Article
Neurosciences
Natalia Lopez-Gonzalez del Rey, Miguel Angel Garcia-Cabezas
Summary: This review article summarizes the developmental, cellular, structural, and connectional features of the primate striatum and relates them to patterns of neurodegeneration in humans and non-human primate models. By understanding the primate anatomy and its relation to human pathology, new insights into the molecular, cellular, and connectional factors underlying the degeneration of striatal neurons and circuits can be gained. The article provides an overview of the types of neurons, cyto-, myelo-, and chemoarchitecture, developmental origin, organization of corticostriatal projections, and the topography and time-course of neurodegenerative diseases in both humans and non-human primates.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Ellen T. Koch, Marja D. Sepers, Judy Cheng, Lynn A. Raymond
Summary: This study investigated the correlation between striatal activity and behavior in a Huntington's disease mouse model. Decreased striatal activity was observed during motor learning, with an inverse correlation between latency to fall and striatal activity. At an early stage, the YAC128 mice did not show a deficit in latency to fall but exhibited significant differences in paw kinematics and a weaker correlation between latency to fall and striatal activity. However, at 6 to 7 months, the YAC128 mice showed reduced latency to fall, impaired paw kinematics, and increased striatal activity. In the open field, elevated neuronal activity was observed at rest in the YAC128 mice.
MOVEMENT DISORDERS
(2022)
Article
Multidisciplinary Sciences
Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, C. Vigneswaran, Pragathi P. Balasubramani, Dhakshin S. Ramanathan, Jyoti Mishra, V. Srinivasa Chakravarthy
Summary: Human cognition encompasses various abilities such as selective attention, decision making, and working memory. In cognitive impairment research, it is crucial to study multiple cognitive functions simultaneously. Thus, we propose a unified, reinforcement learning-based agent model to simulate these cognitive tasks and map individual performance to model meta-parameters. This model has the potential to serve as a proxy for cognitively impaired conditions and as a clinical testbench for therapeutic interventions.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
James M. Shine
Summary: The human brain is a complex system, with the thalamus playing a crucial role in balancing integration and differentiation. Different thalamocortical connections may influence different information processing modes.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Elena Borra, Dalila Biancheri, Marianna Rizzo, Fabio Leonardi, Giuseppe Luppino
Summary: This study analyzed and compared the crossed corticostriatal (CSt) projections in the striatum of nonhuman primates. These projections are robust and mainly originate from motor, prefrontal, and cingulate areas. The findings provide the anatomical basis for the bilateral distribution of motor, motivational, and cognitive signals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jacqueline M. Ehrman, Paloma Merchan-Sala, Lisa A. Ehrman, Bin Chen, Hee-Woong Lim, Ronald R. Waclaw, Kenneth Campbell
Summary: The projection neurons of the striatum can be categorized into the striatopallidal (indirect) pathway or the striatonigral (direct) pathway. Striatonigral axons pioneer the internal capsule and cerebral peduncle and provide guidance for corticofugal and thalamocortical axons. Defects in the striatonigral pathway can disrupt internal capsule formation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ping C. Mamiya, Todd L. Richards, Richard A. E. Edden, Adrian K. C. Lee, Mark A. Stein, Patricia K. Kuhl
Summary: ADHD is associated with alterations in glutamate and GABA content in the brain circuitry responsible for attention control. This study found that individuals with ADHD showed smaller increases in Glx and GABA concentrations during attention control tasks compared to individuals without ADHD. Furthermore, smaller GABA increases in individuals with ADHD predicted poorer task performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Carlos Cepeda, Michael S. Levine
Summary: The understanding of the changes in cerebral cortex and basal ganglia in Huntington's disease has greatly improved with the help of genetic animal models. Recent studies have shown that synaptic dysfunction in the cortico-basal ganglia-cortical loop is influenced by cortical maldevelopment and disconnection in the corticostriatal pathway. Additionally, biphasic changes in glutamate and dopamine release in the striatum may explain the different symptoms in early and late stages of the disease.
Article
Neurosciences
Johannes Burtscher, Giuseppe Pepe, Federico Marracino, Luca Capocci, Susy Giova, Gregoire P. Millet, Alba Di Pardo, Vittorio Maglione
Summary: Huntington's disease (HD) is a rare hereditary neurodegenerative disorder characterized by defects in mitochondrial homeostasis and functions, including age-related changes in respiratory capacities. The study found differential expression of ETS components in the cortex and striatum of symptomatic R6/2 mice, indicating transcription, translation and/or mitochondrial import defects in R6/2 mouse brains.
Article
Biology
Eun Ju Shin, Yunsil Jang, Soyoun Kim, Hoseok Kim, Xinying Cai, Hyunjung Lee, Jung Hoon Sul, Sung-Hyun Lee, Yeonseung Chung, Daeyeol Lee, Min Whan Jung
Summary: Studies in rats, monkeys, and humans have found action-value signals encoded in various brain regions, which bias choices towards higher expected rewards. Statistical tests on neural activity in the striatum, frontal cortex, and hippocampus show that previously identified action-value signals cannot be solely explained by serial correlations or activity related to other decision variables. Additionally, it was found that neural activity related to action value is intertwined with signals related to other decision variables.
Article
Neurosciences
Kouichi C. Nakamura, Andrew Sharott, Takuma Tanaka, Peter J. Magill
Summary: In Parkinsonism, dopamine depletion leads to dysrhythmic activity in basal ganglia-recipient zone neurons, which differs from the normal neural cell activity and may affect brain information processing.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Yarden Cohen, Elad Schneidman, Rony Paz
Summary: The study found that neurons in the cingulate cortex mainly rotated towards the rule, while neurons in the putamen showed an increase in magnitude, indicating strengthening of confidence for the newly acquired rule-based policy. Additionally, neural representation at the end of a session predicted next-day behavior, reflecting overnight retention. The novel framework for characterization of neural dynamics suggests complementary roles for the putamen and the anterior cingulate cortex.
Article
Mathematics, Interdisciplinary Applications
Gayathri Vivekanandhan, Mahtab Mehrabbeik, Hayder Natiq, Nikhil Pal, Karthikeyan Rajagopal, Sajad Jafari
Summary: This paper investigates the contribution of basal ganglia regions in absence seizures and provides a detailed analysis of the basal ganglia cortex-thalamus (BGCT) model. The study finds that the BGCT model can exhibit chaotic behavior in small regions of the coupling parameter.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2023)
Article
Neurosciences
Joshua Barry, Minh T. N. Bui, Michael S. Levine, Carlos Cepeda
Summary: Huntington's disease is a heritable and fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene, leading to chorea and cognitive/psychiatric symptoms. Studies suggest that synaptic disconnection, particularly along excitatory pathways, is pervasive in HD, highlighting the critical role of the huntingtin protein in synaptic transmission.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Hsiao-Ying Kuo, Shih-Yun Chen, Rui-Chi Huang, Hiroshi Takahashi, Yen-Hui Lee, Hao-Yu Pang, Cheng-Hsi Wu, Ann M. Graybiel, Fu-Chin Liu
Summary: Kuo et al. have identified a mechanism by which the KE family mutation in FOXP2 can lead to childhood apraxia of speech. Using a mouse model, they found that the mutation disrupts the formation of vocalization circuits by inhibiting intracellular trafficking. This discovery sheds light on the genetic control of vocal communication in humans and could contribute to understanding speech disorders associated with FOXP2 mutations.
Article
Neurosciences
David Voyer, Daniel Levesque, Pierre-Paul Rompre
Article
Neurosciences
Alice Servonnet, Ellie-Anna Minogianis, Claude Bouchard, Anne-Marie Bedard, Daniel Levesque, Pierre-Paul Rompre, Anne-Noel Samaha
Article
Neurosciences
Florence Allain, David C. S. Roberts, Daniel Levesque, Anne-Noel Samaha
Article
Neurosciences
Catherine Levesque, Giovanni Hernandez, Souha Mahmoudi, Frederic Calon, Fabrizio Gasparini, Baltazar Gomez-Mancilla, Pierre J. Blanchet, Daniel Levesque
Article
Neurosciences
Sanjeev K. Bhardwaj, Fatema Dodat, Daniel Levesque, Lalit K. Srivastava
Article
Neurosciences
Claude Rouillard, Joanie Baillargeon, Brigitte Paquet, Michel St-Hilaire, Jerome Maheux, Catherine Levesque, Noemie Darlix, Simon Majeur, Daniel Levesque
EXPERIMENTAL NEUROLOGY
(2018)
Article
Neurosciences
Freddy Jeanneteau, Christian Barrere, Mariska Vos, Carlie J. M. De Vries, Claude Rouillard, Daniel Levesque, Yann Dromard, Marie-Pierre Moisan, Vanja Duric, Tina C. Franklin, Ronald S. Duman, David A. Lewis, Stephen D. Ginsberg, Margarita Arango-Lievano
JOURNAL OF NEUROSCIENCE
(2018)
Editorial Material
Clinical Neurology
Pierre J. Blanchet, Daniel Levesque
MOVEMENT DISORDERS
(2020)
Article
Behavioral Sciences
Marc Fakhoury, Giovanni Hernandez, Daniel Levesque, Pierre-Paul Rompre
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Mathematics, Applied
Florence Veronneau-Veilleux, Mauro Ursino, Philippe Robaey, Daniel Levesque, Fahima Nekka
Article
Biochemistry & Molecular Biology
David Voyer, Juergen Einsiedel, Peter Gmeiner, Daniel Levesque, Pierre-Paul Rompre
Summary: This study confirmed that neurotensin stimulates locomotor activity and initiates neural changes through Ntsr2 receptor subtypes, leading to amphetamine-induced sensitization.
Article
Biochemistry & Molecular Biology
Fatema Dodat, David Cotnoir-White, Elham Dianati, Amandine Vallet, Sylvie Mader, Daniel Levesque
Summary: Nur77, a nuclear receptor in the Nr4a family, regulates various cellular functions and metabolism. PIAS gamma and SUMO2 were identified as important transcriptional co-regulators of Nur77, with K102 and K577 sites playing a crucial role in modulating its activity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fatema Dodat, Sylvie Mader, Daniel Levesque
Summary: NR4A receptors form a family of nuclear receptors that regulate various physiological and pathological processes as transcription factors. The physiological functions of NR4A family members are influenced by post-translational modifications such as SUMOylation.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Neurosciences
Alice Servonnet, Florence Allain, Alice Gravel-Chouinard, Giovanni Hernandez, Casey Bourdeau Caporuscio, Mathilde Legrix, Daniel Levesque, Pierre-Paul Rompre, Anne-Noel Samaha
Summary: Antipsychotic treatment can induce dopamine supersensitivity in rats, leading to an enhanced response to D-amphetamine. After cessation of treatment, rats exhibit a supersensitive psychomotor response to the D2 agonist quinpirole, while D1 agonists and a dopamine reuptake blocker do not have the same effect.
Article
Neurosciences
Cynthia Kwan, Catherine Levesque, Dominique Bedard, Imane Frouni, Jemal M. Yesuf, Adjia Hamadjida, Daniel Levesque, Paul Bs Clarke, Philippe Huot
Summary: Serotonin type 3 antagonists can alleviate dyskinesia induced by L-DOPA and enhance its anti-parkinsonian action. The results suggest that alterations in 5-HT3 mediated neurotransmission may contribute to the pathophysiology of L-DOPA induced dyskinesia.
NEUROSCIENCE RESEARCH
(2022)