期刊
GENETICS
卷 192, 期 3, 页码 1095-+出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.112.144477
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资金
- National Institutes of Health [GM74768]
During the development of female mammals, one of the two X chromosomes is inactivated, serving as a dosage-compensation mechanism to equalize the expression of X-linked genes in females and males. While the choice of which X chromosome to inactivate is normally random, X chromosome inactivation can be skewed in F1 hybrid mice, as determined by alleles at the X chromosome controlling element (Xce), a locus defined genetically by Cattanach over 40 years ago. Four Xce alleles have been defined in inbred mice in order of the tendency of the X chromosome to remain active: Xce(a)
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