The Evolution of the GPCR Signaling System in Eukaryotes: Modularity, Conservation, and the Transition to Metazoan Multicellularity

A Genomic Survey of HECT Ubiquitin Ligases in Eukaryotes Reveals Independent Expansions of the HECT System in Several Lineages

(2013) Xavier Grau-Bové et al.   Genome Biology and Evolution

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The maize Gα gene COMPACT PLANT2 functions in CLAVATA signalling to control shoot meristem size

(2013) Peter Bommert et al.   NATURE

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein   subunits

(2013) P. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

(2013) R. Kataria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic G Protein Signaling Evolved to Require G Protein-Coupled Receptors for Activation

(2013) W. Bradford et al.   Science Signaling

Aggregative Multicellularity Evolved Independently in the Eukaryotic Supergroup Rhizaria

(2012) Matthew W. Brown et al.   CURRENT BIOLOGY

Ric-8: Different cellular roles for a heterotrimeric G-protein GEF

(2012) M.V. Hinrichs et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Origin and Evolution of G Protein-Coupled Receptor Kinases

(2012) Arcady Mushegian et al.   PLoS One

The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi

(2012) Arunkumar Krishnan et al.   PLoS One

The evolutionary history of haptophytes and cryptophytes: phylogenomic evidence for separate origins

(2012) F. Burki et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases

(2012) H. Suga et al.   Science Signaling

Premetazoan Origin of the Hippo Signaling Pathway

(2012) Arnau Sebé-Pedrós et al.   Cell Reports

G Protein Activation without a GEF in the Plant Kingdom

(2012) Daisuke Urano et al.   PLoS Genetics

Two-Component Systems and Their Co-Option for Eukaryotic Signal Transduction

(2011) G. Eric Schaller et al.   CURRENT BIOLOGY

Rooting the Eukaryotic Tree with Mitochondrial and Bacterial Proteins

(2011) R. Derelle et al.   MOLECULAR BIOLOGY AND EVOLUTION

Phylogenetic Relationships within the Opisthokonta Based on Phylogenomic Analyses of Conserved Single-Copy Protein Domains

(2011) G. Torruella et al.   MOLECULAR BIOLOGY AND EVOLUTION

Independent HHsearch, Needleman-Wunsch-Based, and Motif Analyses Reveal the Overall Hierarchy for Most of the G Protein-Coupled Receptor Families

(2011) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

The Pfam protein families database

(2011) M. Punta et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling

(2011) S. B. Liggett   Science Signaling

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton

(2010) Bill Wickstead et al.   BMC EVOLUTIONARY BIOLOGY

The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility

(2010) Lillian K. Fritz-Laylin et al.   CELL

Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system

(2010) Vivek Anantharaman et al.   GENE

PhyloBayes 3: a Bayesian software package for phylogenetic reconstruction and molecular dating

(2009) Nicolas Lartillot et al.   BIOINFORMATICS

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

(2009) Eve Gazave et al.   BMC EVOLUTIONARY BIOLOGY

The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling

(2009) Garret R. Anderson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

The fifth class of G  proteins

(2009) Y. Oka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origins of Multicellularity and the Early History of the Genetic Toolkit For Animal Development

(2008) Antonis Rokas   Annual Review of Genetics

On the origins of arrestin and rhodopsin

(2008) Carlos E Alvarez   BMC EVOLUTIONARY BIOLOGY

The Secretin GPCRs Descended from the Family of Adhesion GPCRs

(2008) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

(2008) Nicole King et al.   NATURE

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

(2008) Yusuke Maeda et al.   NATURE CELL BIOLOGY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

(2008) G. Manning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heterotrimeric G-proteins: a short history

(2006) Graeme Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY