Review
Cell Biology
Xianchun Ruan, Zhaowei Zhang, Munire Aili, Xiang Luo, Qiang Wei, Demao Zhang, Mingru Bai
Summary: Mineralized tissues, such as teeth and bones, are difficult to repair due to their hardness, low permeability, and limited blood flow. Bone morphogenetic proteins (BMPs) play a crucial role in mineralized tissue formation and repair. Activin receptor-like kinase 3 (ALK3), a key transmembrane receptor, is important for transmitting BMP signals and influencing cellular responses. Recent research has shown that ALK3 is involved in the regulation of mineralized tissues and affects tooth and bone development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Daniel Bressan, Helena Marcolla Araujo
Summary: Embryonic dorsal-ventral (DV) patterning by BMPs in insects involves the establishment of BMP activity gradients by diffusible BMP ligands and Chordin/Sog antagonists. The relative roles of BMP and Toll pathways in DV patterning vary among different insect orders.
CURRENT OPINION IN INSECT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Patricia A. Miguez, Stephen A. Tuin, Adam G. Robinson, Joyce Belcher, Prapaporn Jongwattanapisan, Kimberly Perley, Vinicius de Paiva Goncalves, Arash Hanifi, Nancy Pleshko, Elisabeth R. Barton
Summary: Hesperidin has shown to enhance osteogenic markers and collagen matrix quality, potentially serving as an adjunct in regenerative bone therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Saigopalakrishna S. Yerneni, Juraj Adamik, Lee E. Weiss, Phil G. Campbell
Summary: Extracellular vesicles (EVs) can carry signaling molecules such as growth factors, regulating osteoblastogenesis. Engineered BMP2-loaded EVs can circulate dynamically inside and outside cells, inducing osteogenesis.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Polymer Science
Oana Gherasim, Alexandru Mihai Grumezescu, Valentina Grumezescu, Ecaterina Andronescu, Irina Negut, Alexandra Catalina Birca, Bianca Galateanu, Ariana Hudita
Summary: Osteoconductive and osteoinductive coatings are effective strategies for enhancing the integration of metallic implants with bone. Composite materials based on PLA and HAp benefit bone cell development, while the addition of osteogenic proteins contributes to new bone formation. Laser-processed composites show superior ability to promote osteoprogenitor cell adhesion, viability, and proliferation.
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Hyun Seok, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, Jong Hoon Park
Summary: The study compared the bone regeneration ability of bone scaffolds using particle and block bones with rhBMP-2, showing that rhBMP-2 with block bones resulted in significantly higher bone volume but also led to the formation of adipose tissue and void spaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Liwei Zhu, Yuzhe Liu, Ao Wang, Zhengqing Zhu, Youbin Li, Chenyi Zhu, Zhenjia Che, Tengyue Liu, He Liu, Lanfeng Huang
Summary: Bone morphogenetic protein (BMP) plays an important role in promoting bone healing, but its mechanism needs further exploration. By modifying implants to carry BMP and achieve slow and sustained release, effective bone healing can be stimulated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Benjamin Tajer, James A. Dutko, Shawn C. Little, Mary C. Mullins
Summary: The study explores the BMP2/7 heterodimer signaling mechanism in zebrafish embryos, revealing that BMP2 homodimers require nonredundant type I receptors Acvr1 and Bmpr1 for signaling, despite not being able to bind Acvr1 in vitro. The kinase activity of Acvr1 is essential for the signaling complex, suggesting that the potency of the heterodimer arises from recruiting both Acvr1 and Bmpr1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Biomedical
Yinbo Xiao, Hannah Donnelly, Mark Sprott, Jiajun Luo, Vineetha Jayawarna, Leandro Lemgruber, P. Monica Tsimbouri, R. M. Dominic Meek, Manuel Salmeron-Sanchez, Matthew J. Dalby
Summary: In the field of bone tissue regenerative medicine, the use of MSC-based tissue engineering strategies combined with growth factors (GFs) and biomaterials has drawn great interest. However, the optimization of interactions between biomaterials and MSCs, as well as the efficient delivery of GFs, remains a challenge. This study demonstrates that through plasma polymerization, tissue culture plates coated with poly (ethyl acrylate) (PEA) can provide an optimal environment for MSCs, with enhanced adhesion and binding of GFs. The combination of fibronectin (FN) and vitronectin (VN) on PEA surfaces results in the formation of a heterogeneous, open ECM network, promoting MSC differentiation into osteoblasts and inducing osteogenic intracellular signaling.
MATERIALS TODAY BIO
(2022)
Article
Oncology
Wangyang Meng, Han Xiao, Rong Zhao, Dong Li, Kuo Li, Yunchong Meng, Jiaping Chen, Yangwei Wang, Yongde Liao
Summary: In lung adenocarcinoma, BMP5 was identified as an independent protective prognostic factor, significantly correlated with EGFR expression and mutations, and potentially involved in targeted therapy. By co-expression with hub genes, the re-established risk model showed improved prognostic correlation and value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Gaoli Xu, Chenxi Shen, Haiyan Lin, Jian Zhou, Ting Wang, Ben Wan, Munerah Binshabaib, Tymour Forouzanfar, Guochao Xu, Nawal Alharbi, Gang Wu
Summary: This study synthesized a novel biomimetically-precipitated nanocrystalline calcium phosphate (BpNcCaP) with internally incorporated bone morphogenetic protein-2 (BpNcCaP + BMP-2), demonstrating its potential application in repairing large-volume bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Martijn A. J. Koppens, Hayley Davis, Gabriel N. Valbuena, Eoghan J. Mulholland, Nadia Nasreddin, Mathilde Colombe, Agne Antanaviciute, Sujata Biswas, Matthias Friedrich, Lennard Lee, Lai Mun Wang, Viktor H. Koelzer, James E. East, Alison Simmons, Douglas J. Winton, Simon J. Leedham
Summary: The study reveals that BMP signaling inhibits dedifferentiation of intestinal epithelial cells, and attenuation of the BMP pathway through stromal upregulation of Grem1 is essential for adaptive reprogramming in intestinal regeneration. However, the functional impact of this intervention is submaximal, suggesting potential therapeutic pathway manipulation in inflammatory bowel disease.
Article
Dentistry, Oral Surgery & Medicine
Maria del Mar Ferra-Canellas, Marta Munar-Bestard, Laura Garcia-Sureda, Beatrice Lejeune, Joana Maria Ramis, Marta Monjo
Summary: The study demonstrates that low-dose BMP4 MI treatment has anti-inflammatory and regenerative properties on gingival fibroblasts, and improves cell viability in 3D gingiva under inflammatory conditions.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Entomology
Sara Cabral, Adriano De Paula, Richard Samuels, Rodrigo Da Fonseca, Simone Gomes, Jose Roberto Silva, Flavia Mury
Letter
Multidisciplinary Sciences
Pablo R. Goncalves, Fabio Di Dario, Ana C. Petry, Rodrigo L. Martins, Rodrigo N. da Fonseca, Malinda D. Henry, Francisco de Assis Esteves, Carlos R. Ruiz-Miranda, Leandro R. Monteiro, Marcelo T. Nascimento
Article
Multidisciplinary Sciences
Vitor Lima Coelho, Tarcisio Fontenele de Brito, Ingrid Alexandre de Abreu Brito, Maira Arruda Cardoso, Mateus Antonio Berni, Helena Maria Marcolla Araujo, Michael Sammeth, Attilio Pane
Summary: This study presents the stage-specific transcriptomes of Rhodnius prolixus during oogenesis, significantly improving the genome annotations for over 9000 genes and discovering more than 2000 novel genes. The data reveals key genes involved in germline development, genome integrity, and early embryonic development, shedding new light on the biological processes in this medically relevant insect.
SCIENTIFIC REPORTS
(2021)
Article
Fisheries
Jessica Fernandes de Souza, Andressa de Abreu Mello, Taynan Motta Portal, Rodrigo Nunes-da-Fonseca, Cintia Monteiro de Barros
Summary: DA, an important neurotransmitter, can modulate NO production in immune cells through adrenergic receptors in ascidian animals. The presence of catecholaminergic receptors on ascidian immune cells suggests unique pharmacological characteristics that may have evolutionary significance.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Parasitology
Juliana Figueiredo Peixoto, Daniele Gracas dos Santos, Lupis Ribeiro, Vitor Silva Candido de Oliveira, Rodrigo Nunes-da-Fonseca, Jose Luciano Nepomuceno-Silva
Summary: Trichomonas vaginalis is a parasite causing trichomoniasis in the human urogenital tract. When subjected to stressful conditions, it can differentiate into cyst-like stages showing resistance to unfavorable conditions. Research indicates that during this differentiation process, the mRNA of the meiotic recombinase Dmc1 is upregulated, suggesting potential cryptic sexual events in the cyst-like stages of T. vaginalis.
Article
Multidisciplinary Sciences
Natalia Martins Feitosa, Emiliano Nicolas Calderon, Rhenna Nascimento da Silva, Sonia Lopes Rezende de Melo, Jackson Souza-Menezes, Rodrigo Nunes-da-Fonseca, Marcia Vieira Reynier
Summary: The fish embryo test (FET) is an alternative method for assessing environmental hazards and risks to fish, with the Brazilian silverside identified as a euryhaline test species due to its ability to adapt to various salinity conditions and environments. The study demonstrates the advantages of using Brazilian silverside as a model for marine fish embryo tests, showing high reproducibility and minimal waste contamination in the process.
Review
Genetics & Heredity
Diego Guerra-Almeida, Diogo Antonio Tschoeke, Rodrigo Nunes-da-Fonseca
Summary: This review proposes a classification of smORFs based on transcriptional features and discusses promising approaches to investigate them. SmORFs are potentially important coding sequences that have been historically overlooked, but are now gaining attention in systems biology.
Article
Biochemical Research Methods
Claudio D. T. Barros, Maira A. Cardoso, Paulo M. Bisch, Helena M. Araujo, Francisco J. P. Lopes
Summary: The dorsal-ventral patterning of the Drosophila embryo relies on the dynamic balance of Dorsal and Cactus between the cytoplasm and nucleus, with different roles of Dorsal-Cactus trimers in the presence or absence of Toll receptor activation. A predictive model demonstrates the essential role of Cactus in regulating the nuclear translocation of transcription factor Dorsal.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Natalia Martins Feitosa, Bruno da Costa Rodrigues, Ana Cristina Petry, Keity Jaqueline Chagas Vilela Nocchi, Rodrigo de Moraes Brindeiro, Carla Zilberberg, Cintia Monteiro-de-Barros, Flavia Borges Mury, Jackson de Souza-Menezes, Jose Luciano Nepomuceno-Silva, Manuela Leal da Silva, Marcio Jose de Medeiros, Raquel de Souza Gestinari, Alessandra da Silva de Alvarenga, Allan Pierre Bonetti Pozzobon, Carina Azevedo Oliveira Silva, Daniele das Gracas dos Santos, Diego Henrique Silvestre, Graziele Fonseca de Sousa, Janimayri Forastieri de Almeida, Jhenifer Nascimento da Silva, Layza Mendes Brandao, Leandro de Oliveira Drummond, Lupis Ribeiro Gomes Neto, Raphael de Mello Carpes, Renata Coutinho dos Santos, Taynan Motta Portal, Amilcar Tanuri, Rodrigo Nunes-da-Fonseca
Summary: The Brazilian strategy to control the spread of COVID-19 has been criticized for the lack of national coordination and testing programs. In Macae, Brazil, a successful approach was achieved by engaging public and private sectors, leading to effective control of COVID-19 transmission and lower fatality rates compared to other cities in the state. Comprehensive testing, spatial analysis, and prompt notification were key factors in preventing catastrophic consequences of the pandemic in Macae.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Daniel Bressan, Helena Marcolla Araujo
Summary: Embryonic dorsal-ventral (DV) patterning by BMPs in insects involves the establishment of BMP activity gradients by diffusible BMP ligands and Chordin/Sog antagonists. The relative roles of BMP and Toll pathways in DV patterning vary among different insect orders.
CURRENT OPINION IN INSECT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
H. F. Loponte, I. A. Oliveira, B. C. Rodrigues, R. Nunes-da-Fonseca, R. Mohana-Borges, F. Alisson-Silva, W. B. Dias, A. R. Todeschini
Summary: Diabetes Mellitus is correlated with colorectal cancer, with hyperglycemia leading to aberrant glycosylation of CRC cells. Mass spectrometry identified 67 N-glycans in MC38 cells, with a greater abundance in hyperglycemic conditions. Differential expression of 16 N-glycans, mostly mannosylated and fucosylated, was observed.
GLYCOCONJUGATE JOURNAL
(2022)
Article
Genetics & Heredity
Marcus Berni, Leonardo Lima, Daniel Bressan, Alison Julio, Larissa Bonfim, Yasmin Simao, Attilio Pane, Isabela Ramos, Pedro L. Oliveira, Helena Araujo
Summary: This study conducted functional analysis of eye and cuticle pigmentation genes in kissing bugs that transmit Chagas disease, revealing important insights into the generation of color in this blood-feeding hemiptera.
Article
Multidisciplinary Sciences
Graziele Fonseca de Sousa, Thuany da Silva Nogueira, Lana Soares de Sales, Fernanda Ferreira Maissner, Odara Araujo de Oliveira, Hellade Lopes Rangel, Daniele das Gracas dos Santos, Rodrigo Nunes-da-Fonseca, Jackson de Souza-Menezes, Jose Luciano Nepomuceno-Silva, Flavia Borges Mury, Raquel de Souza Gestinari, Amilcar Tanuri, Orlando da Costa Ferreira, Cintia Monteiro-de-Barros
Summary: This study analyzed the long-term dynamics of antibodies against SARS-CoV-2 in 231 COVID-19 positive patients over a seven-month period. The results showed sustained production of IgA and IgM antibodies for three months, and continued production of IgG antibodies for over seven months. Age and viral load were found to have an impact on antibody production, while gender did not show a significant difference.
Article
Biochemistry & Molecular Biology
M. Berni, J. Mota, D. Bressan, L. Ribeiro, G. Martins, J. Pereira, I. Ramos, R. Nunes-da-Fonseca, H. Araujo
Summary: Dorsal-ventral (DV) patterning is regulated by the bone morphogenetic pathway (BMP) in Bilateria, with the Toll pathway also playing a role in insect DV patterning. The study of Rhodnius prolixus shows that BMP pathway controls the entire DV axis in this hemiptera species and that the Sog and Tsg proteins have a positive role in establishing a dorsal-to-ventral BMP gradient, which differs from other insect species.
