期刊
GENETICS IN MEDICINE
卷 10, 期 6, 页码 369-384出版社
SPRINGERNATURE
DOI: 10.1097/GIM.0b013e3181770196
关键词
GSTM1; CYP1A1; oral and pharyngeal cancers; epidemiology; meta-analysis and pooled analysis
资金
- NATIONAL CANCER INSTITUTE [P50CA097190, Z01CP010121, F32CA073173] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [KL2RR024154] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [Z01AI000732] Funding Source: NIH RePORTER
- NCI NIH HHS [F32 CA073173, P50CA097190, 5P50CA097190, P50 CA097190] Funding Source: Medline
- NCRR NIH HHS [KL2 RR024154, 1KL2 RR024154-02] Funding Source: Medline
The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 (or) ([infi]m2m2): 1.3 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. bur findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.
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