Article
Biochemistry & Molecular Biology
Thibault Latrille, Vincent Lanore, Nicolas Lartillot
Summary: Mutation-selection phylogenetic codon models are a principled approach for studying the interplay between mutation, selection, and drift, but their assumption of constant genetic drift is unrealistic. By introducing variation in effective population size and mutation rate between lineages, the model can better account for the joint evolutionary process of these lineage-specific variables. The model, tested on simulated and empirical data, suggests reasonable reconstructions of evolutionary trends, although potential issues with assumptions about epistatic interactions between sites remain.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Review
Microbiology
Weilong Hao
Summary: Analysis of genome variation is crucial for understanding the mechanisms of genome evolution. Mitochondrial genomes are excellent models for studying variation mechanisms due to their substantial variation in various genomic aspects. Recent research on yeast mitogenomes has provided valuable insights into molecular mechanisms in genome evolution.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Clinical Neurology
Nicholas E. Johnson, Russell J. Butterfield, Katie Mayne, Tara Newcomb, Carina Imburgia, Diane Dunn, Brett Duval, Marcia L. Feldkamp, Robert B. Weiss
Summary: This study found that the prevalence of CTG repeat expansions in the DMPK gene associated with DM1 is up to 5 times higher than previously reported estimates, with 4.76 DM1 cases per 10,000 births and 19.1 cases in the premutation range per 10,000 births in newborns in New York. This suggests that DM1 may be underdiagnosed in practice.
Article
Microbiology
Jovan Komluski, Michael Habig, Eva H. Stukenbrock
Summary: This study sequenced the four meiotic products for 23 individual meioses and determined the genetic changes caused by meiosis for the important fungal wheat pathogen Zymoseptoria tritici. It was found that meiosis is associated with genetic changes in the genome through recombination, gene conversion, and mutations. The occurrence of gene conversion and mutations during meiosis may be influenced by chromatin conformation, similar to the effect of chromatin conformation on the mitotic mutation rate.
Article
Microbiology
Stephanie van Wyk, Brenda D. Wingfield, Lieschen De Vos, Nicolaas A. van der Merwe, Emma T. Steenkamp
Summary: The RIP mutation pathway is a fungus-specific defense mechanism that introduces cytosine to thymine transitions in targeted sequences. Through genome-wide analysis in Ascomycota, it was found that most fungi had RIP mutations, especially in the Pezizomycotina classes. Extreme cases of RIP were limited to certain classes like Dothideomycetes and Sordariomycetes, while no evidence of RIP was found in Taphrinomycotina and Saccharomycotina genomes. Losses in RIP combined with controlled TE proliferation in certain groups may lead to genome enlargement and sub-genomic compartments.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Ecology
Krystyna Nadachowska-Brzyska, Mateusz Konczal, Wieslaw Babik
Summary: Effective population size (Ne) is a key evolutionary parameter that determines genetic variation levels and selection efficacy. Ne estimation and interpretation are essential in evolutionary and conservation biology, with diverse applications and methods available. Recent advancements in estimating temporal Ne trends provide a comprehensive understanding of the evolutionary continuum.
METHODS IN ECOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Nils Ryman, Linda Laikre, Ola Hossjer
Summary: Measurement of allele frequency shifts between temporally spaced samples has been used to estimate effective population size (N-e), also known as variance effective size (N-eV). Our study reveals that N-eV of a local population within a sub-structured population is influenced by genetic drift, migration rate (m), and census size (N-c). The relationship between N-e and N-c determines whether the realized N-eV of a local population increases or decreases with increasing m. The effect of N-c on N-eV is most significant at higher migration rates.
MOLECULAR ECOLOGY RESOURCES
(2023)
Letter
Biochemistry & Molecular Biology
Scott William Roy
Summary: The study suggests that most mammalian circRNAs may be functionless and costly, aligning with the Drift-Barrier Hypothesis where nonessential genomic elements are more abundant in species with small population sizes. The distinction between genomic elements created by small-scale mutations and larger, more idiosyncratic mutations is key to understanding the implications of the study for the Drift-Barrier Hypothesis.
JOURNAL OF MOLECULAR EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Irene Novo, Noelia Perez-Pereira, Enrique Santiago, Humberto Quesada, Armando Caballero
Summary: The availability of high-density markers allows the estimation of historical effective population size. Recent refinement methods have been shown to be accurate with simulation data and have been applied to real data of various species. An experimental design with Drosophila melanogaster was carried out to test the method, which showed generally good performance. The limitations of the method and its application were discussed.
MOLECULAR ECOLOGY RESOURCES
(2023)
Article
Biochemistry & Molecular Biology
Yujie Huang, Cong Liu, Chao Xiao, Xiaoying Chen, Xueli Han, Shaohua Yi, Daixin Huang
Summary: This study investigated the mutation rates of 28 autosomal STRs in the Chinese Han population, revealing relationships between STR mutation rates and factors such as population, sex, age, allele length, and heterozygosity. The results showed a higher frequency of paternal mutations compared to maternal mutations, an increase in mutation rate with paternal age, a bias towards contraction mutations for long alleles, and expansion mutations for short alleles, with no overall bias in mutation direction. Additionally, loci with higher expected heterozygosity tended to have higher mutation rates, providing valuable information for further research on STR mutations in forensic genetics.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Engineering, Chemical
Jingqi Ruan, Ming Zhang, Weizhen Shao, Hongqing Bo, Zhonglin Chen, Lijie Xu, Zhanghao Chen, Cheng Gu, Weichuan Qiao
Summary: The development of high-performance heterogeneous Fenton-like catalysts has enabled their practical application in various scenarios. In this study, a novel strategy using MXene-like 2D MOF-derived carbon loaded Fe3O4 nanoparticles was proposed to assemble NSC@Fe3O4 catalyst, which effectively removed target pollutants through size-exclusion effect. The degradation mechanism was hypothesized to be non-radical, dominated by O-1(2) and electron transfer. The toxicity of the target pollutant was reduced under the NSC@Fe3O4/PMS system.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Microbiology
Rita Milvia De Miccolis Angelini, Lucia Landi, Celeste Raguseo, Stefania Pollastro, Francesco Faretra, Gianfranco Romanazzi
Summary: This study compared the genomes of three Monilinia species, providing insights into their evolutionary relationships and features of transposable elements. It also revealed that Monilinia genus possesses multiple virulence mechanisms to infect host plants, with potentially species-specific pathogenic factors.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Mehmet Akif Gunen
Summary: The paper proposes an Omnivariance based adaptive neighborhood size selection method and a new feature set composed of 14 features for extraction of geometric features. The results demonstrate that combining the proposed optimum neighbor selection method and feature set with the Auto-Encoder classifier can achieve good classification performance on various datasets.
APPLIED SOFT COMPUTING
(2022)
Article
Evolutionary Biology
Erika King, Megan V. McPhee, Scott C. Vulstek, Curry J. Cunningham, Joshua R. Russell, David A. Tallmon
Summary: The impact of precocious males on effective population size (N-e) in Pacific salmon has been quantified in a naturally spawning population of Coho Salmon. The study found that precocial males (jacks) can influence N-b and N-e, and make a substantial contribution to population dynamics and conservation of threatened stocks.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Microbiology
Jiejing Tang, Zhe Sui, Ronghui Li, Yuping Xu, Lixuan Xiang, Shiying Fu, Jinfeng Wei, Xuan Cai, Mingde Wu, Jing Zhang, Weidong Chen, Yangdou Wei, Guoqing Li, Long Yang
Summary: The G beta-like protein gene Bcgbl1 in the gray mold fungus Botrytis cinerea regulates development and pathogenicity by interacting with the adapter protein of the cascade of MAP kinases (MAPK) and affecting phosphorylation levels of two MAPKs. Bcgbl1 is also involved in cell wall integrity, oxidative stress tolerance, and gene expression. Three target genes encoding hydrophobic surface binding proteins contribute to the adhesion and virulence of B. cinerea.
Article
Multidisciplinary Sciences
Kevin J. Vogel, Mark R. Brown, Michael R. Strand
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Biochemistry & Molecular Biology
Adam J. Bewick, Kevin J. Vogel, Allen J. Moore, Robert J. Schmitz
MOLECULAR BIOLOGY AND EVOLUTION
(2017)
Article
Multidisciplinary Sciences
Kerri L. Coon, Luca Valzania, David A. McKinney, Kevin J. Vogel, Mark R. Brown, Michael R. Strand
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Infectious Diseases
Kevin J. Vogel, Luca Valzania, Kerri L. Coon, Mark R. Brown, Michael R. Strand
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Multidisciplinary Sciences
Luca Valzania, Kerri L. Coon, Kevin J. Vogel, Mark R. Brown, Michael R. Strand
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Animesh Dhara, Jai-Hoon Eum, Anne Robertson, Monika Gulia-Nuss, Kevin J. Vogel, Kevin D. Clark, Rolf Graf, Mark R. Brown, Michael R. Strand
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Kerri L. Coon, Kevin J. Vogel, Mark R. Brown, Michael R. Strand
Article
Biology
Kevin J. Vogel, Nancy A. Moran
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2011)
Article
Entomology
LL Stelinski, KJ Vogel, LJ Gut, JR Miller
ENVIRONMENTAL ENTOMOLOGY
(2005)
Article
Entomology
LL Stelinski, LJ Gut, KJ Vogel, JR Miller
JOURNAL OF INSECT BEHAVIOR
(2004)