期刊
GENETICS
卷 185, 期 4, 页码 1345-1354出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.110.115030
关键词
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资金
- Engineering and Physical Sciences Research Council [EP/H003851/1]
- Burroughs Wellcome Fund
- David and Lucile Packard Foundation
- James S. McDonnell Foundation
- Alfred P. Sloan Foundation
- Engineering and Physical Sciences Research Council [EP/H003851/1] Funding Source: researchfish
- EPSRC [EP/H003851/1] Funding Source: UKRI
Much of population genetics is based on the diffusion limit of the Wright-Fisher model, which assumes a fixed population size. This assumption is violated in most natural populations, particularly for microbes. Here we study a more realistic model that decouples birth and death events and allows for a stochastically varying population size. Under this model, classical quantities such as the probability of and time before fixation of a mutant allele can differ dramatically from their Wright-Fisher expectations. Moreover, inferences about natural selection based on Wright-Fisher assumptions can yield erroneous and even contradictory conclusions: at small population densities one allele will appear superior, whereas at large densities the other allele will dominate. Consequently, competition assays in laboratory conditions may not reflect the outcome of long-term evolution in the field. These results highlight the importance of incorporating demographic stochasticity into basic models of population genetics.
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