期刊
GENETICS
卷 185, 期 1, 页码 55-U104出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.110.115139
关键词
-
资金
- National Science Foundation [NSF-MCB0718384]
- National Institutes of Health [GM62207]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0718384] Funding Source: National Science Foundation
The condensin complex is a key determinant of higher-ordered chromosome structure. We show here that the complex is also important for the correct alignment of chromosomes on the meiosis I spindle. Unlike during mitosis and meiosis II, when sister chromatids attach to microtubules emanating from opposite spindle poles (biorientation), accurate meiosis I chromosome segregation requires that sister chromatids attach to microtubules emanating from the same spindle pole (coorientation). The monopolin complex, consisting of Lrs4, Csm1, and the meiosis-specific component Mam1, brings about meiosis I coorientation. We find that in the absence of functional condensin complexes, a fraction of sister kinetochores biorient on the meiosis I spindle and association of the monopolin complex subunit Mam1 with kinetochores is decreased. Our studies uncover a new locus-specific effect of the condensin complex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据