individual availability.
Review
Chemistry, Medicinal
Sorayya Ghasemi, Suowen Xu, Seyed Mohammad Nabavi, Mohammad Amir Amirkhani, Antoni Sureda, Silvia Tejada, Zahra Lorigooini
Summary: Epigenetic alterations play a significant role in cancer development, especially in cancer stem cells (CSCs). Epigenetic therapies targeting CSCs are emerging as a promising strategy for cancer treatment, with phenolic compounds potentially neutralizing CSCs development and metabolism through epigenetic mechanisms.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wan Hua, Sarantos Kostidis, Oleg Mayboroda, Martin Giera, Marten Hornsveld, Peter ten Dijke
Summary: TGF-beta induces metabolic reprogramming in epithelial cells during EMT, affecting glycolysis, TCA cycle, glutaminolysis, choline metabolism, cellular redox state, and other pathways. Inhibiting choline kinase alpha with a kinase inhibitor can attenuate TGF-beta-induced changes associated with EMT.
Review
Oncology
Evan M. McCabe, Theodore P. Rasmussen
Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Steven Vermeulen, Bart Van Puyvelde, Laura Bengtsson del Barrio, Ruben Almey, Bernard K. K. van der Veer, Dieter Deforce, Maarten Dhaenens, Jan de Boer
Summary: This study investigates how surface topography influences nuclear morphology, histone modifications, and gene expression. The authors find that micro-topographies result in a loss of histone acetylation and nucleoli abundance, as well as a reduction in gene expression associated with chromosome organization. They also show that micro-topographies can influence the proliferation and phenotype of mesenchymal stem cells, and this effect is reversible.
Article
Oncology
Jeroen Verstappe, Geert Berx
Summary: Stem cells have the ability to self-renew and give rise to differentiated cells, playing important roles in maintaining tissue homeostasis and injury repair. Cancer stem cells, which exhibit stem-like properties, are responsible for tumor growth, metastasis, and relapse. The process of epithelial-to-mesenchymal transition (EMT) is correlated with stemness in both normal and cancer cells, indicating the acquisition of stemness is not intrinsic. Recent studies show that hybrid EMT states have a higher likelihood of acquiring stem cell traits. The position of a cell along the EMT axis, known as the stemness window, determines the EMT/MET inducing programs required to reach stemness.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Environmental Sciences
Qi Qin, Bingwei Yang, Zixuan Liu, Lei Xu, Erqun Song, Yang Song
Summary: The study found that the metabolite PCB29-pQ of polychlorinated biphenyls can induce the metastasis of breast cancer by increasing the expression of cancer stem cell markers and activating the Wnt/beta-catenin pathway, with the overproduction of reactive oxygen species playing a key role in this process.
Review
Oncology
Bing Dong, Shiyu Li, Shuangli Zhu, Ming Yi, Suxia Luo, Kongming Wu
Summary: Cancer stem cells (CSCs) play a crucial role in tumorigenesis and cancer progression, with their generation believed to be driven by epithelial-to-mesenchymal transition (EMT). MicroRNAs (miRNAs) have been found to be key players in this process, and regulating miRNAs associated with EMT or CSCs may help overcome drug resistance.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Charlene Waryah, Joseph Cursons, Momeneh Foroutan, Christian Pflueger, Edina Wang, Ramyar Molania, Anabel Sorolla, Christopher Wallis, Colette Moses, Irina Glas, Leandro Magalhaes, Erik W. Thompson, Liam G. Fearnley, Christine L. Chaffer, Melissa Davis, Anthony T. Papenfuss, Andrew Redfern, Ryan Lister, Manel Esteller, Pilar Blancafort
Summary: This work successfully silenced ZEB1 in triple negative breast cancer (TNBC) models through CRISPR/dCas9-mediated epigenetic editing, leading to significant tumor inhibition and the discovery of ZEB1-dependent-signature genes. Epigenetic changes, including reactivation and enhanced chromatin accessibility, were observed in cell adhesion loci, indicating a shift towards a more epithelial state. Silencing of ZEB1 also induced heterochromatin expansion, DNA methylation changes, and chromatin modifications in the ZEB1 promoter. This study demonstrated the potential of epigenome-engineering approaches and customizable precision molecular oncology for targeting poor outcome breast cancers.
Article
Oncology
Ji-Yong Sung, Jae-Ho Cheong
Summary: Genomic classification has identified a distinct molecular subtype of clinically refractory cancers associated with EMT. Metabolic profiling across different cancer types revealed high carbohydrate and energy metabolism linked to high EMT activity in 80 to 90% of cases. CHST14 was highlighted as a potential metabolic target for stomach cancer, indicating the importance of metabolism-associated genes in targeting therapy for cancer subtypes.
