Article
Clinical Neurology
Valerian L. Altersberger, Lukas S. Enz, Gerli Sibolt, Christian Hametner, Stefania Nannoni, Mirjam R. Heldner, Jeffrey Stolp, Dejana R. Jovanovic, Andrea Zini, Alessandro Pezzini, Susanne Wegener, Carlo W. Cereda, George Ntaios, Silja Raety, Christoph Gumbinger, Miriam Heyse, Alexandros A. Polymeris, Annaelle Zietz, Anna Schaufelbuehl, Davide Strambo, Giovanna Padlina, Nedelina Slavova, Marjaana Tiainen, Kati Valkonen, Twan J. van Velzen, Guido Bigliardi, Predrag Stanarcevic, Mauro Magoni, Andreas Luft, Yannick Bejot, Laura Vandelli, Visnja Padjen, Paul J. Nederkoorn, Marcel Arnold, Patrik Michel, Peter A. Ringleb, Sami Curtze, Stefan T. Engelter, Henrik Gensicke
Summary: The study aims to investigate the prognostic value of white blood cell count (WBC) on functional outcome, mortality, and bleeding risk in stroke patients treated with intravenous thrombolysis (IVT). The results showed that leukocytosis independently predicted poor functional outcome and death, but was not associated with bleeding complications after IVT.
JOURNAL OF NEUROLOGY
(2022)
Article
Pediatrics
Maria Victoria Rodriguez-Benitez, Reyes Gamez-Belmonte, Mercedes Gil-Campos, Cristina Hernandez-Chirlaque, Paula R. Bouzas, Fermin Sanchez de Medina, Olga Martinez-Augustin
Summary: This study investigated the inflammatory status of preterm children, showing increased neutrophil markers and decreased AP in meconium, as well as elevated levels of some proinflammatory cytokines and growth factors in plasma, correlating with birth weight and gestational age. Preterm infants also exhibited neutropenia and decreased adiponectin, leptin, haematocrit, and hemoglobin, with some parameters correlating positively with GA and BW, while others showed negative correlations. Postnatal morbidity in preterm children was associated with increased MPO and MIP-1 alpha.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Yuek Ling Chai, Jasinda H. H. Lee, Joyce R. R. Chong, Clive Ballard, Paul T. Francis, Brian K. Kennedy, Thiruma V. Arumugam, Christopher P. P. Chen, Dag Aarsland, Mitchell K. P. Lai
Summary: This study compared the neuroinflammatory responses in Alzheimer's disease (AD) and Lewy body dementias (LBD). The findings showed elevated levels of inflammatory mediators in the brains of AD patients, while there were no significant changes in LBD patients. Furthermore, the increase in neuroinflammatory markers was associated with neurofibrillary tangle burden in AD, but not in LBD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, General & Internal
Giacomo Tondo, Davide Aprile, Fabiola De Marchi, Barbara Sarasso, Paola Serra, Giordana Borasio, Esther Rojo, Juan Francisco Arenillas, Cristoforo Comi
Summary: Growing evidence suggests that neuroinflammation plays a critical role in neurodegenerative diseases. Peripheral markers of inflammation, such as the neutrophil-to-lymphocyte ratio (NLR), could be used as reliable indicators of central nervous system inflammation. However, the role of peripheral inflammation in dementia and MCI needs further clarification.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Emma L. van der Ende, Estrella Morenas-Rodriguez, Corey McMillan, Murray Grossman, David Irwin, Raquel Sanchez-Valle, Caroline Graff, Rik Vandenberghe, Yolande A. L. Pijnenburg, Robert Laforce, Isabelle Le Ber, Alberto Lleo, Christian Haass, Marc Suarez-Calvet, John C. van Swieten, Harro Seelaar
Summary: Excessive microglial activation may play a central role in GRN-related frontotemporal dementia. sTREM2 levels were measured in cerebrospinal fluid of presymptomatic and symptomatic GRN and C9orf72 mutation carriers, as well as healthy noncarriers, revealing high levels in a subset of GRN carriers. While sTREM2 is not a promising diagnostic biomarker, it may have potential in monitoring microglial activity and predicting disease progression.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Jessica Samuelsson, Anna Marseglia, Olof Lindberg, Eric Westman, Joana B. Pereira, Sara Shams, Silke Kern, Felicia Ahlner, Elisabet Rothenberg, Ingmar Skoog, Anna Zettergren
Summary: This study found associations between dietary patterns and dementia-related neuroimaging markers. Specifically, a high-protein and alcohol pattern was negatively associated with cortical thickness, while a Mediterranean-like pattern was positively associated with white matter microstructural integrity. No associations were found with a Western-like pattern.
ALZHEIMERS & DEMENTIA
(2023)
Article
Virology
Kate Stoeckle, Britta Witting, Shashi Kapadia, Anjile An, Kristen Marks
Summary: The antiviral drug remdesivir has been found to reduce hospital stay duration in COVID-19 patients needing oxygen, but some patients worsen despite treatment. A study identified potential prognostic factors in remdesivir-treated patients, showing higher inflammatory markers in those who deteriorated. Further research into treatment strategies modifying the inflammatory response is supported.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Nutrition & Dietetics
Sixtus Aguree, Manju B. Reddy
Summary: Limited evidence suggests dysregulation of serum iron and hepcidin concentrations in obesity and inflammation. This study compared inflammatory markers, serum lipids, and iron status between obese and normal-weight women. Obese women showed higher levels of inflammation, triglycerides, and hepcidin, but lower HDL and serum iron/hepcidin ratio compared to normal-weight women. BMI correlated positively with inflammatory markers, triglycerides, and total cholesterol/HDL ratio, and negatively with HDL and serum iron/hepcidin ratio.
Article
Immunology
Katja Dittrich, Katja Boedeker, Dorothea Kluczniok, Catherine Hindi Attar, Sibylle M. Winter, Stefan Roepke, Christine Heim, Sabine C. Herpertz, Felix Bermpohl
Summary: The study examines the association between major depressive disorder (MDD) and inflammation markers, suggesting that elevated levels of inflammation may persist even after MDD remission. Results indicate that physical abuse predicts CRP levels in the presence of remitted MDD, highlighting the potential influence of different types of early life maltreatment on inflammation profiles.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Endocrinology & Metabolism
Maria Krajewska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Anna Stelmaszczyk-Emmel, Maria Sobol, Anna Majcher, Beata Pyrzak
Summary: The study found that vitamin D supplementation had beneficial effects in overweight and obese children, reducing inflammation levels and stabilizing anti-inflammatory cytokines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Paul Campbell, Trishna Rathod-Mistry, Michelle Marshall, James Bailey, Carolyn A. Chew-Graham, Peter Croft, Martin Frisher, Richard Hayward, Rashi Negi, Swaran Singh, Shula Tantalo-Baker, Suhail Tarafdar, Opeyemi O. Babatunde, Louise Robinson, Athula Sumathipala, Nwe Thein, Kate Walters, Scott Weich, Kelvin P. Jordan
Summary: The study identified 63 markers of dementia-related health mapped to 13 domains, with comorbidity and home pressures being the most and least prevalent domains in dementia patients. These markers provide valuable insights into the challenges faced by dementia patients in their daily lives and could be used to identify individuals at risk of faster progression.
AGING & MENTAL HEALTH
(2021)
Article
Clinical Neurology
Vanessa G. Fraga, Claudia N. Ferreira, Flavia R. Oliveira, Ana Lucia Candido, Maria das Gracas Carvalho, Fernando M. Reis, Paulo Caramelli, Leonardo C. De Souza, Karina B. Gomes
Summary: The study found no difference in peripheral levels of irisin between patients with behavioral variant frontotemporal dementia (bvFTD) and controls, but in the bvFTD group, irisin levels were positively correlated with IL-6 and TNF concentrations.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Katarzyna Komosinska-Vassev, Aleksandra Kaluzna, Agnieszka Jura-Poltorak, Alicja Derkacz, Krystyna Olczyk
Summary: The aim of this research was to find new biomarkers for inflammatory bowel diseases (IBD). The results showed that serum concentrations of laminin, fibronectin, and gelatinase-associated lipocalin were associated with disease activity, indicating their potential as additional tools for diagnosing and monitoring IBD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler
Summary: The study revealed that in patients with T2D, there was an exacerbation of AD-associated protein changes induced by hypoglycaemia, with elevated APP and decreased SNCA. Other proteins levels affected by hypoglycaemia, particularly in T2D, included amyloid P-component, microtubule-associated protein tau, apolipoproteins A1 and E3, pappalysin, and noggin, aligning with the reported negative effects of hypoglycaemia.
DIABETES OBESITY & METABOLISM
(2021)
Article
Critical Care Medicine
Rene S. Bermea, Yuval Raz, Federico Sertic, Jonah Rubin, Molly Wolf, Salim Olia, Thomas Richards, Jerome Crowley, Masaki Funamoto, Kenneth Shelton, Christian Bermudez
Summary: The study evaluated the incidence and etiology of intracranial hemorrhage (ICH) in COVID-19 patients requiring ECMO support, with all ICH events occurring in patients who received intravenous anticoagulation. Patients with ICH had higher levels of inflammatory markers and lower blood pH, as well as higher activated partial thromboplastin times.ICH-free survival was lower in COVID-19 patients compared to those with other viral respiratory infections.