期刊
GENESIS
卷 52, 期 8, 页码 713-737出版社
WILEY
DOI: 10.1002/dvg.22794
关键词
heart; sarcomere; trabeculation; cardiac chamber specification; epicardium; heart fields
资金
- British Heart Foundation [PG/08/007/24400]
- BBSRC [BB/J012866/1]
- Wellcome Trust (University of Manchester Faculty of Life Sciences) [092403/Z/10/Z]
- Biotechnology and Biological Sciences Research Council [1225759, 1065552] Funding Source: researchfish
- Wellcome Trust [092403/Z/10/Z] Funding Source: Wellcome Trust
- BBSRC [BB/J012866/1] Funding Source: UKRI
Genes required for an organism to develop to maturity (for which no other gene can compensate) are considered essential. The continuing functional annotation of the mouse genome has enabled the identification of many essential genes required for specific developmental processes including cardiac development. Patterns are now emerging regarding the functional nature of genes required at specific points throughout gestation. Essential genes required for development beyond cardiac progenitor cell migration and induction include a small and functionally homogenous group encoding transcription factors, ligands and receptors. Actions of core cardiogenic transcription factors from the Gata, Nkx, Mef, Hand, and Tbx families trigger a marked expansion in the functional diversity of essential genes from midgestation onwards. As the embryo grows in size and complexity, genes required to maintain a functional heartbeat and to provide muscular strength and regulate blood flow are well represented. These essential genes regulate further specialization and polarization of cell types along with proliferative, migratory, adhesive, contractile, and structural processes. The identification of patterns regarding the functional nature of essential genes across numerous developmental systems may aid prediction of further essential genes and those important to development and/or progression of disease. (C) 2014 The Authors. Genesis Published by Wiley Periodicals, Inc.
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