期刊
GENETICS
卷 178, 期 3, 页码 1639-1652出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.107.084269
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资金
- ICREA Funding Source: Custom
Domestic species allow us to study dramatic evolutionary changes at an accelerated rate clue to the effectiveness of modern breeding techniques and the availability of breeds that have undergone distinct selection pressures. We present a worldwide survey of haplotype variability around a known causative mutation in porcine gene IGF2, which increases lean content. We genotyped 34 SNPs spanning 27 kb in 237 domestic pigs and 162 wild boars. Although the selective process had wiped out variability for at: least 27 kb in the haplotypes carrying the imitation, there was no indication of an overall reduction in genetic variability of international VS. European local breeds; there was also no evidence of a reduction in variability caused by domestication. The haplotype structure and a plot of Tajima's D against the frequency of the causative mutation across breeds suggested a temporal pattern, where each breed corresponded to a different, selective stage. This was observed comparing the haplotype neighbor joining (NJ) trees of breeds that have undergone increasing selection pressures for leanness, e.g., European local breeds vs. Pietrain. These results anticipate that comparing current domestic breeds will decisively help to recover the genetic history of domestication and contemporary selective processes.
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