Article
Clinical Neurology
Giovana R. Sabadin, Eduarda Biasuz, Julia Canzian, Isaac A. Adedara, Denis B. Rosemberg
Summary: This study proposed a novel behavioral paradigm to simultaneously assess geotaxis and scototaxis as anxiety-like responses in zebrafish. The results showed good predictive validity of this paradigm and adherence to the 3Rs principle.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Carly L. Clayman, Victoria P. Connaughton
Summary: This study examines the neuropharmacological and behavioral consequences of caffeine and alcohol exposure in zebrafish model, highlighting the potential of alcohol as an anxiolytic substance that could offset the anxiogenic effects of caffeine and affect neural circuit development.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Environmental Sciences
Asma Al Shuraiqi, Aziz Al-Habsi, Michael J. Barry
Summary: Despite the publication of numerous papers, the effects of fluoxetine on fish behavior remain controversial and contradictory. This study exposed adult zebrafish to various concentrations of fluoxetine and found that the effects varied over time and in a non-monotonic manner, suggesting a complex interaction between the serotonergic system and environmental stimuli.
ENVIRONMENTAL POLLUTION
(2021)
Article
Psychology, Multidisciplinary
Maria Elena Miletto Petrazzini, Linda Gambaretto, Marco Dadda, Caroline Brennan, Christian Agrillo
Summary: This study investigated the relationship between neuroanatomical or behavioral lateralization and anxiety in adult zebrafish using a light-dark preference test. The results from both experiments indicate that neither behavioral nor neuroanatomical asymmetries are related to anxiety-related behaviors measured in the light-dark test.
Article
Environmental Sciences
Amira Abozaid, Robert Gerlai
Summary: Anxiety is a significant medical need, but current pharmacotherapy options are often ineffective. The zebrafish has emerged as a promising animal model for studying anxiolytic drugs. This study investigated the effects of buspirone hydrochloride on zebrafish behavior and found that it reduced movement and thigmotaxis while increasing immobility duration and turn angle. These findings suggest that juvenile zebrafish could be a useful model for evaluating the effects of anxiolytic drugs.
Article
Environmental Sciences
Ziyue Shi, Xuefang Liang, Yaqian Zhao, Wang Liu, Christopher J. Martyniuk
Summary: This study evaluated the potential neurotoxicity of three synthetic phenolic antioxidants (SPAs) on zebrafish larvae. The results showed that different SPAs had different effects on the behavior and gene expression of zebrafish, possibly through modulation of signaling pathways such as dopamine, serotonin, and GABA, leading to neurotoxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
William Andrew Thompson, Zachary Shvartsburd, Mathilakath M. Vijayan
Summary: Excessive use of antidepressants has led to their increased presence in aquatic habitats. Venlafaxine, one commonly prescribed antidepressant, has been shown to be detrimental to the early life stages of fish. This study found that early-life exposure to venlafaxine leads to behavioral and metabolic perturbations in adult zebrafish, with effects varying between sexes.
Article
Psychology, Biological
Priscila F. Silva, Carlos Garcia de Leaniz, Fulvio A. M. Freire, Vanessa A. M. Silveira, Ana C. Luchiari
Summary: This study investigated the effects of two potential variables, fish origin and environmental parameters, on zebrafish behavior. The results showed that increased light intensity led to changes in fish behavior, specifically an increase in freezing duration and distance from the bottom of the tank, indicating increased anxiety. Swimming activity increased at the lowest temperature (25 degrees C), but different levels of background noise did not cause significant behavioral changes. Differences were also observed between zebrafish strains and populations, with the AB strain from laboratory 2 being more affected by changes in temperature, light, and background noise compared to the AB strain from laboratory 1. The study highlights the importance of considering and reporting variation in strains and holding conditions to improve data interpretation and reproducibility.
BEHAVIOURAL PROCESSES
(2023)
Article
Neurosciences
Nikita Deo, Gregory Redpath
Summary: This article examines the important role of endocytosis in the cellular basis of depression and anxiety. It provides a detailed explanation of the endocytic regulation of 5-HT receptors and SERT, and explores how SSRIs and hallucinogenic compounds modulate serotonin signaling through endocytosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Nuria Saiz, Lisbeth Herrera-Castillo, Nuria de Pedro, Maria Jesus Delgado, Sven David Arvidsson, Miguel Angel Marugal-Lopez, Esther Isorna
Summary: This research investigates the effects of disruption of circadian rhythms on stress and anxiety-like behavior in fish. The study finds that both continuous light and randomly scheduled meals induce anxiety-like behavior and increased energy expenditure in goldfish. The findings also suggest a possible chronic stress response in fish under continuous light. These results highlight the importance of considering circadian disruption for animal welfare.
Article
Chemistry, Multidisciplinary
Ana C. Quevedo, Iseult Lynch, Eugenia Valsami-Jones
Summary: Evaluation of uptake mechanisms of silver nanoparticles of different sizes in zebrafish cells revealed size- and time-dependent uptake patterns and showed strong associations with endocytosis pathways and autophagy induction. These findings provide insights into the cellular processes of nanoparticle uptake and suggest potential implications for risk assessment and nanomaterial development.
Article
Biochemistry & Molecular Biology
Alyssa M. West, Katherine M. Holleran, Sara R. Jones
Summary: The serotonin and kappa opioid receptor (KOR) systems play important roles in disorders of negative affect. In this study, the researchers investigated the effects of KOR activation and serotonin reuptake inhibition on serotonin transmission in the substantia nigra pars reticulata (SNr). They found that KOR activation reduced serotonin release and uptake, while serotonin reuptake inhibition increased serotonin release and slowed reuptake. The researchers also demonstrated that short-term activation of KOR altered serotonin responses to reuptake inhibition. These findings highlight the complex interactions between KORs and serotonin in regulating negative affect, and suggest that the KOR system may be a promising target for treating disorders such as anxiety and depression alongside traditional antidepressant treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Heloysa Araujo-Silva, Augusto Monteiro de Souza, Joao Paulo Medeiros Mamede, Silvia Regina Batistuzzo de Medeiros, Ana Carolina Luchiari
Summary: This study evaluated the gene expression and behavior of bold and shy individuals after exposure to alcohol and nicotine. The results showed that alcohol and nicotine had different effects on behavior and gene expression in the two profiles, increasing anxiety in bold fish and decreasing anxiety in shy fish. These findings further support the use of zebrafish as a dependable tool for studying the effects of drugs and individual variations.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Article
Behavioral Sciences
Omer A. Syed, Benjamin Tsang, Robert Gerlai
Summary: This review discusses the possible utility of zebrafish in psilocybin research. The analysis focuses on behavioral tests, genetic manipulations, mechanisms, safety, toxicity profile, and treatment efficacy testing in zebrafish. The review concludes that zebrafish has a promising future in preclinical research on psychedelic drugs.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Environmental Sciences
Huiting Yang, Xuefang Liang, Yanyan Zhao, Xiaohong Gu, Zhigang Mao, Qingfei Zeng, Huihui Chen, Christopher J. Martyniuk
Summary: The study investigated the behavioral and molecular responses in larval fish following exposure to different concentrations of SER. It was found that exposure to SER altered the behavior of early-stage zebrafish, with changes in locomotor activity and dark-avoidance. Additionally, an increase in mRNA levels of serotonin transporter and serotonin receptor 2c was observed in fish exposed to 10 μg/L SER.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Behavioral Sciences
Waldo Lucas Luz, Mateus Santos-Silva, Patrick Bruno Cardoso, Nadyme Assad, Edinaldo Rogerio da Silva Moraes, Alan Barroso Araujo Grisolia, Danielle Valente Braga, Luana Ketlen Reis Leao, Suellen Alessandra Soares de Moraes, Adelaide da Conceicao Passos, Evander de Jesus Oliveira Batista, Amauri Gouveia, Karen R. H. Matos Oliveira, Anderson Manoel Herculano
Summary: Acute stress can induce anxiety-like behavior, increased lipid peroxidation, and decreased GABA levels in the brains of zebrafish. Stimulation of CB1 receptors can prevent stress-induced anxiety and oxidative stress, as well as maintain GABA levels in the brain. This suggests that CB1 receptors may be a potential target for treating anxiety disorders triggered by acute stress.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Ophthalmology
Juliana Bizerra Assis, Alodia Brasil, Terezinha Medeiros Goncalves Loureiro, Veronica Gabriela Ribeiro da Silva, Anderson Manoel Herculano, Dora Fix Ventura, Luiz Carlos Lima Silveira, Jan Kremers, Givago Silva Souza
Summary: This study investigated the amplitude and time course of pseudorandom ffERG during light adaptation. Results showed that different ffERG components had different mechanisms of adaptation to retinal light. The K-1 ffERG was influenced by retinal mechanisms with intermediate- to long-term light adaptation, while the K-2.1 ffERG was influenced by retinal mechanisms with a fast light adaptation course.
DOCUMENTA OPHTHALMOLOGICA
(2021)
Article
Neurosciences
Leonardo Miranda Feitosa, Camila Ferreira Alves, Natalia Ramalho Figueiredo, Wilker Leite Nascimento, Amanda Beatriz Adriano da Silva, Saulo Rivera Ikeda, Nadia Shigaeff, Caio Maximino, Monica Lima-Maximino
Summary: The Open Practical Laboratory in the Neurosciences is an outreach program aimed at improving elementary school students' knowledge of neuroscience and promoting positive attitudes toward science and scientists. The program was successful in enhancing students' understanding of neuroscience and fostering more favorable attitudes toward science.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Behavioral Sciences
Renan Idalencio, Taise Miranda Lopes, Suelen Mendonca Soares, Aline Pompermaier, Heloisa Helena de Alcantara Barcellos, Fabiana Kalichak, Michele Fagundes, Caio Maximino de Oliveira, Leonardo Jose Gil Barcellos
Summary: The dopaminergic system of zebrafish is complex and can be balanced by levodopa/carbidopa in regulating the stress response through action on the zebrafish hypothalamic-pituitary-adrenal (HPA) axis, specifically related to stress.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2021)
Article
Behavioral Sciences
Ana Flavia Nogueira Pimentel, Monica Gomes Lima-Maximino, Marta Candeias Soares, Caio Maximino
Summary: This study reveals that different fish species use a conditional approach strategy during predator inspection, displaying behaviors of cooperation, retaliation, and fear.
Article
Behavioral Sciences
Rhayra Xavier do Carmo Silva, Bianca Gomes do Nascimento, Gabriela Cristini Vidal Gomes, Nadyme Assad Holanda da Silva, Jessica Souza Pinheiro, Suianny Nayara da Silva Chaves, Ana Flavia Nogueira Pimentel, Bruna Patricia Dutra Costa, Anderson Manoel Herculano, Monica Lima-Maximino, Caio Maximino
Summary: The role of serotonin (5-HT) receptors in vertebrates in response to aversive stimuli remains unclear due to the existence of multiple specific receptors. Different aversive stimuli elicit responses at various threat levels, such as exploration, defensive behaviors, and freezing reactions. Exposure of adult zebrafish to a conspecific alarm substance showed that agnostic and antagonist of the 5-HT2C receptor had different effects on responses to different levels of threat.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Edinaldo Rogerio da Silva Moraes, Mateus Santos-Silva, Alan Araujo Grisolia, Danielle Valente Braga, Luana Ketlen Reis Leao, Carlomagno Pacheco Bahia, Suellen Alessa Soares de Moraes, Adelaide Fonseca Passos, Evander de Jesus Oliveira Batista, Anderson Manoel Herculano, Karen Renata Herculano Matos Oliveira
Summary: This study presents an alternative method for determining GAT activity in tissue preparations of the central nervous system using high performance liquid chromatography (HPLC) with fluorescence detection. The results demonstrate that this method provides a specific measure of GAT activity and validates the Na+- and temperature-dependent uptake of GABA.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Review
Public, Environmental & Occupational Health
Ketan Raymond Nair Brodeur, Anderson Herculano, Karen Oliveira
Summary: The discovery of malarial retinopathy is important for accurately diagnosing cerebral malaria. However, the lack of recognition by the World Health Organization has led to significant false-positive diagnoses. Raising awareness of malarial retinopathy can improve the accuracy of cerebral malaria diagnosis.
PATHOGENS AND GLOBAL HEALTH
(2023)
Article
Food Science & Technology
Tayana Silva de Carvalho, Alodia Brasil, Luana K. R. Ledo, Danielle Valente Braga, Mateus Santos-Silva, Nadyme Assad, Waldo Lucas Luz, Evander de Jesus O. Batista, Gilmara de Nazareth Tavares Bastos, Karen Renata Matos Herculano Oliveira, Domingos Luiz Wander ley Picanco Diniz, Anderson Manoel Herculano
Summary: An acal-enriched diet had no effect on body weight and food intake, but increased blood glucose levels after 31 days. In contrast, a similar fat-enriched diet led to weight gain and reduced food intake. The acal-enriched diet preserved motor performance, had anxiolytic effects, and improved memory retention in rats. Additionally, this diet reduced lipid peroxidation levels in the hippocampus.
FOOD & NUTRITION RESEARCH
(2022)
Article
Behavioral Sciences
Beatriz C. C. Saldanha, Paulo A. A. Silva, Caio Maximino, Goncalo C. Cardoso, Sandra Trigo, Marta C. C. Soares
Summary: Serotonin modulates the behavior of common waxbills through the 5-HT1A receptor pathway. The SSRI fluoxetine reduces aggression, activity, and feeding, while the other serotonergic enhancer (8-OH-DPAT) and the antagonist WAY 100,635 have no significant effect on behavior.
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Luana Carvalho Martins, Mateus dos Santos Silva, Emerson Feio Pinheiro, Luana Ketlen Reis Ledo da Penha, Adelaide da Conceicdo Fonseca Passos, Suellen Alessandra Soares de Moraes, Evander de Jesus Oliveira Batista, Anderson Manoel Herculano, Karen Renata Herculano Matos Oliveira
Summary: In this study, we investigated the activity of sodium-dependent and sodium-independent glutamate uptake mechanisms in primary cochlear glial cells cultures obtained from newborn Balb/C mice using High Performance Liquid Chromatography. Our results showed that sodium-independent glutamate transport has a significant contribution in cochlear glial cells, similar to other sensory organs, but not in tissues less susceptible to continuous glutamate-mediated injuries. The expression of the xCG- system in CGCs suggests its role in controlling extracellular glutamate concentrations and regulation of redox state to preserve auditory function.
Article
Pharmacology & Pharmacy
Edwiges de Fatima de Oliveira, Alodia Brasil, Anderson Manoel Herculano, Matheus A. Rosa, Bruno Duarte Gomes, Fernando Allan de Farias Rocha
Summary: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia, which can lead to microvascular damage in the retina causing diabetic retinopathy. This study aimed to evaluate the potential protective effect of acai on retinal function in mice with induced diabetes. The results showed that treatment with acai prevented a significant decrease in visual electrophysiological responses in diabetic animals.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychology, Biological
Bianca Gomes do Nascimento, Caio Maximino
Summary: Social preference tests are useful for analyzing variables that influence social behaviors and investigating the effects of substances. They can help find valid models for studying neuropsychiatric changes and impaired neurodevelopmental processes caused by social events.
BEHAVIOURAL PROCESSES
(2023)
Article
Integrative & Complementary Medicine
Karen Renata Herculano Matos Oliveira, Marjorie Lujan Marques Torres, Nayara Kauffmann, Brenda Jaqueline de Azevedo Ataide, Nivia de Souza Franco Mendes, Larissa Medeiros dos Anjos, Rosivaldo dos Santos Borges, Carlomagno Pacheco Bahia, Luana Ketlen Reis Leao, Adelaide da Conceicao Fonseca Passos, Anderson Manoel Herculano, Evander de Jesus Oliveira Batista
Summary: Diet enriched with acai can provide neuroprotection during the development of experimental cerebral malaria.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Multidisciplinary Sciences
Aurea Gabriela Rodrigues Mendes, Gabriel Gomes Vilar de Sousa, Martha de Souza Franca, Carlos Alberto Marques de Carvalho, Evander de Jesus Oliveira Batista, Adelaide da Conceicao Fonseca Passos, Karen Renata Herculano Matos Oliveira, Anderson Manoel Herculano, Suellen Alessandra Soares de Moraes
Summary: This study found that astrocyte reactivity in the spinal cord occurs during the acute phase of Achilles tendon repair, leading to impairment of mechanical sensitivity and gait, while only gait impairment remains in the chronic phase.
