Article
Cardiac & Cardiovascular Systems
Jessica E. Hook, Dennis R. Delany, Jason R. Buckley, Shahryar M. Chowdhury, Minoo N. Kavarana, John M. Costello
Summary: We conducted a study using the Pediatric Health Information System Database to identify factors associated with mortality and adverse outcomes in infants undergoing truncus arteriosus repair from 2004 to 2019. We found that factors such as low birth weight, early admission, truncal valve surgery, cardiac arrest, extracorporeal membrane oxygenation, and acute kidney injury were associated with increased mortality. This information can be utilized for quality improvement initiatives and perioperative counseling.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Phillip S. Naimo, Igor E. Konstantinov
Summary: Surgery for truncus arteriosus has a high early mortality rate and long-term survival challenge, but the long-term outcomes of truncus arteriosus repair are good, with many patients enjoying a quality of life comparable to the general population.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel L. Hames, Kimberly I. Mills, Ravi R. Thiagarajan, Sarah A. Teele
Summary: This study aimed to identify risk factors for mortality in infants with truncus arteriosus requiring perioperative ECMO. The results showed that factors independently associated with mortality included lower weight, longer ECMO duration, need for renal replacement therapy, cardio-pulmonary resuscitation on ECMO, and infection on ECMO.
ANNALS OF THORACIC SURGERY
(2021)
Article
Genetics & Heredity
Alistair T. Pagnamenta, Adam Jackson, Rahat Perveen, Glenda Beaman, Gemma Petts, Asheeta Gupta, Zerin Hyder, Brian Hon-Yin Chung, Anita Sik-Yau Kan, Ka Wang Cheung, Wilhelmina S. Kerstjens-Frederikse, Kristin M. Abbott, Orly Elpeleg, Jenny C. Taylor, Siddharth Banka, Asaf Ta-Shma
Summary: This study confirms the genetic basis of SHDRA, expands its known mutational spectrum, and clarifies its clinical features. SHDRA is a severe condition associated with substantial mortality in early childhood, characterized by congenital cardiac malformations with a variable renal phenotype.
Article
Cardiac & Cardiovascular Systems
Jason R. Buckley, John M. Costello, Arthur J. Smerling, Peter Sassalos, Venu Amula, Katherine Cashen, Christine M. Riley, Adnan M. Bakar, Ilias Iliopoulos, Aimee Jennings, Sukumar Suguna Narasimhulu, Christopher W. Mastropietro
Summary: This retrospective cohort study evaluated the outcomes of 35 children who underwent repair of TA-IAA in 12 tertiary care referral centers in the United States. The rate of MACE was 34%, which was higher than that of TA patients but not statistically significant. The study suggested that early childhood outcomes of patients with TA-IAA were similar to those with TA.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Phillip S. Naimo, Douglas Bell, Tyson A. Fricke, Yves d'Udekem, Christian P. Brizard, Nelson Alphonso, Igor E. Konstantinov
Summary: Truncus arteriosus repair in neonates presents significant surgical challenges, but survival beyond the first year following repair is associated with excellent outcomes. Neonatal surgery and low operative weight are risk factors for early mortality, while a coronary artery anomaly is a risk factor for late mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Manan H. Desai, Aybala Tongut, Karthik Ramakrishnan, Can Yerebakan, Pranava Sinha, Richard Jonas, Syed M. Peer
Summary: In neonates undergoing postcardiac surgery, sternal approximation can be challenging, especially in cases where a right ventricle-to-pulmonary artery homograft conduit is used. We describe a technique of pericardiophrenic release during delayed sternal closure to prevent hemodynamic compromise and conduit compression.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Carlos Bonilla-Ramirez, Christopher Ibarra, Ziyad M. Binsalamah, Iki Adachi, Jeffrey S. Heinle, E. Dean McKenzie, Christopher A. Caldarone, Michiaki Imamura
Summary: Coronary artery lesions are associated with increased mortality after truncus repair, with surgical intervention potentially improving survival for patients with fewer lesions. Patients with the most complex anomalies have poor survival outcomes and require ongoing study for repair techniques.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew L. Stone, Michal Schafer, Johannes C. von Alvensleben, Lorna P. Browne, Michael Di Maria, David N. Campbell, James Jaggers, Max B. Mitchell
Summary: This study found that children with repaired truncus arteriosus (TA) have abnormal ascending aortic biomechanical properties and altered left ventricular (LV) function. These changes can be detected by CMR imaging and are different from the control group. Additionally, it was observed that changes in LV function were independent of aortic biomechanical properties.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Aditya Sengupta, Kimberlee Gauvreau, Akalpit Shukla, Katherine Kohlsaat, Steven D. Colan, Pedro J. del Nido, John E. Mayer Jr, Meena Nathan
Summary: This study retrospectively analyzed cases of repaired truncus arteriosus (TA) and found that root dilatation in the aorta persisted for up to 30 years after surgery. Patients with bicuspid and quadricuspid truncal valves showed greater root dilatation over time and required more valve interventions. Long-term follow-up is necessary for these high-risk patients.
ANNALS OF THORACIC SURGERY
(2023)
Article
Veterinary Sciences
Oscar Monge-Utrilla, M. Belen Garcia-Rodriguez, Nerea Cuesta-Garcia, Inmaculada Diez-Prieto
Summary: This is a case report of a 10-month-old female domestic shorthaired cat presenting with severe respiratory issues. The cat exhibited dyspnea, tachypnea, cyanosis, weak pulse, and bradycardia. Physical examination revealed pulmonary crepitation, attenuated heart sounds, and a pansystolic grade V/VI murmur. Atrioventricular dissociation was identified on the electrocardiogram, indicating third-degree sinoatrial block. X-rays showed increased density in the thoracic ventral and middle zones, as well as loss of definition of the cardiac silhouette and increased diffuse radiographic density of the abdomen. Echocardiography revealed right atrium dilatation and concentric biventricular hypertrophy. Necropsy confirmed the diagnosis of type 1 persistent truncus arteriosus. This is the first report of this arrhythmia in a cat with persistent truncus arteriosus, and its association with the described congenital cardiac anomaly is discussed.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Alvise Guariento, Ilias P. Doulamis, Steven J. Staffa, Laura Gellis, Nicholas A. Oh, Takashi Kido, John E. Mayer, Christopher W. Baird, Sitaram M. Emani, David Zurakowski, Pedro J. Del Nido, Meena Nathan
Summary: This study identified that a smaller right ventricle to pulmonary artery conduit size and truncal valve insufficiency at birth were associated with overall mortality after truncus arteriosus repair. The size of the conduit at index surgery was the most important factor for early reoperation and catheter-based reintervention.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Genetics & Heredity
Lihong Pu, Jiao Chen
Summary: This study presented a case of a fetus with trisomy 13 diagnosed with truncus arteriosus accompanied by absent semilunar valve. The identification of such significant heart malformation in the first trimester allows timely access to specialist counselling and genetic diagnosis.
PRENATAL DIAGNOSIS
(2021)
Article
Genetics & Heredity
Rishika P. Sakaria, Parul G. Zaveri, Shannon Holtrop, Jie Zhang, Chester W. Brown, Eniko K. Pivnick
Summary: Kabuki syndrome is a rare multiple anomalies syndrome associated with mutations in KMT2D or KDM6A, characterized by infantile hypotonia, developmental delay and/or intellectual disability, long palpebral fissures, and typical facial features. Intracranial anomalies are infrequent, with a report describing a rare case with holoprosencephaly.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Leona S. Alizadeh, Vitali Koch, Leon D. Gruenewald, Ibrahim Yel, Daniel Mathies, Dominic Rauschning, Thomas J. Vogl, Christian Booz
Summary: Truncus arteriosus (TA) is a rare congenital anomaly that has complex cardiovascular anatomy and is associated with severe complications and pathologies. Understanding and treating TA and its complications are crucial for the survival and outcome of patients.
Article
Cell & Tissue Engineering
Raga Krishnakumar, Amy F. Chen, Marisol G. Pantovich, Muhammad Danial, Ronald J. Parchem, Patricia A. Labosky, Robert Blelloch
Article
Biochemistry & Molecular Biology
Frederick J. Meyers, Ambika Mathur, Cynthia N. Fuhrmann, Theresa C. O'Brien, Inge Wefes, Patricia A. Labosky, D'Anne S. Duncan, Avery August, Andrew Feig, Kathleen L. Gould, Michael J. Friedlander, Chris B. Schaffer, Audra Van Wart, Roger Chalkley
Article
Developmental Biology
Floor J. Stam, Timothy J. Hendricks, Jingming Zhang, Eric J. Geiman, Cedric Francius, Patricia A. Labosky, Frederic Clotman, Martyn Goulding
Article
Developmental Biology
Nathan A. Mundell, Patricia A. Labosky
Article
Developmental Biology
Erez Nitzan, Shlomo Krispin, Elise R. Pfaltzgraff, Avihu Klar, Patricia A. Labosky, Chaya Kalcheim
Article
Developmental Biology
Rachel B. Reinert, Qing Cai, Ji-Young Hong, Jennifer L. Plank, Kristie Aamodt, Nripesh Prasad, Radhika Aramandla, Chunhua Dai, Shawn E. Levy, Ambra Pozzi, Patricia A. Labosky, Christopher V. E. Wright, Marcela Brissova, Alvin C. Powers
Article
Developmental Biology
Jennifer L. Plank, Nathan A. Mundell, Audrey Y. Frist, Alison W. LeGrone, Thomas Kim, Melissa A. Musser, Teagan J. Walter, Patricia A. Labosky
DEVELOPMENTAL BIOLOGY
(2011)
Article
Developmental Biology
Nathan A. Mundell, Jennifer L. Plank, Alison W. LeGrone, Audrey Y. Frist, Lei Zhu, Myung K. Shin, E. Michelle Southard-Smith, Patricia A. Labosky
DEVELOPMENTAL BIOLOGY
(2012)
Article
Endocrinology & Metabolism
Jennifer L. Plank, Audrey Y. Frist, Alison W. LeGrone, Mark A. Magnuson, Patricia A. Labosky
Article
Cardiac & Cardiovascular Systems
Elise R. Pfaltzgraff, Elaine L. Shelton, Cristi L. Galindo, Brian L. Nelms, Christopher W. Hooper, Stanley D. Poole, Patricia A. Labosky, David M. Bader, Jeff Reese
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2014)
Article
Multidisciplinary Sciences
Erez Nitzan, Elise R. Pfaltzgraff, Patricia A. Labosky, Chaya Kalcheim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Cell & Tissue Engineering
Jennifer L. Plank, Michael T. Suflita, Cristi L. Galindo, Patricia A. Labosky
STEM CELL RESEARCH
(2014)
Article
Cell & Tissue Engineering
Michael T. Suflita, Elise R. Pfaltzgraff, Nathan A. Mundell, Larysa H. Pevny, Patricia A. Labosky
STEM CELLS AND DEVELOPMENT
(2013)
Article
Multidisciplinary Sciences
Elise R. Pfaltzgraff, Nathan A. Mundell, Patricia A. Labosky
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2012)
Article
Cell Biology
Alexandra M. Ainsztein, Philip J. Brooks, Vivien G. Dugan, Aniruddha Ganguly, Max Guo, T. Kevin Howcroft, Christine A. Kelley, Lillian S. Kuo, Patricia A. Labosky, Rebecca Lenzi, George A. Mckie, Suresh Mohla, Dena Procaccini, Matthew Reilly, John S. Satterlee, Pothur R. Srinivas, Elizabeth Stansell Church, Margaret Sutherland, Danilo A. Tagle, Jessica M. Tucker, Sundar Venkatachalam
JOURNAL OF EXTRACELLULAR VESICLES
(2015)