期刊
GENETIC EPIDEMIOLOGY
卷 33, 期 2, 页码 95-104出版社
WILEY-LISS
DOI: 10.1002/gepi.20357
关键词
case-parent studies; case-sibling studies; gene-environment independence; parental missingness
The case-only study and family-based study are two popular study designs for detecting gene-environment interactions. It is well known that the case-only analysis is efficient, but its validity relies crucially on the assumption of gene-environment independence in the study population. In contrast, the family-based analysis is robust to the violation of such an assumption, but is less efficient. We propose a two-stage study design for detecting gene-environment interactions, where a case-only study is performed at the first stage, and a case-parent/case-sibling study is performed at the second stage on a random subsample of the first-stage case sample as well as their parents/unaffected siblings. Statistical inference procedures are developed for the proposed two-stage study designs, which not only preserve the robustness property of the family-based analysis, but also utilize information from the case-only analysis to enhance estimation efficiency and testing power. Simulation results reveal both the robustness and efficiency of the proposed strategies. Genet. Epidemiol. 33:95-104, 2009. (C) 2008 Wiley-Liss, Inc.
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