Article
Multidisciplinary Sciences
Robert S. Banh, Esther S. Kim, Quentin Spillier, Douglas E. Biancur, Keisuke Yamamoto, Albert S. W. Sohn, Guangbin Shi, Drew R. Jones, Alec C. Kimmelman, Michael E. Pacold
Summary: The study reveals a previously unknown protein HPDL's involvement in the biosynthesis of CoQ10, providing crucial insights into diseases related to HPDL deficiencies and cancers with HPDL overexpression.
Review
Biochemistry & Molecular Biology
Placido Navas, Maria Cascajo, Maria Alcazar-Fabra, Juan D. Hernandez-Camacho, Ana Sanchez-Cuesta, Ana Belen Cortes Rodriguez, Manuel Ballesteros-Simarro, Antonio Arroyo-Luque, Juan Carlos Rodriguez-Aguilera, Daniel J. M. Fernandez-Ayala, Gloria Brea-Calvo, Guillermo Lopez-Lluch, Carlos Santos-Ocana
Summary: Coenzyme Q(10) (CoQ(10)) deficiency is a rare disease primarily caused by mutations in COQ genes leading to defects in the synthesis machinery, while mutations in genes not directly related to synthesis can cause secondary deficiency. CoQ(10) deficiency can be successfully treated with CoQ(10) supplementation, but secondary deficiency cases may be underestimated.
Article
Biochemistry & Molecular Biology
Zuowei Pei, Liang Ma, Yawen Li, Jin Yang, Qin Yang, Wei Yao, Shijun Li
Summary: This study found that coenzyme Q10 could reduce cardiac damage, oxidative stress, and myocardial fibrosis levels in mice with doxorubicin-induced heart failure. It also exerted anti-apoptotic effects in heart failure mice.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Multidisciplinary Sciences
Ioannis Kipouros, Agnieszka Stanczak, Jake W. Ginsbach, Prokopis C. Andrikopoulos, Lubomir Rulsek, Edward I. Solomon
Summary: Melanins are important biopolymer pigments that provide photoprotection, and their biosynthesis involves the catalytic role of tyrosinase (Ty). This study combines spectroscopic, kinetic, and computational methods to investigate the mechanism of the rate-limiting step in melanin biosynthesis. The results provide insights into the O-2 activation and reactivity by the active sites of coupled binuclear copper, with implications in biocatalysis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Carmine Staiano, Laura Garcia-Corzo, David Mantle, Nadia Turton, Lauren E. Millichap, Gloria Brea-Calvo, Iain Hargreaves
Summary: Coenzyme Q (CoQ or CoQ(10)) was initially believed to be important only for mitochondrial respiratory chain, but recent studies show its essential role in various redox processes within different cellular membrane types. Endogenous CoQ biosynthesis is crucial for cellular function, and defects in this pathway lead to primary CoQ deficiencies, characterized by decreased tissue CoQ levels and subsequent functional defects. Secondary CoQ deficiencies can also arise from various cellular dysfunctions unrelated to biosynthesis. This article reviews the current understanding of CoQ biosynthesis, the defects causing diminished CoQ(10) levels in human tissues, and their clinical manifestations.
Article
Biochemistry & Molecular Biology
Karolina Dominiak, Wieslawa Jarmuszkiewicz
Summary: The relationship between mitochondrial production of reactive oxygen species (ROS) and mitochondrial energetics in different rat tissues is dependent on the content of the reduced coenzyme Q pool. Variation in the size of the reduced Q pool in different tissues may reflect diverse levels of ROS production and antioxidant demands. The existence of tissue-specific maximum respiratory chain capacity in ROS production and a proposed new parameter RCRROS highlights the potential control of oxidative phosphorylation through membrane potential.
Article
Biotechnology & Applied Microbiology
Chaoping Yue, Zhiwei Su, Baoyan Tai, Hui Tang, Wangbao Da, Hongli Xu, Huawei Zeng, Bingyue Xin, Xin Zeng
Summary: This study found that a proper dose of intracellular ROS (about 3.3 μmol H2O2/g DCW) could induce physiological modifications to promote the production of epsilon-PL. The proper dose of ROS activated the metabolism of the pentose phosphate pathway and promoted the biosynthesis of epsilon-PL and lysine. Additionally, energy provision was ensured by the activated metabolism of the TCA cycle. These findings have theoretical and practical significance for industrial production of epsilon-PL.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patrik Palacka, Jarmila Kucharska, Jana Obertova, Katarina Rejlekova, Jan Slopovsky, Michal Mego, Daniela Svetlovska, Boris Kollarik, Jozef Mardiak, Anna Gvozdjakova
Summary: Oxidative stress plays a significant role in cancer pathogenesis, and the level of thiobarbituric acid-reactive substances (TBARS)-a parameter of lipid peroxidation-has prognostic significance in chemotherapy-naive patients with metastatic urothelial carcinoma (mUC). The effect of cisplatin-based chemotherapy on oxidative stress, coenzyme Q(10), and antioxidants is still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Cheng-Han Lee, Ming-Sheng Lee, Rei-Cheng Yang, Chien-Sheng Hsu, Tzu-Cheng Su, Po-Sheng Chang, Ping-Ting Lin, Jun-Kai Kao
Summary: This study investigated the effects of exogenous CoQ10 on neonatal rats exposed to high oxygen levels. The results showed that CoQ10 increased the concentration of CoQ10 in the blood and mitigated the adverse effects of hyperoxia on the organs. However, it had no effect on inflammation, organ damage, or mortality. Further research is needed to determine the potential use of CoQ10 as an adjuvant therapy for neonatal hyperoxia.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karolina Dominiak, Lukasz Galganski, Adrianna Budzinska, Andrzej Woyda-Ploszczyca, Jerzy A. Zoladz, Wieslawa Jarmuszkiewicz
Summary: This study investigated the effects of aerobic exercise on coenzyme Q content and reactive oxygen species formation in the heart, liver and brain of rats. The results showed that aerobic exercise increased mitochondrial biogenesis and the level of reduced coenzyme Q in the heart and brain, acting as an antioxidant. Furthermore, aerobic exercise increased the antioxidant pool in the mitochondria of the heart and liver, but not in the brain. These findings suggest that aerobic exercise plays an important role in energy metabolism, redox homeostasis and oxidative stress levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Havza Imtiaz, Yamshi Arif, Pravej Alam, Shamsul Hayat
Summary: Apocarotenoids are essential metabolites found in all organisms. They have diverse functions and are derived from carotenoids through enzymatic or non-enzymatic reactions. Apocarotenoids play crucial roles in plant growth, development, and response to environmental stimuli, as well as mediating interactions with other organisms.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Plant Sciences
Hui Song, Feng Chen, Xi Wu, Min Hu, Qingliu Geng, Min Ye, Cheng Zhang, Li Jiang, Shuqing Cao
Summary: The MNB1 gene is involved in regulating the response to Fe-deficiency stress in Arabidopsis, affecting Fe accumulation and tolerance. It modulates reactive oxygen species levels and the ROS-mediated signaling pathway, thereby influencing the expression of Fe uptake- and translocation-related genes.
Article
Toxicology
Sarah Daniel, Danielle Phillippi, Leah J. Schneider, Kayla N. Nguyen, Julie Mirpuri, Amie K. Lund
Summary: Exposure to DEP results in persistent inflammation and bacterial alterations in the lungs, which are exacerbated by concurrent HF diet consumption. Probiotic treatment can reduce the expansion of Proteobacteria caused by DEP exposure.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
David Mantle, Robert A. Heaton, Iain P. Hargreaves
Summary: Coenzyme Q10 plays crucial roles in the immune system as an electron carrier, antioxidant, and anti-inflammatory agent. It also functions within lysosomes, improving immune system function.
Article
Oncology
Yan-Jiun Huang, Alexander T. H. Wu, Hung-Yi Chiou, Ming-Tsang Chuang, Tzu-Ching Meng, Li-Nien Chien, Yun Yen
Article
Medicine, General & Internal
Cheng-Huang Shen, Hung-Yi Chiou, Min-Che Tung, Chia-Chang Wu, Wei-Tang Kao, Yuan-Hung Wang, Guang-Dar Juang
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2017)
Article
Neurosciences
Sung-Chun Tang, Kai-Chien Yang, Chaur-Jong Hu, Hung-Yi Chiou, Chau Chung Wu, Jiann-Shing Jeng
NEUROMOLECULAR MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
Yih-Ru Chen, Fang- Hsieh, Chi-Ching Chang, Nai-Fang Chi, Hsin-Chiao Wu, Hung-Yi Chiou
AMERICAN JOURNAL OF CARDIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Yu-Ning Chien, Ping-Ling Chen, Yi-Hua Chen, Hsiu-Ju Chang, Suh-Ching Yang, Yi Chun Chen, Hung-Yi Chiou
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2018)
Editorial Material
Public, Environmental & Occupational Health
Wayne Gao, Mattia Sanna, Li-Ling Huang, Ya-Wen Chiu, Yi-Hua Chen, Hung-Yi Chiou
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2018)
Article
Rehabilitation
Feng-Hang Chang, Pengsheng Ni, Hung-Yi Chiou, Wen-Hsuan Hou, Alan M. Jette
DISABILITY AND REHABILITATION
(2019)
Article
Environmental Sciences
Wen-Ta Li, Hui-Wen Chang, Meng-Hsien Chen, Hue-Ying Chiou, Bang-Yeh Liou, Victor Fei Pang, Wei-Cheng Yang, Chian-Ren Jeng
ENVIRONMENTAL POLLUTION
(2018)
Article
Multidisciplinary Sciences
Tian-Jong Chang, Cai-Mei Zheng, Mei-Yi Wu, Tzu-Ting Chen, Yun-Chun Wu, Yi-Lien Wu, Hsin-Ting Lin, Jing-Quan Zheng, Nain-Feng Chu, Yu-Me Lin, Sui-Lung Su, Kuo-Cheng Lu, Jin-Shuen Chen, Fung-Chang Sung, Chien-Te Lee, Yu Yang, Shang-Jyh Hwang, Ming-Cheng Wang, Yung-Ho Hsu, Hung-Yi Chiou, Senyeong Kao, Yuh-Feng Lin
SCIENTIFIC REPORTS
(2018)
Article
Health Care Sciences & Services
Po-Ya Chang, Li-Nien Chien, Chyi-Huey Bai, Yuh-Feng Lin, Hung-Yi Chiou
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2018)
Article
Infectious Diseases
Shu-Chen Kuo, Byron Fan, Hongye Zhu, Meng-Hsuan Wu, Fang-Jing Lee, Yu-Chieh Cheng, Hsiao-Yu Wu, Ya-Ting Hsu, Chao A. Hsiung, Shiow-Ing Wu, Wei J. Chen, Hung-Yi Chiou, Huey-Kang Sytwu, Hsiao-Hui Tsou
Summary: This modeling study examines the effectiveness of different screening strategies, contact tracing, and the severity of novel epidemic outbreaks for various population sizes. The study finds that universal testing has limited impact on reducing COVID-19 cases when rigorous contact tracing and symptomatic screening are implemented. However, contact tracing and symptomatic screening are effective in reducing cases by identifying subclinical cases.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Integrative & Complementary Medicine
Cheng-Jeng Tai, Yeu-Ching Shi, Chen-Jei Tai, Li-Jen Kuo, Ray-Jade Chen, Yu-Jia Chang, Ching Tzao, Chih-Hsiung Wu, Chun-Chao Chang, Hung-Yi Chiou, Ching-Hua Su
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2020)
Review
Ophthalmology
Hsin-Ming Liu, Chyi-Huey Bai, Cher-Ming Liou, Hung-Yi Chiou, Chiehfeng Chen
CURRENT EYE RESEARCH
(2018)
Article
Oncology
Yi-Chen Hsieh, Shih-Hsin Tu, Chien-Tien Su, Er-Chieh Cho, Chih-Hsiung Wu, Mao-Chih Hsieh, Shiyng-Yu Lin, Yun-Ru Liu, Chin-Sheng Hung, Hung-Yi Chiou
BREAST CANCER RESEARCH AND TREATMENT
(2017)
Article
Cell Biology
Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng, Hung-Yi Chiou
JOURNAL OF BIOMEDICAL SCIENCE
(2017)
Article
Genetics & Heredity
Katerina S. Kucera, Beth Lincoln Boyea, Brooke Migliore, Sarah Nelson Potter, Veronica R. Robles, Oksana Kutsa, Heidi Cope, Katherine C. Okoniewski, Anne Wheeler, Catherine W. Rehder, Edward C. Smith, Holly L. Peay
Summary: Screening for elevated CK-MM levels in dried blood spots is a feasible method to identify newborns with DMD. Including specific cutoffs, repeat testing, and genetic sequencing can improve the accuracy and sensitivity of screening.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Madeline Currey, Ilana Solomon, Sarah Mcgraw, Jenny Shen, Francisco Munoz, Ernesto Sosa, Vanessa Puello-Lozano, Sam Wing, Lisa Lopez, Michelle Afkhami, Janine Lobello, Szabolcs Szelinger, Stacy W. Gray
Summary: This study conducted qualitative interviews with cancer patients and providers to identify gaps in clinical care and propose care delivery solutions for the return of secondary germline findings. The responses of patients varied depending on the amount of pre-test counseling they received, and providers identified insufficient clinic time as a major barrier to pretest education. Online support tools and standardized pre-test education models were favored by providers. There were differing perspectives on how pre-test education should be integrated into clinical workflows, but agreement on the inclusion of differences between somatic and germline testing, likelihood of medically actionable findings, and the possibility of being referred to a genetics provider.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Kiely N. James, Shimul Chowdhury, Yan Ding, Sergey Batalov, Kelly Watkins, Yong Hyun Kwon, Lucitia Van Der Kraan, Katarzyna Ellsworth, Stephen F. Kingsmore, Lucia Guidugli
Summary: This study used genome sequencing to detect a wide range of copy-number variants (CNVs) and other non-single nucleotide variant/indel variant types. These genetic alterations accounted for 15.8% of reported variants, with deletions being the most common type. The study also found that additional genetic tests were ordered in some cases, but failed to report the variants detected by genome sequencing.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Asem Berkalieva, Nicole R. Kelly, Ashley Fisher, Samuel F. Hohmann, Monisha Sebastin, Miranda Di Biase, Katherine E. Bonini, Priya Marathe, Jacqueline A. Odgis, Sabrina A. Suckiel, Michelle A. Ramos, Rosamond Rhodes, Noura S. Abul-Husn, John M. Greally, Carol R. Horowitz, Melissa P. Wasserstein, Eimear E. Kenny, Bruce D. Gelb, Bart S. Ferket
Summary: The study aims to understand the effects of returning diagnostic sequencing results on clinical actions and economic outcomes for pediatric patients with suspected genetic disorders. The results showed that patients with positive findings were more likely to receive specialist consultation, but there were no significant increases in overall physician services and costs. More large-scale studies are needed to confirm these findings.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Kirstine Stochholm, Camilla Holmgard, Shanlee M. Davis, Claus H. Gravholt, Agnethe Berglund
Summary: This study assessed the incidence, prevalence, and age at diagnosis of individuals with 45,X/46,XY mosaicism and described the associated mortality pattern. The study found an increasing incidence of 45,X/46,XY mosaicism in males and a stable incidence in females. Males were diagnosed at an older age than females. Additionally, 45,X/46,XY mosaicism was associated with increased all-cause mortality.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Yunjia Chen, Ender Karaca, Nathaniel H. Robin, Dana Goodloe, Ali Al-Beshri, S. Joy Dean, Anna C. E. Hurst, Andrew J. Carroll, Fady M. Mikhail
Summary: This study confirms the association between DLG2 intragenic deletions and neurodevelopmental disorders, supports the haploinsufficiency of the DLG2 gene, and suggests a potential association between these deletions and congenital anomalies and dysmorphism.
GENETICS IN MEDICINE
(2024)