期刊
GENOMICS
卷 99, 期 1, 页码 44-51出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2011.09.003
关键词
Retina; Transcriptome; RNA-seq; Mouse; Alternative splicing
资金
- Center for Vision Research at Brown University
- NIMH [K23 MH080954-05]
- NIH [S10 RR027634-01, P30 RR031153-01A1]
- R NIH [P20 RR018728-10]
Genome-wide characterization of the retinal transcriptome is central to understanding development, physiology and disorders of the visual system. Massively parallel, short-read sequencing of mRNA libraries was used to generate an extensive map of the transcriptome of the adult, murine neural retina. RNA-seq data strongly corroborates prior transcriptome studies by microarray and SAGE. However, several novel features of the retinal transcriptome were discovered. For example, retinal disease genes were discovered to be among the most highly expressed in the transcriptome. We also demonstrate other interesting features of the retinal transcriptome, for example, that the retina appears to employ a very specific and restricted set of synaptic vesicle genes, and also that there is persistence of expression of a majority of neurodevelopmental genes into adulthood. Retina transcriptome studies utilizing novel sequencing methods have been highly informative and these data may also serve as a resource for the community of researchers. (C) 2011 Elsevier Inc. All rights reserved.
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