Article
Biology
Hong Shan, Xin Su, Tianhao Li, Yuqi Qin, Na Zhang, Liuyan Yang, Linsha Ma, Yun Bai, Lei Qi, Yunhui Liu, Qing-Tao Shen
Summary: The study describes high-resolution structures of the Nucleoprotein in two different oligomeric states and four different higher-order helical structures. The structural rearrangements required to transition between the different helical assemblies obtained are highlighted, providing a basis for the structural plasticity among different MuV nucleocapsids.
COMMUNICATIONS BIOLOGY
(2021)
Article
Virology
Anamarija Slovic, Tanja Kosutic-Gulija, Dubravko Forcic, Maja Santak, Maja Jagusic, Mirna Jurkovic, Dorotea Pali, Jelena Ivancic-Jelecki
Summary: Researchers successfully generated multiple recombinant mumps viruses using consensus sequences and different strategies, and observed variations during different passages. Characteristic substitutions were identified in the generation of recombinant viruses, and close monitoring of sub-consensus variability is necessary to prevent unwanted mutations.
Article
Virology
Mirna Jurkovic, Anamarija Slovic, Dubravko Forcic, Jelena Ivancic-Jelecki, Tanja Kosutic-Gulija, Maja Jagusic
Summary: The frequent mumps outbreaks in vaccinated populations and the occurrence of neurological complications indicate the need for more efficient vaccines and specific antiviral therapies. Ribavirin has been shown to induce mutations in the mumps virus genome without developing resistance in long-term exposure.
Article
Food Science & Technology
Tadanobu Takahashi, Yuuki Kurebayashi, Kazumasa Tani, Mika Yamazaki, Akira Minami, Hideyuki Takeuchi
Summary: Research has shown that catechins, especially epigallocatechin gallate (EGCG), possess antiviral effects against mumps virus infection. Unlike influenza viruses, catechins inhibit viral fusion activity rather than receptor binding and sialidase activities in mumps virus. This suggests that catechins could be a valuable food-derived antiviral agent against mumps virus.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Microbiology
Fumihiro Kato, Yuichiro Nakatsu, Keiko Murano, Aika Wakata, Toru Kubota, Takayuki Hishiki, Toshiyuki Yamaji, Minoru Kidokoro, Hiroshi Katoh, Makoto Takeda
Summary: Efforts to discover antiviral drug candidates against the mumps virus (MuV) continue, with a recent study showing that the retinoid acid receptor agonist CD437 exhibits anti-MuV activity by targeting a late step in the virus's life cycle. CD437 also inhibits replication of other paramyxoviruses and does not require induction of the retinoic acid-inducible gene (RIG)-I for its antiviral activity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Megumi Hara, Rie Koshida, Takashi Nakano
Summary: The study found that the mumps vaccination rate was 55.6%, with the most common reason for parents not vaccinating their children being that it is not a routine vaccine. Factors influencing mumps vaccination among parents included knowledge of adverse reaction types, sources of vaccination recommendations, reading vaccination guidelines, previous experience with other voluntary vaccines or gastroenteritis treatment, and having a deep understanding of vaccination.
Review
Biochemistry & Molecular Biology
Angel Bottini, Diana R. D. C. G. Pacheco, Fabio L. Forti, Nunzio Bottini
Summary: Vaccinia virus is a poxvirus used for smallpox vaccine development. Despite smallpox being declared eradicated, it still poses a bioterrorism threat. The importance of exploring druggable targets for poxvirus infections is highlighted by recent monkeypox outbreaks. VH1 phosphatase, a dual specificity phosphatase, is an ideal candidate for anti-poxvirus agent discovery due to its conservation within the poxviridae family and significant divergence from its human ortholog VHR phosphatase.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Review
Virology
Marie Kubota, Takao Hashiguchi
Summary: The mumps virus is an important human pathogen causing various diseases, with sporadic outbreaks occurring even in highly vaccinated populations. It not only causes systemic infection but also has specific tropism to glandular tissues and the central nervous system. The understanding of viral tropism involves various factors such as viral entry, host factor interactions, and host-cell immune responses.
Article
Biochemistry & Molecular Biology
Xiaojie Zhang, Sindhuja Sridhran, Levgeniia Zagoriy, Christina Eugster Oegema, Cyan Ching, Tim Pflaesterer, Herman K. H. Fung, Isabelle Becher, Ina Poser, Christoph W. Mueller, Anthony A. Hyman, Mikhil M. Savilski, Julia Mahamid
Summary: Researchers have discovered that cellular stress can disrupt the equilibrium of persistent infection and induce replication of the mumps virus. They found that persistent viral replication factories are dynamic condensates and identified the viral phosphoprotein as a key driver in their assembly. Under stress, phosphorylation of the phosphoprotein at its interaction interface with the viral polymerase increases, leading to the formation of a stable replication complex. By obtaining atomic models for the authentic mumps virus nucleocapsid, the researchers elucidated a concomitant conformational change that exposes the viral genome to its replication machinery. These events represent a stress-mediated switch within viral condensates that support increased viral replication.
Review
Virology
Jasmine Rae Frost, Saba Shaikh, Alberto Severini
Summary: Several studies have examined amino acid variations between circulating wild-type mumps strains and vaccine strains, focusing on the HN and F mumps surface glycoproteins. These variations may have potential effects on viral infection and immune responses.
Article
Virology
Monika Bajorek, Marie Galloux, Charles-Adrien Richard, Or Szekely, Rina Rosenzweig, Christina Sizun, Jean-Francois Eleouet
Summary: This study investigates the interaction between the matrix (M) and phosphoprotein (P) during respiratory syncytial virus (RSV) assembly and budding, revealing a direct interaction between M and P and identifying novel interaction sites on P. The findings highlight the importance of the tetrameric structural organization of P and the oligomerization domain (OD) for virus-like filament formation and VLP release.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Aika Wakata, Hiroshi Katoh, Fumihiro Kato, Makoto Takeda
Summary: The nucleolus is an important organelle involved in cellular stress responses, cell proliferation, and ribosome biosynthesis. In this study, the researchers investigated the association between mumps virus (MuV) infection and the nucleolus. They found that suppressing the expression of a nucleolar factor called Treacle reduced the proliferative potential of MuV and impaired the production of infectious virus particles. Furthermore, they discovered that MuV matrix protein (M) can interact with Treacle in the nucleolus. This study highlights the importance of the interaction between Treacle and M in the late stage of MuV infection.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Ravit Bassal, Tamy Shohat, Tal Levin, Rakefet Pando, Eilat Shinar, Doron Amichay, Mira Barak, Anat Ben-Dor, Adina Bar-Haim, Ella Mendelson, Dani Cohen, Lital Keinan-Boker, Victoria Indenbaum
Summary: This study assessed the sero-prevalence of mumps and rubella in Israel, finding that the population is sufficiently protected against rubella but not mumps. Sero-negativity for mumps was associated with age, highlighting the importance of vaccination at a young age.
Article
Virology
Maja Lang Balija, Adela Stimac, Tanja Kosutic Gulija, Andrea Gudan Kurilj, Ana Bekavac, Ante Plecas, Beata Halassy, Maja Jagusic, Dubravko Forcic
Summary: Mumps is a highly contagious viral disease that can be prevented by vaccination. However, recent outbreaks in highly vaccinated populations have raised concerns about vaccine effectiveness. In this study, researchers discovered that guinea pigs can be infected with the mumps virus and serve as a promising model for studying the immune response and pathogenesis of the virus. These findings have important implications for further research on MuV and potential vaccine development and testing.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Iga Dalidowska, Anna Orlowska, Marcin Smreczak, Pawel Bieganowski
Summary: The replication of Mononegavirales viruses relies on the chaperone activity of Hsp90, with a specific interaction between L and P proteins being necessary for functional viral polymerase. Interestingly, rabies and vesicular stomatitis virus L proteins can be expressed independently of P protein presence and in the presence of Hsp90 inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)