Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Physiology
Ghazi-Abdullah Saroya, Erica Siismets, Max Hu, Christopher Panaretos, Adam Rice, Kurt Reynolds, Chengji J. J. Zhou, Vesa Kaartinen
Summary: The secondary palate is formed through the contact and subsequent fusion of two lateral primordia called palatal shelves. The gene encoding Tgfb3 is specifically expressed in the medline edge epithelia (MEE) cells, and its expression is controlled by upstream cis-regulatory elements near the Ift43 gene. Beta-Catenin, a component of the canonical Wnt signaling pathway, is responsible for the MEE-specific Tgfb3 expression. However, our study shows that deletion of the Ctnnb1 gene in basal MEE cells does not affect Tgfb3 expression or palatal epithelial fusion, suggesting that epithelial beta-catenin may not be required for these processes.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Bohui Sun, Yangjia Liu, Wenbin Huang, Qian Zhang, Jiuxiang Lin, Weiran Li, Jieni Zhang, Feng Chen
Summary: The study revealed that a rare VEGFA mutation has adverse effects on cell functions and osteogenesis, impacting palate development. This mutation may lead to nonsyndromic cleft lip with or without cleft palate and provides new insights into the mechanism of VEGFA gene in osteogenesis and palatogenesis.
Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lauren K. K. Wareham, Amy E. E. Whitener, Hang-Jing Wu, Shu-Yu Wu, Hassane S. S. Mchaourab, Douglas P. P. Mortlock, Rachel W. W. Kuchtey, John Kuchtey
Summary: Mutations in ADAMTS10 can cause different ocular diseases, glaucoma in dogs and Weill-Marchesani Syndrome in humans. This study shows that ADAMTS10 plays a crucial role in retinal ganglion cell development through regulation of TGF beta signaling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Dieuwke L. Marvin, Vivian M. Spaans, Cor D. De Kroon, Roderick C. Slieker, Maryam Khelil, Peter Ten Dijke, Laila Ritsma, Ekaterina S. Jordanova
Summary: Cervical cancer is the fourth most common cancer in women worldwide, with adenocarcinoma patients having a worse prognosis. The tumor suppressor function of TGF-beta is lost in tumor cells. Analysis of RNA-seq data showed that TGF-beta plays different roles in squamous cell carcinoma and adenocarcinoma. In adenocarcinoma patients, low expression of T beta R2 and SMAD4 was associated with worse survival, while high expression of PAI-1 and alpha v beta 6 was also correlated with worse survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ke-Xin Zheng, Shou-Li Yuan, Meng Dong, Han-Lin Zhang, Xiao-Xiao Jiang, Chun-Long Yan, Rong-Cai Ye, Hui-Qiao Zhou, Li Chen, Rui Jiang, Zi-Yu Cheng, Zhi Zhang, Qi Wang, Wan-Zhu Jin, Wen Xie
Summary: In this study, we identified dihydroergotamine (DHE) as a potential drug for treating liver fibrosis by targeting TGF beta R2 and inhibiting the TGF beta signaling pathway. DHE was shown to reduce fibrotic gene expressions and improve liver fibrosis in both cellular and mouse models.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Toxicology
Xiaozhuan Liu, Yuwei Zhang, Lijun Shen, Zhidong He, Yao Chen, Ning Li, Xiuli Zhang, Tingting Zhang, Suhua Gao, Haodi Yue, Zhitao Li, Zengli Yu
Summary: Treatment with all-trans retinoic acid (atRA) promotes the upregulation of Meg3 in mouse embryonic palate mesenchymal (MEPM) cells, leading to a suppression of cell proliferation potentially through interacting with Smad2 protein to inhibit Smad signaling.
TOXICOLOGY LETTERS
(2021)
Article
Developmental Biology
Eva Janeckova, Jifan Feng, Tingwei Guo, Xia Han, Aileen Ghobadi, Angelita Araujo-Villalba, Md Shaifur Rahman, Heliya Ziaei, Thach-Vu Ho, Siddhika Pareek, Jasmine Alvarez, Yang Chai
Summary: This study reveals the crucial role of Wnt signaling in soft palate development and muscle differentiation through the regulation of ciliary homeostasis. Wnt signaling activates ciliary gene Ttll3 expression, which is necessary for mesenchymal cell proliferation and subsequent myogenesis.
Review
Ophthalmology
Steven E. Wilson
Summary: This review highlights the interactions and regulatory roles of interleukin (IL)-1 and transforming growth factor (TGF) beta in the corneal wound healing process. Both systems play crucial roles in regulating cellular functions and gene expressions during the healing response to injuries or infections, and their coordinated downregulation is necessary to terminate the response and prevent fibrosis in the cornea. Understanding the IL-1 and TGF beta systems better can lead to improved approaches for controlling excessive healing responses and scarring corneal fibrosis caused by infections and injuries.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Microbiology
Wei Zhang, Yiwei Lin, Yang Zong, Xin Ma, Chaolai Jiang, Haojie Shan, Wenyang Xia, Lifu Yin, Nan Wang, Lihui Zhou, Zubin Zhou, Xiaowei Yu
Summary: Hypoxia-induced factor-1 alpha (HIF-1 alpha) and transforming growth factor beta 1 (TGF-beta 1) play important roles in the pathogenesis of osteomyelitis induced by Staphylococcus aureus. This study suggests a novel signaling cascade involving hypoxia/HIF-1 alpha/TGF-beta 1, which could potentially serve as a target for therapeutic measures against osteomyelitis.
Article
Pediatrics
Zufit Hexner-Erlichman, Boris Fichtman, Yoav Zehavi, Morad Khayat, Haneen Jabaly-Habib, Lee S. Izhaki-Tavor, Moshe Dessau, Orly Elpeleg, Ronen Spiegel
Summary: Cleft lip and/or cleft palate are common birth defects that can be syndromic or non-syndromic. This report describes a novel syndrome associated with LRRC32 gene mutations, expanding our understanding of the clinical features of cleft palate, proliferative retinopathy and developmental delay syndrome.
FRONTIERS IN PEDIATRICS
(2022)
Article
Neurosciences
Debora Denardin Luckemeyer, Wenrui Xie, Arthur Silveira Prudente, Katherine A. Qualls, Raquel Tonello, Judith A. Strong, Temugin Berta, Jun-Ming Zhang
Summary: Through experiments, researchers found that the TGF-beta signaling pathway plays an important role in local sympathetic blockade by regulating macrophages in the DRG and its anti-inflammatory actions to alleviate pain behaviors.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Yanan Min, Long Hao, Xinguang Liu, Shuai Tan, Hui Song, Hao Ni, Zi Sheng, Natalie Jooss, Xuena Liu, Rickard E. Malmstrom, Yang Sun, Jianguo Liu, Hua Tang, Hao Zhang, Chunhong Ma, Jun Peng, Ming Hou, Nailin Li
Summary: This study investigated the mechanisms underlying the regulation of effector responses of naive CD4(+) T (Tn) cells by platelets. The results showed that platelets exert sophisticated regulation on various types of T helper cells and regulatory T cells in a time-, concentration-, and organ-dependent manner, in cooperation with transforming growth factor beta (TGF beta) and platelet factor 4 (PF4). This study highlights the importance of platelet-targeted interventions for T cell immunity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl-Henrik Heldin, Aristidis Moustakas
Summary: This review summarizes the impact of extracellular vesicles (EVs) on the transforming growth factor beta (TGF-beta) signaling pathway in cancer. The cargo of EVs, including various molecules associated with TGF-beta pathway, can influence tumorigenesis, metastatic spread, immune evasion, and response to treatment. Additionally, TGF-beta-related molecules in circulating EVs show potential as useful biomarkers for prognosis, diagnosis, and treatment response in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Jamie Lane, Kenji Yumoto, Mohamad Azhar, Jun Ninomiya-Tsuji, Maiko Inagaki, Yingling Hu, Chu-Xia Deng, Jieun Kim, Yuji Mishina, Vesa Kaartinen
DEVELOPMENTAL BIOLOGY
(2015)
Article
Developmental Biology
Shailesh Agarwal, Shawn J. Loder, Cameron Brownley, Oluwatobi Eboda, Jonathan R. Peterson, Satoru Hayano, Bingrou Wu, Bin Zhao, Vesa Kaartinen, Victor C. Wong, Yuji Mishina, Benjamin Levi
DEVELOPMENTAL BIOLOGY
(2015)
Article
Developmental Biology
Ali Darehzereshki, Nicole Rubin, Laurent Gamba, Jieun Kim, James Fraser, Ying Huang, Joshua Billings, Robabeh Mohammadzadeh, John Wood, David Warburton, Vesa Kaartinen, Ching-Ling Lien
DEVELOPMENTAL BIOLOGY
(2015)
Article
Physiology
Wei Xu, Chengyu Liu, Vesa Kaartinen, Hui Chen, Chi-Han Lu, Wenming Zhang, Yongfeng Luo, Wei Shi
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2013)
Article
Neurosciences
Sven Falk, Esmee Joosten, Vesa Kaartinen, Lukas Sommer
Article
Developmental Biology
Xiaoying Bai, Jennifer J. Trowbridge, Elizabeth Riley, Joseph A. Lee, Anthony DiBiase, Vesa M. Kaartinen, Stuart H. Orkin, Leonard I. Zon
DEVELOPMENTAL BIOLOGY
(2013)
Article
Developmental Biology
Penny S. Thomas, Sudha Rajderkar, Jamie Lane, Yuji Mishina, Vesa Kaartinen
DEVELOPMENTAL BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Kenji Yumoto, Penny S. Thomas, Jamie Lane, Kouichi Matsuzaki, Maiko Inagaki, Jun Ninomiya-Tsuji, Gregory J. Scott, Manas K. Ray, Mamoru Ishii, Robert Maxson, Yuji Mishina, Vesa Kaartinen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Penny S. Thomas, Somyoth Sridurongrit, Pilar Ruiz-Lozano, Vesa Kaartinen
Article
Medicine, Research & Experimental
Jamie Lane, Vesa Kaartinen
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
(2014)
Article
Genetics & Heredity
Caterina Clementi, Swamy K. Tripurani, Michael J. Large, Mark A. Edson, Chad J. Creighton, Shannon M. Hawkins, Ertug Kovanci, Vesa Kaartinen, John P. Lydon, Stephanie A. Pangas, Francesco J. DeMayo, Martin M. Matzuk
Article
Physiology
Jamie Lane, Kenji Yumoto, Justin Pisano, Mohamad Azhar, Penny S. Thomas, Vesa Kaartinen
FRONTIERS IN PHYSIOLOGY
(2014)
Article
Multidisciplinary Sciences
Se-Jin Lee, Adam Lehar, Yewei Liu, Chi Hai Ly, Quynh-Mai Pham, Michael Michaud, Renata Rydzik, Daniel W. Youngstrom, Michael M. Shen, Vesa Kaartinen, Emily L. Germain-Lee, Thomas A. Rando
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Developmental Biology
Teng Teng, Camilla S. Teng, Vesa Kaartinen, Jeffrey O. Bush
Summary: In tissue fusion, the removal of a midline epithelial seam (MES) is achieved through the migration of epithelial trails and islands, accompanied by cell differentiation and anisotropic actomyosin contractility. These findings demonstrate redundancy in cellular mechanisms of morphogenesis and reveal a unique form of collective epithelial migration during tissue fusion.
Article
Cardiac & Cardiovascular Systems
Shabber Syed, Sudha Rajderkar, Jeffrey M. Mann, Travis Hawkins, Bingrou Wu, Bin Zhou, Yukiko Sugi, Yuji Mishina, Vesa Kaartinen
Summary: This study investigates the role of AcvRI in aortic valve disease using a mouse model, and finds that continuous AcvRI activity leads to pathological changes in the structure and function of the aortic valve. The study also identifies alterations in gene sets associated with inflammation-related cytokine signaling, smooth muscle cell contraction, and cGMP signaling.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)