期刊
GENETICS
卷 178, 期 1, 页码 273-281出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.107.080754
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060122] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM060122] Funding Source: Medline
Application of a high dose of juvenile hormone (JH) III or its mimics (JHM) to Drosophila at the white pupariurn stage causes the formation of a pupal-like abdomen with few or no short bristles. We report here that the rosy (ry) gene encoding the enzyme xanthine dehydrogenase (XDH), which catalyzes the filial two-step oxidation in purine catabolism, is required for this effect of JH on the epidermis. In ry(506) (null allele) homozygotes or hemizygotes,JH III or pyriproxifen (aJHM) had little effect on abdominal bristle or cuticle formation, but disrupted the development of the central nervous system as in wild-type flies. Wild-type ry rescued the JH sensitivity of the abdominal epidermis in ry(506) mutants. Inhibition of XDH activity phenocopied the ry null mutant's insensitivity to JH. Larvae fed on hypoxanthine or xanthine showed a decreased JH sensitivity ry(506) clones were sensitive to JH, indicating that ry is required non-cell autonomously for the JH effects. Normally JH applied at pupariation causes the aberrant reexpression of the transcription factor broad in the abdominal epidermis during adult development, but in the ry(506) mutant most of the cells in the dorsal tergite showed no broad reexpression, indicating that ry is upstream of broad in the JH signaling pathways.
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