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Serum high-density lipoprotein cholesterol levels, their relationship with baseline functional and cognitive status, and their utility in predicting mortality in nonagenarians

GERIATRICS & GERONTOLOGY INTERNATIONAL (2011)

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GERIATRICS & GERONTOLOGY INTERNATIONAL

卷 11, 期 3, 页码 358-364

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WILEY

DOI: 10.1111/j.1447-0594.2010.00681.x

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high-density lipoprotein cholesterol; mortality; nonagenarians; physical function

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Geriatrics & Gerontology Gerontology

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Aim: Little is known about the role of high-density lipoprotein cholesterol (HDL-C) in oldest-old subjects. The aim of this study is to evaluate the association between HDL-C levels and physical and cognitive performance indicators in nonagenarians, and also to determine the influence of HDL-C levels on the 3-year mortality risk. Methods: The data analyzed were taken from the NonaSantfeliu Study. Functional status was determined by the Lawton-Brody Index (LI) for instrumental activities of daily living (IADL) and the Barthel Index (BI) for basic activities (BADL). Cognition was assessed using the Spanish version of the Mini-Mental State Examination (MEC). Results: The sample consisted of 49 women (79%) and 13 men, aged 94.3 +/- 2.6 years. Mean HDL-C levels were 60 +/- 16 mg/dL, and 16 subjects (25.8%) had low HDL-C values. HDL-C levels did correlate with BI (r = 0.28, P = 0.02) and LI (r = 0.32, P = 0.01), but not with MEC (r = 0.18, P = 0.15). Normal HDL-C levels at baseline were significantly associated with higher BI scores (P < 0.006, odds ratio [OR] = 1.03, 95% confidence interval [CI] = 1.01-1.05) and a lower number of prescription drugs used (P < 0.04, OR = 0.71, 95% CI = 0.49-0.99). Baseline HDL-C levels were significantly lower among the group of nonagenarians who died within the 3 years of follow up (P = 0.02). However, after adjusting for potential confounders, the association between HDL-C and mortality lost significance. Conclusion: Higher levels of HDL-C correlate with better functional status and less use of prescribed drugs in nonagenarians. However, the relationship between low HDL-C levels and long-term mortality in this population remains unclear. Geriatr Gerontol Int 2011; 11: 358-364.

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Higher Serum Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio Is Associated with Increased Mortality among Incident Peritoneal Dialysis Patients

Hee-Won Noh, Yena Jeon, Ji-Hye Kim, Ga-Young Lee, Soo-Jee Jeon, Kyu-Yeun Kim, Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho

Summary: This study found that the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) is associated with mortality in peritoneal dialysis patients. Patients with higher TC/HDL-C had higher body mass index, diabetes prevalence, and serum albumin level. However, individual levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were not associated with mortality.

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