Article
Biochemistry & Molecular Biology
Petra Vande Zande, Patricia J. Wittkopp
Summary: This study uses expression and fitness data from Saccharomyces cerevisiae gene deletion strains to show that cis-acting mutations tend to have lower pleiotropy and trans-acting mutations are more deleterious. These findings provide strong support for the role of pleiotropy in the preferential fixation of cis-regulatory alleles over evolutionary time.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Chemistry, Multidisciplinary
Sunil K. Gupta, Shreya Banerjee, Erode N. Prabhakaran
Summary: This study discovers the presence of local van der Waals interactions at the cis amide bond in crystals of isobutyroyl-Pro-Val-OMe, and demonstrates that expanding this interaction volume leads to a corresponding sigmoidal increase in cis amide stabilization by up to -0.24 kcal mol(-1). These vdW interactions contribute 60% towards similar CH...pi interaction energies.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Christian J. Oswood, David W. C. MacMillan
Summary: Traditional approaches to stereoselective synthesis usually require high levels of control in forming new stereocenters. This study presents an alternative method where the stereochemistry of organic substrates is selectively edited without further structural modification, allowing access to rare or valuable stereochemical configurations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Marco Nazareno Dell'Anna, Mathew Laureano, Hamed Bateni, John E. Matthiesen, Ludovic Zaza, Michael P. Zembrzuski, Thomas J. Paskach, Jean-Philippe Tessonnier
Summary: The integration of microbial and electrochemical conversions in hybrid processes can enhance the productivity of t3HDA by over 50 times. The composition of the broth plays a crucial role in the subsequent electrochemical step, with neutral pH and high ccMA titer enhancing the electrochemical hydrogenation.
Article
Plant Sciences
Zsolt Gulyas, Blanka Moncsek, Kamiran Aron Hamow, Pal Straner, Zoltan Tolnai, Eszter Badics, Norbert Incze, Eva Darko, Valeria Nagy, Andras Perczel, Laszlo Kovacs, Vilmos Soos
Summary: This study characterizes D27-LIKE1 in Arabidopsis and highlights its important physiological and enzymatic functions related to carotenoids. The results show that D27-LIKE1 has multi-substrate specificity and may regulate carotenoid cis pools and the biosynthesis pathways of strigolactones and ABA.
Article
Chemistry, Physical
Ying Sun, Jialin Sun, Zhenming Yin
Summary: Two 2-(4-hydroxylphenyl)-azopyrrole compounds were synthesized and characterized. The properties of azopyrrole can be drastically tuned by slight changes in the substituent on the pyrrole N atom. Compound 1 self-assembled into a pillar structure through hydrogen bonds, while compound 2 formed a double-strand helical and tube structure. UV-Vis spectra studies showed that the cistrans conversion rate of compound 2 is solvent dependent, with protic and polar solvents promoting the conversion.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Multidisciplinary
Debajit Kalita, Biswajit Sahariah, Surya Pravo Mookerjee, Bani Kanta Sarma
Summary: Peptoids are peptide-like molecules with improved cell-permeability and proteolytic stability. However, the conformational flexibility of peptoids leads to moderate affinity towards biomacromolecules. Strategies involving the incorporation of specific side chains have been developed to control the cis-trans isomerization of peptoid amide bonds and design peptoid oligomers with well-defined secondary structures.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Physical
Jun Han, Qunfei Zheng, Cheng Jin, Shanmin Wang, Ying Liu, Yusheng Zhao, Jinlong Zhu
Summary: This study investigated the luminescence properties and structural changes of different stereoisomeric organic compounds under high pressure. The results showed that cis-stilbene did not undergo fluorescence enhancement due to pi-pi stacking, while trans-stilbene exhibited fluorescence enhancement at lower pressures. The study also found that cis-stilbene underwent an irreversible polymerization reaction, while trans-stilbene showed a more stable structure and could revert back to its original state after pressure release.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Isabella C. D. Merritt, Denis Jacquemin, Morgane Vacher
Summary: This study revisits the cis -> trans photo-isomerisation mechanism of azobenzene using high-level ab initio surface hopping mixed quantum-classical dynamics. Results show a reduction of photoisomerisation quantum yield on exciting to the higher energy pi pi* state compared to the lower energy n pi* state. The explanation for the decrease in quantum yield is found to be different from that observed in the trans -> cis photoisomerisation scenario.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Fredrick M. Mutunga, Kelly M. Olenyik, Aaron I. Strom, David T. Anderson
Summary: Through studying the diffusion and reactivity of hydrogen atoms in solid parahydrogen at low temperatures, it has been found that hydrogen atoms move through solid parahydrogen via quantum diffusion, influencing their reactivity. This phenomenon of inverse concentration dependence of the rate constant for the reaction step involving the hydrogen atom demonstrates clearly that quantum diffusion influences the reactivity of the hydrogen atoms in solid parahydrogen.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Organic
Hyune-Jea Lee, Yuya Yonekura, Nayoung Kim, Jun-ichi Yoshida, Heejin Kim
Summary: The rapid cis-trans isomerization of alpha-anionic stilbene was controllably achieved using flow microreactors, with reaction times precisely controlled within milliseconds to seconds at -50 degrees C to selectively yield the cis- or trans-isomer in high yields. This synthetic method in flow was successfully applied to synthesize precursors of commercial drug compound, (E)- and (Z)-tamoxifen, with high regioselectivity and productivity.
Article
Psychology, Multidisciplinary
Guruprasad Gadgil, Gayle Prybutok, Victor Prybutok
Summary: This study introduces a transgender privacy paradox impression management model to understand the impact of social networking site impression management on transgender users' sustained involvement in social networking, providing a new perspective in the field of information systems research. The results show that there is no direct relationship between privacy paradox and transgender individuals' online social media persona. However, transgender individuals use various impression management strategies on social media to maintain privacy and mediate the relationship between privacy paradox and their social media personas. The study also highlights the importance of social media presence for transgender individuals, as it is vital for their daily survival.
COMPUTERS IN HUMAN BEHAVIOR
(2023)
Review
Environmental Sciences
Willis Gwenzi, Jerikias Marumure, Zakio Makuvara, Tinoziva T. Simbanegavi, Emma Laureane Njomou-Ngounou, Esther Laurentine Nya, Korbinian Kaetzl, Chicgoua Noubactep, Piotr Rzymski
Summary: Pit latrines are widely promoted for sanitation improvement, but their pollution and health risks are often neglected. This review presents the paradox that pit latrines are both considered a sanitation technology to safeguard human health and pollution and health risk hotspots. Evidence shows that pit latrines serve as catch-all receptacles for hazardous waste disposal, including medical, pesticide, menstrual hygiene, and electronic wastes. Pit latrines receive, harbor, and transmit conventional and emerging contaminants, as well as bacterial and viral pathogens and disease vectors. They also contribute to greenhouse gas emissions. Contaminants in pit latrines can migrate into surface water and groundwater systems, posing risks to human health. The review discusses mitigation measures and future research directions. The pit latrine paradox aims to stimulate discussion and research for refining the technology to enhance its functionality while mitigating pollution and health risks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Inorganic & Nuclear
Mauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Beatrice Rangone, Elena Perin, Beatrice Ferrari, Maria Grazia Bottone, Domenico Osella
Summary: Two Pt(iv) conjugates containing perillic acid were successfully synthesized, with one showing excellent antiproliferative and antimetastatic activity on lung tumor cells, and various in vitro biological tests were conducted to decipher some aspects of its mechanism of action.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Physical
Taposi Chatterjee, Ersad Hossain, Samim Khan, Sourav Roy, Saikh Mohammad Wabaidur, Md Ataul Islam, Seikh Mafiz Alam, Mohammad Hedayetullah Mir
Summary: A Zn(II) based two-dimensional metal-organic framework (MOF) 1 has been synthesized by a slow diffusion method. Compound 1 exhibits photoluminescence property and undergoes in situ cis,cis- to cis,trans-isomerization under visible light. Non-covalent interactions within compound 1 have been investigated using Hirshfeld surface analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2023)