Article
Environmental Sciences
Steven R. Parratt, Benjamin S. Walsh, Soeren Metelmann, Nicola White, Andri Manser, Amanda J. Bretman, Ary A. Hoffmann, Rhonda R. Snook, Tom A. R. Price
Summary: For 43 Drosophila species, global distributions better match male-sterilizing temperatures than lethal temperatures. This suggests that species distributions may be determined by thermal limits to reproduction, rather than survival, potentially underestimating the impacts of climate change for many organisms.
NATURE CLIMATE CHANGE
(2021)
Article
Biochemistry & Molecular Biology
Elodie Martin, Raheleh Heidari, Veronique Monnier, Herve Tricoire
Summary: Study found that partial nej/dCBP depletion in adult Drosophila glial cells can protect against mutant huntingtin-induced pathology, leading to increased lifespan and restored locomotor activity. This discovery reveals a contrasting impact of HD pathology in glial cells compared to neurons, suggesting that combinatorial approaches combined with specific tissue targeting may be key to identifying effective therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agronomy
Fang Li, Akihiko Yamamoto, Esther J. Belikoff, Amy Berger, Emily H. Griffith, Maxwell J. Scott
Summary: The study developed transgenic strains of D. suzukii with dominant conditional female lethal transgenes. When raised without tetracycline, female D. suzukii die. Laboratory cage trials show that releasing excess transgenic males can suppress D. suzukii populations.
PEST MANAGEMENT SCIENCE
(2021)
Review
Cell Biology
Przemyslaw Zakrzewski, Marta Lenartowska, Folma Buss
Summary: Spermiogenesis is the final stage of spermatogenesis, during which MYO6 plays crucial roles in regulating organelle delivery/segregation, forming testicular structures, and generating force and movement for sperm differentiation across various organisms.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Jennie Kline, Badri Vardarajan, Avinash Abhyankar, Sonja Kytomaa, Bruce Levin, Nara Sobreira, Andrew Tang, Amanda Thomas-Wilson, Ruiwei Zhang, Vaidehi Jobanputra
Summary: This study found that rare damaging genetic variants in the conceptus may be a cause of chromosomally normal pregnancy loss. The proportion of cases with harmful variants was higher, mainly occurring in genes that could potentially be embryonic lethal.
FERTILITY AND STERILITY
(2021)
Article
Multidisciplinary Sciences
Ben Ewen-Campen, Haojiang Luan, Jun Xua, Rohit Singh, Neha Joshi, Tanuj Thakkar, Bonnie Berger, Benjamin H. White, Norbert Perrimon
Summary: The split-Gal4 system based on a self-excising split-intein enables genetic labeling of specific cell types and tissues in Drosophila with temporal control. It can be repressed by Gal80 and can be combined with the drug-inducible GeneSwitch system for inducible control. In addition, the system can generate highly specific genetic drivers based on scRNAseq datasets and provides a plasmid toolkit for efficient driver creation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Yuta Seki, Hiroshi Shitara, Rie Ishii, Takafumi Ouchi, Shumpei P. Yasuda, Yoshiaki Kikkawa
Summary: The study found that MYO6 haploinsufficiency leads to progressive hearing loss in mice. Female +/- mice showed faster progression of hearing loss compared to male mice, with reduced outer hair cells and significantly decreased IHC ribbon synapses in the basal area of the cochlea in +/- mice.
Article
Biochemistry & Molecular Biology
Alexandru Al. Ecovoiu, Attila Cristian Ratiu, Miruna Mihaela Micheu, Mariana Carmen Chifiriuc
Summary: Drosophila melanogaster is a versatile model organism in genetics that has been used to study and simulate human genetic diseases. By transferring human genes into fruit flies and observing the effects, researchers can identify and validate genetic variants associated with human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Roshni R. Kharadi, Kayla Selbmann, George W. Sundin
Summary: The study revealed the essential regulatory role of Cyclic-di-GMP in bacteria, affecting biofilm formation and pathogenicity, with specific Dgc genes showing different regulatory effects on biofilm formation, type III secretion, and disease development.
Article
Agronomy
Ravi Koppolu, Guojing Jiang, Sara G. Milner, Quddoos H. Muqaddasi, Twan Rutten, Axel Himmelbach, Yu Guo, Nils Stein, Martin Mascher, Thorsten Schnurbusch
Summary: The spikelet indeterminacy and supernumerary spikelet phenotypes in the barley multiflorus2.b mutant exhibit polygenic inheritance. Major QTLs for these phenotypes were identified on chromosomes 2H and 6H. The co-location of QTLs for lateral spikelet indeterminacy and central spikelet supernumerary phenotypes suggests a potential regulation by a single genetic factor. Further research into the genes underlying these QTLs will contribute to understanding yield formation in small grain cereals.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Biology
Ben C. Tilly, Gillian E. Chalkley, Jan A. van der Knaap, Yuri M. Moshkin, Tsung Wai Kan, Dick H. W. Dekkers, Jeroen A. A. Demmers, C. Peter Verrijzer
Summary: This study used live-cell imaging of Drosophila polytene nuclei to show that only a small portion of BRM chromatin remodeler is bound to chromatin at any given time, with its binding affected by the local chromatin condensation. ATP hydrolysis plays a critical role in releasing BRM from chromatin and regulating histone turnover.
Article
Plant Sciences
Hui Yu, Qiushi Wang, Zhirui Zhang, Tao Wu, Xinjing Yang, Xiaobin Zhu, Yongheng Ye, Jiantian Leng, Suxin Yang, Xianzhong Feng
Summary: This study revealed the crucial role of the GmTic110a gene in chloroplast development, as its mutation resulted in decreased chlorophyll content and reduced chloroplast stroma thylakoids, ultimately affecting soybean yield.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Shudong Niu, Kaixin Cheng, Longzhong Jia, Jing Liang, Lu Mu, Yibo Wang, Xuebing Yang, Chen Yang, Yan Zhang, Chao Wang, Lijun Huang, Huarong Wang, Shuang Zhang, Hua Zhang
Summary: This study demonstrated that ovarian granulosa cell tumors (GCTs) originate from mutant granulosa cells (GCs) and identified the upregulation of immune evasion genes Cd24a and Cd47 as a mechanism for the transition of mutant GCs to GCTs. Treatment with the Cd47 inhibitor RRX-001 effectively suppressed GCT growth in vivo.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Plant Sciences
Jolly Chatterjee, Robert A. Coe, Kelvin Acebron, Vivek Thakur, Ragothaman M. Yennamalli, Florence Danila, Hsiang-Chun Lin, Christian Paolo Balahadia, Efren Bagunu, Preiya P. O. S. Padhma, Soumi Bala, Xiaojia Yin, Govinda Rizal, Jacqueline Dionora, Robert T. Furbank, Susanne von Caemmerer, William Paul Quick
Summary: The study identified a low CO2-responsive mutant Icr1 with a mutation in the beta-carbonic anhydrase (CA) gene, leading to reduced growth and photosynthesis. The mutated gene caused a decrease in CA protein activity and abundance, restricting the supply of bicarbonate to PEPC and ultimately limiting C-4 photosynthesis and growth. These findings highlight the importance of CA in the C-4 photosynthesis pathway and provide insights into potential targets for improving C-4 biochemical pathways in crops like rice.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Immunology
Zihao Deng, Yanyang Yang, Jiazhen Luo, Biling Zhang, Jiyong Liu, Guanghou Shui, Renjie Jiao, Chuanxian Wei
Summary: This study assessed the temporal changes of lipid metabolism profiles during infection using integrated transcriptomics and lipidomics analysis. It identified the importance of ergosterol in host defense against pathogens, with its level increased upon bacterial infection. The study also showed that increasing ergosterol level promotes host survival against bacterial challenges.
FRONTIERS IN IMMUNOLOGY
(2022)
