Article
Genetics & Heredity
Andrea Sevcovicova, Jana Plava, Matej Gazdarica, Eva Szabova, Barbora Huraiova, Katarina Gaplovska-Kysela, Ingrid Cipakova, Lubos Cipak, Juraj Gregan
Summary: The study revealed that phosphorylation sites on the Swi5-Sfr1 complex contribute to its partially functional state during meiosis, but the functional relevance of this phosphorylation remains to be determined.
Article
Genetics & Heredity
Reine U. Protacio, Mari K. Davidson, Wayne P. Wahls
Summary: Meiosis is a crucial process in the sexual life cycle of eukaryotes, contributing to genetic diversity through independent chromosome assortment and meiotic recombination. Recent studies have shown significant changes in the frequency distribution of recombination between closely related species, subspecies, and isolated populations of the same species. Analysis of recombination plasticity in fission yeast has provided new insights into the mechanisms underlying these rapid evolutionary changes, with different classes of hotspots acting as independently controlled rheostats. This dynamic modulation can rapidly and dramatically alter the global frequency distribution of recombination, contributing to the evolutionarily rapid changes in the recombination landscape.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Kim Kiat Lim, Hwei Yee Teo, Yuan Yee Tan, Yi Bing Zeng, Ulysses Tsz Fung Lam, Mahesh Choolani, Ee Sin Chen
Summary: MTHFR is a key enzyme in the folate metabolic pathway, linked to various human conditions. The fission yeast gene met11(+) shows similar function to MTHFR, affecting chromosome stability and meiotic fidelity. Cooperation among Met11, Rec8, and Sgo1 is crucial for proper genetic inheritance during mitosis and meiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yu Ono, Kenta Katayama, Tomoki Onuma, Kento Kubo, Hayato Tsuyuzaki, Michiaki Hamada, Masamitsu Sato
Summary: This study focuses on identifying functional non-coding RNAs (ncRNAs) in the fission yeast Schizosaccharomyces pombe through a combination of computational and biological screening. By screening for ncRNAs with conserved sequences and secondary structures, the researchers identified several novel functional ncRNAs, including one that inhibited untimely initiation of sexual differentiation. This study demonstrates the power of in silico selection based on conservation of secondary structures in identifying novel functional ncRNAs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biology
Emilio Gonzalez-Martin, Juan Jimenez, Victor A. Tallada
Summary: Cohesin, a ring-shaped protein complex, is highly conserved and found in all eukaryotes. It consists of SMC1, SMC3, and RAD21. Mutations in its components or regulators can lead to genetic syndromes and cancer. In this study, BiFCo is introduced as a versatile system that allows monitoring of complex assembly and disassembly in living cells, providing insights into dynamic chromatin loading and unloading.
LIFE SCIENCE ALLIANCE
(2023)
Article
Genetics & Heredity
R. Blake Billmyre, Michael T. Eickbush, Caroline J. Craig, Jeffrey J. Lange, Christopher Wood, Rachel M. Helston, Sarah E. Zanders
Summary: This study developed a high-throughput insertional mutagenesis approach to identify genes involved in sexual reproduction in fission yeast. They identified hundreds of novel genes contributing to sexual reproduction, including some that affect spore viability and others that are required for growth in low-density conditions. This research provides valuable insights into the genetic contributions to sexual reproduction and identifies potential candidate genes in other eukaryotes, including humans.
Article
Microbiology
Jeong Hwan Joo, Hyun Ah Kang, Keun Pil Kim, Soogil Hong
Summary: This study investigates the role of Pds5 in meiosis by conducting physical analysis and high-resolution microscopy analysis. The results demonstrate that Pds5 plays an important role in meiotic-specific recombination and chromosome morphogenesis by suppressing sister chromatid pairing and abnormal compaction of the chromosome axis.
JOURNAL OF MICROBIOLOGY
(2022)
Review
Cell Biology
Masamitsu Sato, Yasutaka Kakui, Mika Toya
Summary: Meiosis is a specialized cell division process for gamete production in eukaryotes, with chromosomes and microtubules mutually influencing each other. Studies on the fission yeast Schizosaccharomyces pombe have revealed the organization of chromosomes, cytoskeleton, and cell cycle progression in mitosis and meiosis. Meiosis is strategically designed for faithful genetic material segregation and genetic diversity production through meiosis-specific and general factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Alberto Pineda-Santaella, Nazaret Fernandez-Castillo, Alberto Jimenez-Martin, Maria del Carmen Macias-Cabeza, Angela Sanchez-Gomez, Alfonso Fernandez-Alvarez
Summary: Chromosome segregation in female meiosis in many metazoans is mediated by acentrosomal spindles, which self-assemble without the involvement of centrosomes. A recent study in fungi demonstrated the formation of self-assembled microtubule arrays capable of segregating chromosomes, shedding light on the molecular mechanisms behind acentrosomal meiosis. Comparing self-assembled spindles with canonical SPB-dependent spindles revealed both similarities and differences, with potential for further understanding gametogenesis.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Takahisa Maki, Genevieve Thon, Hiroshi Iwasaki
Summary: A haploid of the fission yeast Schizosaccharomyces pombe expresses either the P or M mating-type through gene conversion, which is determined by the active mat1 cassette. The Swi2-Swi5 complex plays a crucial role in this process by selecting a preferred donor in a cell-type specific manner. Two important motifs in Swi2, a Swi6-binding site and two DNA-binding AT-hooks, have been identified and shown to be essential for its localization to the recombination enhancers in order to promote gene conversion.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Cell Biology
Corinne Grey, Bernard de Massy
Summary: The axial element plays a crucial role in establishing sister chromatid cohesion and meiotic recombination during prophase I of meiosis, contributing to the successful outcome of meiosis I.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Wu Zuo, Guangming Chen, Zhimei Gao, Shuai Li, Yanyan Chen, Chenhui Huang, Juan Chen, Zhengjun Chen, Ming Lei, Qian Bian
Summary: During meiosis, chromosomes undergo significant changes in morphology and intranuclear positioning. A study using Hi-C mapping in mouse spermatogenesis revealed the roles of transcriptional activity and mechanical force in homolog alignment and recombination.
NATURE COMMUNICATIONS
(2021)
Review
Plant Sciences
Pablo Bolanos-Villegas
Summary: Cohesin, a crucial protein complex for cell division, plays a significant role in plant chromosome cohesion and genetic transmission. Understanding chromatid cohesion in plants can enhance the selection of desirable traits in commercial breeding. Research on chromatid cohesion offers opportunities for improving crop breeding outcomes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Mary Pickering, Mira Magner, Dan Keifenheim, Nicholas Rhind
Summary: This study demonstrates that the commitment to mitosis is regulated by CDK activity. Both Cdc13 and Cig2 cyclins in fission yeast are capable of driving mitosis, supporting the quantitative model of CDK function. This highlights the versatility of cyclins in regulating cell cycle processes.
Article
Microbiology
Marina Pascual-Ortiz, Eva Walla, Ursula Fleig, Adolfo Saiardi
Summary: This study investigated the regulation of polyP metabolism in yeast, revealing that different yeasts utilize different classes of IPPs to regulate polyP synthesis. While the mechanism of polyP synthesis is conserved in yeasts, the regulatory players are diverse.
Article
Chemistry, Multidisciplinary
Charles Guerin, Ludivine Jean-Gerard, Guillaume Octobre, Simon Pascal, Olivier Maury, Guillaume Pilet, Audrey Ledoux, Bruno Andrioletti
Article
Biochemistry & Molecular Biology
Jose Dias, Guillaume Octobre, Lydia Kobbi, Martine Comisso, Sebastian Flisiak, Marc Mirande
Article
Genetics & Heredity
Guillaume Octobre, Alexander Lorenz, Josef Loidl, Juerg Kohli
Article
Materials Science, Multidisciplinary
Ophelie I. Berthuy, Celine A. Mandon, Benjamin P. Corgier, Guillaume G. Octobre, Giacomo Ceccone, Valentina Spampinato, Loic J. Blum, Christophe A. Marquette
JOURNAL OF MATERIALS SCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Lydia Kobbi, Guillaume Octobre, Jose Dias, Martine Comisso, Marc Mirande
JOURNAL OF MOLECULAR BIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Vitaly Latypov, Maja Rothenberg, Alexander Lorenz, Guillaume Octobre, Ortansa Csutak, Elisabeth Lehmann, Josef Loidl, Juerg Kohli
MOLECULAR AND CELLULAR BIOLOGY
(2010)
Article
Biology
G Octobre, C Lemercier, S Khochbin, M Robert-Nicoud, C Souchier
COMPTES RENDUS BIOLOGIES
(2005)