Article
Biology
Jack G. Rayner, Thomas J. Hitchcock, Nathan W. Bailey
Summary: Recent research suggests that dosage compensation on the X chromosome scales phenotypic effects between the sexes, with incomplete dosage compensation potentially leading to female-biased effects on X-linked alleles.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Takahiro Fukui, Takashi Kiuchi, Kenta Tomihara, Tomohiro Muro, Noriko Matsuda-Imai, Susumu Katsuma
Summary: Wolbachia, an intracellular bacteria in insects, can manipulate sexual development and reproduction. A recently identified protein, Oscar, interacts with the Masc protein and interferes with dosage compensation, leading to male killing in lepidopteran insects.
Article
Genetics & Heredity
William Jordan, Erica Larschan
Summary: In this study, it was demonstrated that CLAMP promotes the three-dimensional clustering of MSLc binding sites. Additionally, the X-enriched CLAMP protein was found to promote longer-range three-dimensional interactions on the X-chromosome more strongly than on autosomes. Genome-wide, CLAMP is shown to facilitate three-dimensional interactions between active chromatin regions along with other insulator proteins.
EPIGENETICS & CHROMATIN
(2021)
Article
Plant Sciences
Takahiro Tezuka, Naoto Kitamura, Sae Imagawa, Akira Hasegawa, Kumpei Shiragaki, Hai He, Masanori Yanase, Yoshiyuki Ogata, Toshinobu Morikawa, Shuji Yokoi
Summary: Hybrid lethality, a postzygotic mechanism of reproductive isolation, is caused by epistatic interaction of genes and can lead to death of F-1 hybrid seedlings. In Nicotiana genus, HLA1 locus causing hybrid lethality was mapped between two DNA markers, with a 682 kb interval in the genome sequence of N. benthamiana.
Article
Biology
Michail Rovatsos, Tony Gamble, Stuart Nielsen, Arthur Georges, Tariq Ezaz, Lukas Kratochvil
Summary: Research has shown that despite the evolution of male heterogamety in certain gecko species, gene expression imbalance still exists. This suggests that gene dosage regulatory mechanisms may be related to the general mechanisms of sex determination rather than the type of sex chromosome heterogamety.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Microbiology
Cintya del Rio E. Hernandez, Lani J. Campbell, Paul H. Atkinson, Andrew B. Munkacsi
Summary: Many approved drugs, such as statins, have multiple effects and interact with poorly understood genetic networks. Using the yeast genetic model, this study investigated genetic interactions in two statin-resistant genetic backgrounds, identifying genes related to dysregulated endocytosis and autophagic cell death. The findings may provide potential drug targets for cancer treatment.
MICROBIOLOGY SPECTRUM
(2023)
Article
Endocrinology & Metabolism
Hongyi Yang, Yan Liu, Wenbin Niu, Zilan Yang, Yang Wang, Haixia Jin, Gang Li
Summary: This study aimed to evaluate the influence of abnormal semen parameters on embryo aneuploidy using a single nucleotide polymorphism microarray (SNP array). The results showed that abnormal semen parameters may affect embryo quality and increase the rate of aneuploidy in blastocyst chromosomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Arielle S. Fogel, Emily M. McLean, Jacob B. Gordon, Elizabeth A. Archie, Jenny Tung, Susan C. Alberts
Summary: Genetic ancestry is a consistent predictor of opposite-sex affiliative behavior in baboons, with increased anubis genetic ancestry associated with a higher probability of such behavior. Furthermore, pairs of anubis-like males and anubis-like females were more likely to socially affiliate, suggesting that affiliative behavior may promote and constrain baboon admixture through genetic effects.
Article
Computer Science, Information Systems
Andrea Brunello, Dario Della Monica, Angelo Montanari, Nicola Saccomanno, Andrea Urgolo
Summary: In many domains, continuous streams of data are generated by systems during their execution, which include valuable telemetry information. Deep learning models have been increasingly successful in utilizing this data for tasks like preemptive failure detection. However, these models lack guarantees over their execution and interpretability, which is problematic in critical contexts. To address these challenges, we propose a framework that combines monitoring, a lightweight runtime verification technique, with machine learning to automatically derive relevant properties and anticipate critical system behaviors in an online setting using Signal Temporal Logic formulas.
Article
Agriculture, Dairy & Animal Science
Fereshte Kaviani, Mohsen Gholizadeh, Hasan Hafezian
Summary: The objective of this study was to investigate the genetic inheritance of growth traits in Mazandaran native chickens by assessing autosomal and sex-linked genetic effects. It was found that there was no significant sex-linked additive genetic effect on body weight at hatching (BW0), while for body weight at 8 weeks (BW8) and 12 weeks (BW12), a model including autosomal, sex-linked direct additive, and maternal effects without global dosage compensation on the Z chromosome was the most appropriate. The heritability estimates for autosomal effects were relatively low, while the estimates for sex-linked effects were higher, particularly for BW12. There were positive genetic correlations among all traits, and a high genetic correlation between BW8 and BW12 due to sex-linked effects. Maternal genetic correlations were also observed between different body weight traits.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Genetics & Heredity
Jun Ren, Yuezhi Keqie, Yutong Li, Lingping Li, Min Luo, Meng Gao, Cuiting Peng, Han Chen, Ting Hu, Xinlian Chen, Shanling Liu
Summary: Chromosome rearrangement is a major cause of abortion, especially in individuals with double chromosomal rearrangements. We conducted preimplantation genetic testing for structural rearrangement (PGT-SR) on a couple with recurrent abortion and found a cryptic balanced chromosomal rearrangement in the male. Optical genome mapping (OGM) was performed to confirm the results, which showed consistency with the previous PGT findings. Compared to traditional methods like karyotyping, chromosomal microarray, CNV-seq, and FISH, OGM has significant advantages in detecting cryptic and balanced chromosomal rearrangements.
FRONTIERS IN GENETICS
(2023)
Article
Polymer Science
Aggelos Koutsomichalis, Thomas Kalampoukas, Dionysios E. Mouzakis
Summary: The study aimed to manufacture hybrid composites with superior ballistic performance and analyze their viscoelastic and mechanical response. Various composites were manufactured from different fabrics and analyzed through static bending and dynamic mechanical analysis. The study also proposed a new mathematical function for high accuracy in time-temperature superposition analysis.
Article
Engineering, Environmental
Yue Dong, Jun Niu, Qi Liu, Bellie Sivakumar, Taisheng Du
Summary: A hybrid model using support vector machine and genetic programming was proposed for wind speed prediction, with error compensation for residuals. Experimental results showed the efficiency and accuracy of the method in predicting wind speed.
STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT
(2021)
Article
Medicine, General & Internal
Xian-hua Lin, Meng-xi Guo, Dan-dan Wu, Yao Lu, Jian-lin Zhang, Cheng-liang Zhou, Li Jin, Li Wang, Chen Zhang, Chen-ming Xu, Song-chang Chen, Song-ying Zhang, Xiao-xi Sun, Yan-ting Wu, Yun Sun, He-feng Huang
Summary: This study aims to compare the effects of conventional ICSI and ICSI+PGT-A in couples with severe male infertility. A randomized controlled trial including 188 participants in each group will investigate live birth rate and other reproductive outcomes as primary and secondary outcomes.
Article
Andrology
Ying-Hua Wang, Meng Yan, Xi Zhang, Xin-Yu Liu, Yi-Fu Ding, Chong-Ping Lai, Ming-Han Tong, Jin-Song Li
Summary: This study successfully corrected a single gene mutation carried by azoospermia patients, enabling them to have fertile offspring. Repaired spermatogonial stem cells could restore spermatogenesis in infertile males, providing a new approach for treating male azoospermia.
ASIAN JOURNAL OF ANDROLOGY
(2021)
