Article
Biology
Hiroki Tanaka, Kuniyuki Nishina, Qiulu Shou, Hidehiko Takahashi, Masamichi Sakagami, Tetsuya Matsuda, Miho Inoue-Murayama, Haruto Takagishi
Summary: This study shows the association between genetic mutations in three genes associated with human sociality and individuals' aversion to inequity. The participants took part in five economic game experiments and their behavioral responses were used to calculate the level of disadvantageous inequity aversion and advantageous inequity aversion. The study found that there was an association between the AVPR1A gene mutation and advantageous inequity aversion, suggesting the important role of AVPR1A in aversion when individuals' gain is greater than that of others.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Jack H. Taylor, Noah S. Campbell, Jeanne M. Powell, H. Elliott Albers, Aubrey M. Kelly
Summary: The nonapeptide system plays a crucial role in regulating various social behaviors in different species. This study maps the distribution of oxytocin and vasopressin receptors in the brain of male and female Mongolian gerbils and explores the influence of gonadal sex on these receptors. The findings provide a foundation for future research on manipulating the nonapeptide system to study social behavior.
Article
Neurosciences
Vinicius E. de M. Oliveira, Trynke R. de Jong, Inga D. Neumann
Summary: Exacerbated aggression is a core symptom of several psychiatric disorders and can also affect women. Despite increasing evidence for sex-specificity, little is known about aggression in females. This study investigated the role of the oxytocin and arginine vasopressin systems in the central amygdala on aggressive behavior in female rats. The findings suggest that the central amygdala plays a moderate role in female aggression, and synthetic oxytocin and arginine vasopressin modulate aggressive behavior in female rats.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Viviane Felintro, Veronica Trujillo, Raoni C. dos-Santos, Claudio da Silva-Almeida, Luis C. Reis, Fabio F. Rocha, Andre S. Mecawi
Summary: Vasopressin and oxytocin are important neuropeptides that help mammals defend against dehydration. Recent studies have shown that they also play a role in modulating behavioral responses through connections with limbic structures. However, the upregulation of oxytocin receptor expression in the central amygdala after 48-hour water deprivation does not seem to mediate the hypoactivity response observed in rats.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Anatomy & Morphology
Jeanne M. Powell, Kiyoshi Inoue, Kelly J. Wallace, Ashley W. Seifert, Larry J. Young, Aubrey M. Kelly
Summary: The nonapeptide system, through the activation of oxytocin and vasopressin receptors, modulates various social behaviors. This study mapped the distribution and expression of OXTR and AVPR1A receptors in the spiny mouse brain and found differences between males and females in the binding densities and co-expression patterns in brain regions involved in social behavior and reward. These findings provide important insights for studying nonapeptide-mediated behavior in a highly social species.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biology
Kengo Inada, Kazoku Tsujimoto, Masahide Yoshida, Katsuhiko Nishimori, Kazunari Miyamichi
Summary: Studies have shown that oxytocin signaling in the arcuate nucleus suppresses excessive food intake, playing an important role in body weight homeostasis and appetite regulation.
Review
Endocrinology & Metabolism
Haiyan Zheng, Ji Yeon Lim, Yerin Kim, Sang Taek Jung, Sun Wook Hwang
Summary: Oxytocin and vasopressin, neurohypophyseal hormones, play a central role in regulating bodily homeostasis and are strongly involved in downregulating pain. By modulating nociceptors, the first component of the pain signaling pathway, these peptides contribute to pain attenuation, sparking scientific interest in their physiological processes.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miguel A. Ortega, Cielo Garcia-Montero, Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego Liviu Boaru, Coral Bravo, Juan A. De Leon-Luis, Miguel A. Saez, Angel Asunsolo, Ignacio Romero-Gerechter, Alejandro Sanz-Giancola, Raul Diaz-Pedrero, Laura Lopez-Gonzalez, Luis G. Guijarro, Silvestra Barrena-Blazquez, Julia Bujan, Natalio Garcia-Honduvilla, Melchor Alvarez-Mon, Miguel Angel Alvarez-Mon, Guillermo Lahera
Summary: Psychosis is a mental health condition characterized by a loss of touch with reality. A first-episode psychosis during pregnancy can have adverse effects on both the mother and newborn. This study aimed to analyze the gene and protein expression of oxytocin (OXT), oxytocin receptor (OXTR), vasopressin (AVP), and vasopressin receptor 1a (AVPR1a) in the placental tissue of pregnant women after a first-episode psychosis. The results showed increased gene and protein expression of OXT, AVP, OXTR, and AVPR1A in the placental tissue of these women. This suggests that an abnormal paracrine/endocrine activity of the placenta may be associated with a first-episode psychosis during pregnancy, negatively impacting the well-being of both the mother and fetus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hannah S. Ballas, Samantha M. Wilfur, Nicole A. Freker, Kah-Chung Leong
Summary: Factors such as stress and anxiety can trigger alcohol-dependent behavior and relapse, and investigating potential pharmacological interventions is important. Previous studies suggest that oxytocin has anxiolytic potential and can disrupt stress-induced ethanol-seeking behavior, specifically within the central amygdala.
Article
Multidisciplinary Sciences
Vinicius Elias de Moura Oliveira, Michael Lukas, Hannah Nora Wolf, Elisa Durante, Alexandra Lorenz, Anna-Lena Mayer, Anna Bludau, Oliver J. Bosch, Valery Grinevich, Veronica Egger, Trynke R. de Jong, Inga D. Neumann
Summary: This study establishes a model of enhanced aggression in virgin female rats and shows that oxytocin and vasopressin systems differentially modulate aggression in distinct neuronal populations of the lateral septum of female rats.
NATURE COMMUNICATIONS
(2021)
Article
Health Care Sciences & Services
Hilda T. Maibach, Michael J. Brownstein, Steven M. Hersch, Karen E. Anderson, Debra E. Itzkowitz, Eve M. Damiano, Neal G. Simon
Summary: SRX246, an orally available V1a receptor antagonist, was found to reduce aggressive behavior in HD patients and was well tolerated.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Clinical
Juan Kou, Yingying Zhang, Feng Zhou, Cornelia Sindermann, Christian Montag, Benjamin Becker, Keith M. Kendrick
Summary: Acute and chronic intranasal oxytocin administration have different effects on the amygdala, with infrequent chronic use showing the most therapeutic efficacy and genotype-dependent anxiety attenuation.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Aysu Sen, Ali Yucel Kara, Ahmet Koyu, Fatma Simsek, Servet Kizildag, Nazan Uysal
Summary: Chronic restraint stress did not significantly affect empathy-like behaviour in rats, but was found to increase vasopressin levels in the amygdala, leading to higher adrenal glands relative weights and apoptotic cell ratios. Histopathological changes were detected despite no significant differences in behavioral tests. Further research into different stress applications, gender-related changes, and other neurochemical pathways related to stress and empathy is recommended.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Walter Francesconi, Fulvia Berton, Valentina Olivera-Pasilio, Joanna Dabrowska
Summary: The study reveals that oxytocin has distinct effects on different types of neurons in the dorsolateral bed nucleus of the stria terminalis. It selectively excites some neurons while inhibiting others, potentially facilitating conditioned fear by suppressing inter-neuronal interactions.
Review
Endocrinology & Metabolism
D. Grassi, M. Marraudino, L. M. Garcia-Segura, G. C. Panzica
Summary: This article reviews the roles of estradiol and hypothalamic paraventricular nucleus (PVN) in coordinating reproduction, body physiology, growth, and metabolism. The authors discuss the cyto- and chemo-architecture, connectivity, and function of PVN, as well as the sex-specific regulation exerted by estradiol on PVN neurons and the expression of neurotransmitters, neuromodulators, neuropeptides, and neurohormones in PVN. The study also highlights the importance of classical and non-classical estrogen receptors (ERs) in modulating body homeostasis through PVN.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Heon-Jin Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Dentistry, Oral Surgery & Medicine
Yong-Gun Kim, Myoung Ok Kim, Sung-Hyun Kim, Hyo Jeong Kim, Nitin Kumar Pokhrel, Ji Hye Lee, Heon-Jin Lee, Jae-Young Kim, Youngkyun Lee
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Medicine, General & Internal
Su Young Oh, Sung-Min Kang, Soo Hyun Kang, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Sung-Tak Lee, So-Young Choi, Su-Hyung Hong
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Medicine, Research & Experimental
Heon-Jin Lee
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Neurosciences
Adi Cymerblit-Sabba, Adam S. Smith, Sarah K. Williams Avram, Michelle Stackmann, Austin C. Korgan, Maria C. Tickerhoof, W. Scott Young
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Neurosciences
W. Scott Young, June Song
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Environmental Sciences
Se-Won Park, Ra Gyoung Yoon, Hyunwoo Lee, Heon-Jin Lee, Yong-Do Choi, Du-Hyeong Lee
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Letter
Endocrinology & Metabolism
Balazs Mayer, Krisztian Nemeth, Miklos Krepuska, Vamsee D. Myneni, Dragan Maric, John F. Tisdale, Matthew M. Hsieh, Naoya Uchida, Heon-Jin Lee, Michael J. Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildiko Szalayova, Jerome Pagani, Karoly Marko, Ian MacClain-Caldwell, Lynn Vitale-Cross, W. Scott Young, Michael J. Brownstein, Eva Mezey
CLINICAL ENDOCRINOLOGY
(2021)
Article
Neurosciences
Jerome Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stephanie Goyon, Daisuke Hagiwara, Arthur Lefevre, Lara Barteczko, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Da Silva Gouveia, Diego Benusiglio, Marina Eliava, Andrei Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Matthew K. Kirchner, Ranjan K. Roy, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudia Pitzer, Jan Siemens, Yannick Goumon, Benjamin Boutrel, Christophe Maurice Lamy, Isabelle Decosterd, Jean-Yves Chatton, Nathalie Rouach, W. Scott Young, Javier E. Stern, Pierrick Poisbeau, Ron Stoop, Pascal Darbon, Valery Grinevich, Alexandre Charlet
Summary: This study reveals a morphologically distinct subpopulation of astrocytes expressing OT receptors in the central amygdala of mice and rats, mediating the anxiolytic and positive reinforcement effects of OT. It challenges the traditional belief that OT exclusively acts on neurons, highlighting the essential role of astrocytes in modulating emotional states under normal and chronic pain conditions.
NATURE NEUROSCIENCE
(2021)
Article
Oncology
Soo Hyun Kang, Su Young Oh, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Sung-Tak Lee, So-Young Choi, Su-Hyung Hong
Summary: Fibroblasts are a heterogeneous population of cells that play a role in cancer progression. CAFs from HNSCC patients may delay cancer progression through specific collagen proteins.
Article
Biochemistry & Molecular Biology
So-Young Choi, Soo Hyun Kang, Su Young Oh, Kah Young Lee, Heon-Jin Lee, Sangil Gum, Tae-Geon Kwon, Jin-Wook Kim, Sung-Tak Lee, Yoo Jin Hong, Dae-Geon Kim, Su-Hyung Hong
Summary: The study characterized mouse tumors derived from 2D and 3D cells to establish an in vivo model with standardized conditions. Results showed that tumors were formed when cells and spheroids co-injected with primary CAFs, with spheroid-derived tumors having abundant vasculature. Cisplatin injection significantly decreased spheroid-derived tumor size, and exosomes from spheroid and CAF co-culture media upregulated angiogenesis-related genes in HNSCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yousuke Tsuneoka, Chihiro Yoshihara, Ryuko Ohnishi, Sachine Yoshida, Eri Miyazawa, Masanobu Yamada, Kazuhiko Horiguchi, W. Scott Young, Katsuhiko Nishimori, Tadafumi Kato, Kumi O. Kuroda
Summary: The study illustrates the relationship between oxytocin and parental care, genetic mutations can affect parental behaviors in mice, and the behavior performance towards pups showed no significant difference among mice with different genotypes under minimal stress conditions.
Article
Biochemistry & Molecular Biology
Song-Yi Choi, Su-Hyung Hong, Heon-Jin Lee
Summary: This study analyzed exosomal miRNA sequencing data from PMA-treated U937 cells and found that miR-24 was highly expressed in exosomes and associated with alpha-tubulin and hnRNP-E1 proteins. Inactivating these proteins resulted in a significant reduction of exosomal miR-24. The findings suggest that miR-24 is transported into exosomes from activated macrophages with the support of alpha-tubulin and hnRNP-E1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Su-Im Kim, Jae Yeong Ha, Song-Yi Choi, Su-Hyung Hong, Heon-Jin Lee
Summary: Extracellular vesicles, including bacterial vesicles, can be used as vehicles for delivering genetic materials, such as genes and RNA, into recipient cells. This study demonstrated the successful delivery of GFP genes and precursor microRNA into murine microglial cells using bacterial vesicles.
Article
Microbiology
Jae Yeong Ha, Jiwon Seok, Suk-Jeong Kim, Hye-Jin Jung, Ka-Young Ryu, Michiko Nakamura, Il-Sung Jang, Su-Hyung Hong, Youngkyun Lee, Heon-Jin Lee
Summary: EVs secreted by periodontopathogens such as Aa may contribute to the pathogenesis of neuroinflammatory diseases by inducing the release of proinflammatory cytokines through the TLR signaling pathway. Moreover, EVs can directly activate neuronal inflammation signals through retrograde axonal transport and alter the action potential of neurons.