期刊
JOURNAL OF VIROLOGY
卷 89, 期 19, 页码 10125-10129出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01606-15
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资金
- Japan Society for the Promotion of Science (JSPS)
We identified two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to hCD134. Murine CD134 (mCD134) functioned as an HHV-6B receptor when these two amino acid residues were replaced with homologous human residues. This study identifies both the HHV-6B receptor-ligand interaction and the species-specific determinants of hCD134 essential for HHV-6B entry.
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