Article
Cell Biology
Conner Kummerlowe, Simutanyi Mwakamui, Travis K. Hughes, Nolawit Mulugeta, Victor Mudenda, Ellen Besa, Kanekwa Zyambo, Jessica E. S. Shay, Ira Fleming, Marko Vukovic, Ben A. Doran, Toby P. Aicher, Marc H. Wadsworth, Juliet Tongue Bramante, Amiko M. Uchida, Rabiah Fardoos, Osaretin E. Asowata, Nicholas Herbert, Omer H. Yilmaz, Henrik N. Kloverpris, John J. Garber, Jose Ordovas-Montanes, Zev J. Gartner, Thomas Wallach, Alex K. Shalek, Paul Kelly
Summary: Environmental enteropathy (EE) is a subclinical condition of the small intestine that is highly prevalent in low- and middle-income countries. This study used single-cell RNA sequencing to analyze the cellular and molecular correlates of EE. The results showed that the transcriptional signatures of EE may be driven by an increased abundance of surface mucosal cells and identified dysregulated signaling pathways and increased proinflammatory cytokine gene expression in EE epithelium.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Fangshu Yao, Kepu Chen, Yiyun Zhuang, Xueer Shen, Xiaochun Wang
Summary: The study found that the menstrual cycle can affect women's olfactory function, with better olfactory discrimination performance observed during the mid-luteal phase. Additionally, better olfactory discrimination and worse olfactory threshold in the mid-luteal phase may predict fewer emotional symptoms and lower behavioral impulsivity, respectively.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Eduard Maury-Sintjago, Alejandra Rodriguez-Fernandez, Julio Parra-Flores, Marcela Ruiz-De la Fuente
Summary: The aim of the study was to determine the association between menstrual cycle phase and resting metabolic rate (RMR) as well as dietary intake. The results showed that lean women had increased RMR, caloric intake, and lipid intake during the luteal phase, while women with obesity only had increased carbohydrate intake.
Article
Food Science & Technology
Yuanjie Guo, Yu Ma, Liyuan Ma, Zixin Guo, Yingliang Xiao, Yunjun Liu, Jie Li, Shengnan Wang, Yixiang Liu
Summary: The study found that oleuropein can prevent food allergies by enhancing intestinal epithelial barrier function, improving immune homeostasis, and regulating intestinal flora. Diets rich in oleuropein are recommended for individuals with food allergies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Endocrinology & Metabolism
Darwin A. Guevarra, Courtney C. Louis, Lilianne M. Gloe, Stefanie Russman Block, Deborah A. Kashy, Kelly L. Klump, Jason S. Moser
Summary: The study found increased anhedonic depression in the mid-luteal phase of the menstrual cycle for women, but no significant changes in anxious apprehension and anxious arousal. Additionally, there was a positive association between stress and anxious apprehension as well as anhedonic depression, but not anxious arousal. These associations were not stronger in the mid-luteal phase, providing weak evidence for a window of vulnerability for affective symptoms during this phase.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Malihe Eskandari Torbaghan, Ali Moghimi, Hamid Reza Kobravi, Masoud Fereidoni, Imanollah Bigdeli
Summary: This study aimed to investigate the effect of estradiol on stress and effect of stress on spatial working memory during the menstrual cycle. The results showed that estradiol levels decreased in the late follicular, luteal, and early follicular phases, while galvanic skin response decreased after stress induction in all three phases. Spatial working memory diminished after stress induction in all three phases, but increased in the late follicular phase. Average power spectrum density in all frequency bands increased after stress induction in the frontal and prefrontal channels. Therefore, stress led to spatial working memory dysfunction, while estradiol improved spatial working memory performance in the late follicular phase.
BRAIN AND BEHAVIOR
(2023)
Article
Obstetrics & Gynecology
Alan Penzias, Ricardo Azziz, Kristin Bendikson, Tommaso Falcone, Karl Hansen, Micah Hill, William Hurd, Sangita Jindal, Suleena Kalra, Jennifer Mersereau, Catherine Racowsky, Robert Rebar, Richard Reindollar, Anne Steiner, Cigdem Tanrikut, Dale Stovall, Hugh Taylor, Belinda Yauger, Molly Moravek, Steven Young
Summary: Luteal phase deficiency (LPD) is a clinical diagnosis characterized by an abnormal luteal phase length, with potential causes including inadequate progesterone duration, levels, or resistance. LPD may not necessarily cause infertility or recurrent pregnancy loss, and there is controversy surrounding the diagnosis and treatment proposals.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Lucia B. Palmero, Victor Martinez-Perez, Miriam Tortajada, Guillermo Campoy, Luis J. Fuentes
Summary: This study assessed the effects of progesterone on vigilance tasks and differentiated between exogenous and endogenous components. The results showed that Morning-type females performed better during the mid-luteal phase, while Evening-type females performed worse.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Kyoko Oshina, Keiji Kuroda, Kazuhiko Nakabayashi, Junko Tomikawa, Mari Kitade, Rikikazu Sugiyama, Kenichiro Hata, Atsuo Itakura
Summary: Chronic endometritis (CE) is characterized by persistent inflammation of the endometrium with the presence of plasma cell infiltration. CD138 immunohistochemistry is an effective diagnostic tool for CE. This study identified gene expression signatures associated with CE and potential new biomarkers using RNA-sequencing analysis.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Lubomira Izakova, Natasa Hlavacova, Daniela Jezova
Summary: The study found that in the early luteal phase of the menstrual cycle, salivary aldosterone concentrations were significantly higher in women with PMS compared to controls, while cortisol concentrations remained unchanged. This suggests that evening aldosterone levels may play an important role in the development of PMS symptoms.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Immunology
Luxin Pei, Kiyoshi F. Fukutani, Rafael Tiburcio, Adam Rupert, Eric W. Dahlstrom, Frances Galindo, Elizabeth Laidlaw, Andrea Lisco, Maura Manion, Bruno B. Andrade, Irini Sereti
Summary: The study identified metabolic disturbances in IRIS before and during the event, linking oxidative stress, tryptophan pathway, and lipid signaling with IRIS development. Metabolic pathways of lipids and amino acids were significantly associated with inflammatory biomarkers like IL-12p70 and IL-8 during the IRIS event, suggesting the impact of cellular metabolism on immune cell activation and vice versa.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Microbiology
Erica Andersen-Nissen, Andrew Fiore-Gartland, Lamar Ballweber Fleming, Lindsay N. Carpp, Anneta F. Naidoo, Michael S. Harper, Valentin Voillet, Nicole Grunenberg, Fatima Laher, Craig Innes, Linda-Gail Bekker, James G. Kublin, Ying Huang, Guido Ferrari, Georgia D. Tomaras, Glenda Gray, Peter B. Gilbert, M. Juliana McElrath
Summary: The pox-protein regimen tested in the RV144 trial is the only vaccine strategy that can prevent HIV-1 infection and activates type I and II interferon signaling pathways. Early innate immune transcriptional signatures identified after RV144 vaccination are associated with subsequent adaptive immune responses, which play a role in HIV-1 acquisition risk.
Review
Cell Biology
Yuxiang Du, Bo Yan
Summary: The retinal pigment epithelium is crucial for maintaining ocular immune privilege by using various mechanisms to suppress immune responses and prevent inflammation. This review focuses on the role of retinal pigment epithelium cells in immune regulation, particularly the changes that occur under pathological conditions.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Hiroshi Mitao, Toshiyuki Yoshizato, Tomoyuki Fujita, Mayumi Fukagawa, Akira Nakashima, Takashi Horinouchi, Kimio Ushijima
Summary: This study aimed to describe the physiological changes in endometrial blood flow from ovulation to the mid-luteal phase using superb microvascular imaging. The results showed a decrease in endometrial blood flow from ovulation to D5-7 after ovulation in the normal menstrual cycle, and the endometrial thickness in the ovulatory phase was related to endometrial perfusion.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Immunology
Kelly B. Arnold, Amy W. Chung
Article
Critical Care Medicine
David N. O'Dwyer, Shanna L. Ashley, Stephen J. Gurczynski, Meng Xia, Carol Wilke, Nicole R. Falkowski, Katy C. Norman, Kelly B. Arnold, Gary B. Huffnagle, Margaret L. Salisbury, MeiLan K. Han, Kevin R. Flaherty, Eric S. White, Fernando J. Martinez, John R. Erb-Downward, Susan Murray, Bethany B. Moore, Robert P. Dickson
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Cell & Tissue Engineering
Katy C. Norman, Christine M. Freeman, Neha S. Bidthanapally, MeiLan K. Han, Fernando J. Martinez, Jeffrey L. Curtis, Kelly B. Arnold
CELLULAR AND MOLECULAR BIOENGINEERING
(2019)
Article
Multidisciplinary Sciences
Katy C. Norman, David N. O'Dwyer, Margaret L. Salisbury, Katarina M. DiLillo, Vibha N. Lama, Meng Xia, Stephen J. Gurczynski, Eric S. White, Kevin R. Flaherty, Fernando J. Martinez, Susan Murray, Bethany B. Moore, Kelly B. Arnold
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Daniel L. Matera, Katarina M. DiLillo, Makenzee R. Smith, Christopher D. Davidson, Ritika Parikh, Mohammed Said, Carole A. Wilke, Isabelle M. Lombaert, Kelly B. Arnold, Bethany B. Moore, Brendon M. Baker
Article
Immunology
Achieng Tago, Lyle R. McKinnon, Tabitha Wanjiru, Festus Muriuki, Julius Munyao, Gloria Gakii, Maureen Akolo, Anthony Kariri, Neil Reed, Souradet Y. Shaw, Lawrence J. Gelmon, Joshua Kimani
Summary: This study analyzed the time trends of HIV prevalence in female sex workers (FSWs) accessing services at Sex Worker Outreach Programme (SWOP) clinics in Nairobi, and found that HIV prevalence decreased over time in all age groups. Adjusted analyses showed that compared with 2008, HIV prevalence significantly decreased from 2011 to 2017.
Article
Engineering, Biomedical
Claire E. Tomaszewski, Katarina M. DiLillo, Brendon M. Baker, Kelly B. Arnold, Ariella Shikanov
Summary: In this study, synthetic matrices functionalized with ECM-sequestering peptides improved follicle survival, growth, and maturation compared to inert controls. The peptides facilitated deposition and retention of cell-secreted ECM molecules, promoting healthy organoid development. The biomimetic material holds promise for tissue engineering applications by allowing encapsulated cells to rebuild their native microenvironments in vitro.
ACTA BIOMATERIALIA
(2021)
Article
Infectious Diseases
Souradet Y. Shaw, Lawrence J. Elliott, Deborah L. Nowicki, Christopher G. Green, Craig P. Ross, Joss N. Reimer, John L. Wylie, Pierre J. Plourde, Sevgi O. Aral, Marissa L. Becker, James F. Blanchard
Summary: The study demonstrated increasing rates of chlamydia and gonorrhea in Winnipeg from 2007 to 2016, with each pathogen occupying different ecological niches. Gonorrhea showed signs of geographic dispersion during a growth phase, resembling the distribution of chlamydia. Understanding these ecological niches can help in better targeting vulnerable subpopulations for STI prevention and control efforts.
SEXUALLY TRANSMITTED DISEASES
(2021)
Article
Immunology
Souradet Y. Shaw, Laurie Ireland, Leigh M. McClarty, Carla Loeppky, Jared Bullard, Paul Van Caeseele, Yoav Keynan, Ken Kasper, Stephen Moses, James F. Blanchard, Marissa L. Becker
Summary: This study analyzed healthcare utilization among HIV-positive individuals and found that in the 2 years prior to HIV diagnosis, these patients were more likely to be diagnosed with blood disorders, treated for mood disorders, and have more hospital visits. Opportunities exist for prevention, screening, and earlier diagnosis, highlighting the importance of integrating healthcare services with public health.
INTERNATIONAL JOURNAL OF STD & AIDS
(2022)
Review
Biochemistry & Molecular Biology
Christina Y. Lee, Lillian R. Dillard, Jason A. Papin, Kelly B. Arnold
Summary: The mechanisms associated with optimal and non-optimal states of the vaginal microbiome (VMB) remain poorly understood due to its complex community structure and dynamic nature. Statistical methods have improved understanding of VMB composition and function, but mechanistic models using a priori knowledge of VMB features are underutilized. This review discusses systems biology approaches that have been applied to the VMB, highlighting successful techniques and new directions for improved understanding of health and disease.
TRENDS IN MICROBIOLOGY
(2023)
Article
Immunology
Souradet Y. Shaw, Neil Reed, Tabitha Wanjiru, Festus Muriuki, Julius Munyao, Maureen Akolo, Achieng Tago, Lawrence Gelmon, Joshua Kimani, Lyle R. McKinnon
Summary: Kenya's HIV epidemic is heterogeneously distributed, with targeted interventions needed for female sex workers. Geospatially informed approaches were used to quantify heterogeneity in HIV burden in Nairobi-based FSWs by place of origin and hotspots. The study found significant variations in HIV prevalence among FSWs in Nairobi based on their origin and hotspots, highlighting the importance of tailored interventions.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Public, Environmental & Occupational Health
Souradet Y. Shaw, Elsabe du Plessis, Rudy Broers, Sugirtha Vasavithasan, Saadya Hamdani, Lisa Avery
Summary: South Asia has a high burden of maternal mortality, particularly among adolescents. Bangladesh, with one of the highest rates of adolescent pregnancy, has low utilization of maternal newborn and child health (MNCH) services, hindering progress towards achieving optimal health outcomes. Male partner involvement is crucial in improving access to services and decision-making. Limited data exists on male involvement in MNCH service uptake in South Asia. The Strengthening Health Outcomes for Women and Children project by Plan International aimed to address these issues. Study results showed that higher maternal education levels were associated with use of MNCH services. After controlling for maternal education, service uptake was linked to male partner support and joint decision-making. These findings suggest the importance of structural-level interventions targeting both women and their male partners for achieving optimal MNCH outcomes.
GLOBAL PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Krista Wilkinson, Xuan Chen, Souradet Shaw
Summary: Understanding the important transmission parameters of COVID-19, such as secondary attack rates, can help in planning interventions. A study in Winnipeg Health Region found a secondary attack rate of 14.7% among household contacts of COVID-19 cases.
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2021)
Article
Family Studies
Jason D. Edgerton, Souradet Shaw, Lance W. Roberts
EMERGING ADULTHOOD
(2019)
Article
Materials Science, Biomaterials
Claire E. Tomaszewski, Elizabeth Constance, Melissa M. Lemke, Hong Zhou, Vasantha Padmanabhan, Kelly B. Arnold, Ariella Shikanov
BIOMATERIALS SCIENCE
(2019)