Article
Neurosciences
Melissa A. Tapia, Xiao-Tao Jin, Brenton R. Tucker, Leanne N. Thomas, Noah B. Walker, Veronica J. Kim, Steven E. Albertson, Naresh Damuka, Ivan Krizan, Seby Edassery, Jeffrey N. Savas, Kiran Kumar Solingapuram Sai, Sara R. Jones, Ryan M. Drenan
Summary: This study investigated the behavior and neurobiological effects of intermittent nicotine intake in rats. The results suggest that intermittent nicotine intake may lead to increased craving and enhanced response to nicotine-associated cues. Additionally, intermittent nicotine intake also caused increased nicotine binding in the brain and specific changes in the proteome of certain neural structures.
Review
Health Care Sciences & Services
Merel Keijsers, Maria Cecilia Vega-Corredor, Melanie Tomintz, Simon Hoermann
Summary: Virtual reality technologies have been proposed to enhance smoking cessation therapy, with cue exposure therapy being the most studied intervention. However, the long-term effects are inconsistent. Behavioral therapies like approach-avoidance tasks or gamified interventions have shown positive results.Future research should focus on multicomponent interventions and include control groups for validity.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Genetics & Heredity
Ahmet Muderrisoglu, Elif Babaoglu, Elif Tugce Korkmaz, Said Kalkisim, Erdem Karabulut, Salih Emri, Melih O. Babaoglu
Summary: In this study, smoking cessation treatment with varenicline was significantly more effective than treatments with nicotine replacement therapy or bupropion in Turkish subjects. Regardless of carrying wild-type or variant alleles, subjects with human nicotinic acetylcholine receptor subunits alpha 3, alpha 4, and alpha 5 showed similar clinical outcomes and smoker/non-smoker status in response to pharmacological treatments.
FRONTIERS IN GENETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yang Du, Kuan Yang, Zhifei Zhou, Lizheng Wu, Lulu Wang, Yujiang Chen, Xin Ge, Xiaojing Wang
Summary: Nicotine regulates autophagy of human periodontal ligament cells (hPDLCs) through alpha 7 nAChR, which further regulates the release of inflammatory factors IL-1 beta and IL-8 from hPDLCs.
Article
Cell Biology
Irida Papapostolou, Daniela Ross-Kaschitza, Florian Bochen, Christine Peinelt, Maria Constanza Maldifassi
Summary: Nicotine in tobacco induces tumor-promoting effects and chemotherapy resistance through nicotinic acetylcholine receptors (nAChRs). This study investigates the role of a5 subunit in nicotine-induced cancer cell proliferation and migration in breast, colon, and prostate cancer cells. The results show that nicotine-induced proliferation and migration are mediated by a5.
Article
Environmental Sciences
Hui-yi Yan, Xiao Wen, Lan-zhou Chen, Yi-ting Feng, Han-xiao Liu, Wen Qu, Wen-hao Zhao, Dong-qin Xu, Jie Ping
Summary: Our study revealed that nicotine suppressed the development pathway of CD4(+)SP cells by inducing autophagy, shedding light on the developmental origin mechanism of programmed immune diseases in PNE offspring.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Neurosciences
Yanping Zhang, Alec Sevilla, Robert Weller, Shuju Wang, Melvin C. Gitlin, Keith A. Candiotti
Summary: This study found that chronic nicotine administration induces hypersensitivity to mechanical stimuli and decreases the pain perception threshold. Nicotine can alter the expression levels of alpha 7-nAChR in the brain and spinal cord, and selective agonists can reverse this hypersensitivity. Additionally, chronic nicotine administration leads to an increase in microglial cells and inflammatory factors in the spinal cord, potentially contributing to chronic pain.
NEUROSCIENCE LETTERS
(2021)
Article
Clinical Neurology
Shuochi Wei, Dongmei Wang, Huixia Zhou, Luyao Xia, Yang Tian, Qilong Dai, Rongrong Zhu, Wenjia Wang, Dachun Chen, Meihong Xiu, Li Wang, Xiangyang Zhang
Summary: This study compared the clinical characteristics and cognitive symptoms between heavy smoking and non-heavy smoking groups in Chinese male patients with schizophrenia. The findings showed significant differences between the two groups, with heavy smokers being younger, starting smoking earlier, and having a higher degree of nicotine dependence. Heavy smokers also had lower negative symptom scores and cognitive factor scores.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Afework Tsegaye, Cuiling Guo, Renata Cserjesi, Leon Kenemans, Gijsbert Stoet, Gyongyi Kokonyei, Alexander Logemann
Summary: The study found that smokers showed reduced inhibitory control in contexts of reward, leading to faster response times, indicating an enhanced approach bias to reward-related stimuli. This suggests that smokers may have difficulty in controlling their impulses in rewarding situations, possibly due to heightened sensitivity to rewards.
BEHAVIORAL SCIENCES
(2021)
Review
Psychiatry
Sofoa Pinho, Vania Rocha, Maria A. Vieira-Coelho
Summary: Multimodal smoking cessation interventions are effective in reducing smoking rates among patients with schizophrenia without worsening psychiatric symptoms. Additional studies are needed to improve long-term smoking abstinence outcomes.
SCHIZOPHRENIA RESEARCH
(2021)
Review
Neurosciences
Alan F. Sved, Jillian J. Weeks, Anthony A. Grace, Tracy T. Smith, Eric C. Donny
Summary: Cigarette smoking reduces MAO activity, enhancing the addictive properties of nicotine. Low-dose nicotine self-administration is increased by MAO inhibition. The impact of MAO inhibition should be considered in VLNC cigarettes and tobacco product regulation, especially in vulnerable populations with nicotine addiction.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Vaibhav Upadhyay, Peter J. Turnbaugh
Summary: The metabolism of nicotine by gut bacteria plays a significant role in protecting against liver disease.
Article
Neurosciences
Hannah J. Zhang, Matthew Zammit, Chien-Min Kao, Anitha P. Govind, Samuel Mitchell, Nathanial Holderman, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Xiaoxi Zhuang, Jogeshwar Mukherjee, Chin-Tu Chen, William N. Green
Summary: The distribution of nicotine and other nicotinic receptor ligands in the brain is investigated. Ligands with high pKa and affinity for cc4P2Rs, like varenicline, are trapped in intracellular acidic vesicles in vitro, while nicotine, with lower pKa and affinity, is not trapped. In vivo imaging of PET ligands in mouse brain reveals that the trapping organelle is Golgi satellites (GSats) and provides insights into the subcellular distribution of these ligands.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Qiang Li, Jingtan Li, Jingting Wang, Jing Wang, Tong Lu, Yanfei Jia, Haiji Sun, Xiaoli Ma
Summary: Evidence has shown a strong relationship between smoking and epithelial mesenchymal transition (EMT) in lung adenocarcinoma (LUAD). This study identifies a novel pathway involving alpha 5-nicotinic acetylcholine receptor (alpha 5-nAChR), PLEK2, and CFL1 in nicotine-induced LUAD progression. The alpha 5-nAChR/PLEK2/CFL1 pathway contributes to cell migration, invasion, and stemness in LUAD.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Andres Rodriguez-Vega, Ana Carolina Dutra-Tavares, Thaina P. Souza, Keila A. Semeao, Claudio C. Filgueiras, Anderson Ribeiro-Carvalho, Alex C. Manhaes, Yael Abreu-Villaca
Summary: Tobacco misuse as a comorbidity of schizophrenia during adolescence was studied using label-free proteomics in mice. Deregulated proteins were identified in the prefrontal cortex of mice with a history of nicotine exposure. The study sheds light on the understanding of schizophrenia and nicotine comorbidity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Isabelle A. Birt, Megan H. Hagenauer, Sarah M. Clinton, Cigdem Aydin, Peter Blandino, John D. H. Stead, Kathryn L. Hilde, Fan Meng, Robert C. Thompson, Huzefa Khalil, Alex Stefanov, Pamela Maras, Zhifeng Zhou, Elaine K. Hebda-Bauer, David Goldman, Stanley J. Watson, Huda Akil
Summary: By studying gene expression in the hippocampus of rats with high and low exploratory activity, candidate genes associated with metabolism, mood, and neurodevelopment were identified, suggesting divergent developmental trajectories and different reactions to the environment in bHR and bLR rats.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Falk W. Lohoff, Arunima Roy, Jeesun Jung, Martha Longley, Daniel B. Rosoff, Audrey Luo, Emma O'Connell, Jill L. Sorcher, Hui Sun, Melanie Schwandt, Colin A. Hodgkinson, David Goldman, Reza Momenan, Andrew M. McIntosh, Mark J. Adams, Rosie M. Walker, Kathryn L. Evans, David Porteous, Alicia K. Smith, Jisoo Lee, Christine Muench, Katrin Charlet, Toni-Kim Clarke, Zachary A. Kaminsky
Summary: The study identified differential methylation in glucocorticoid signaling and inflammation-related genes associated with alcohol use behaviors. Investigation of the GAS5 gene revealed its multiple functions related to glucocorticoid receptor transcriptional activity, cell apoptosis, and immune function.
MOLECULAR PSYCHIATRY
(2021)
Article
Substance Abuse
Wenfei Huang, Heping Zhou, Colin Hodgkinson, Angelo Montero, David Goldman, Sulie L. Chang
Summary: The study found that ethanol exposure may enhance inflammation induced by SARS-CoV-2 by altering the activity of key inflammatory mediators. The research suggests the importance of clinicians cautioning patients about the risk of alcohol consumption during the COVID-19 pandemic, and calls for further exploration into how alcohol exposure affects viral infections.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Neurosciences
Elizabeth K. Wood, Ryno Kruger, Jaclyn P. Day, Stephen M. Day, Jacob N. Hunter, Leslie Neville, Stephen G. Lindell, Christina S. Barr, Melanie L. Schwandt, David Goldman, Stephen J. Suomi, James C. Harris, J. Dee Higley
Summary: Research on rhesus macaques suggests that early parental neglect and variation in the serotonin transporter genotype could play a role in the etiology of NSSI. NSSI subjects with different 5-HTT genotypes exhibited distinct behaviors, highlighting the complexity of NSSI typologies.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Danielle S. Kroll, Katherine L. McPherson, Peter Manza, Melanie L. Schwandt, Pei-Hong Shen, David Goldman, Nancy Diazgranados, Gene-Jack Wang, Corinde E. Wiers, Nora D. Volkow
Summary: This study found that individuals with alcohol use disorder (AUD) had higher serum transferrin saturation compared to healthy controls. The genetic variation in HFE rs1799945 was associated with elevated transferrin saturation in both AUD and healthy controls. Serum transferrin saturation can predict alcohol withdrawal severity, suggesting its potential use as a predictor for treatment.
Article
Gastroenterology & Hepatology
John B. Whitfield, Tae-Hwi Schwantes-An, Rebecca Darlay, Guruprasad P. Aithal, Stephen R. Atkinson, Ramon Bataller, Greg Botwin, Naga P. Chalasani, Heather J. Cordell, Ann K. Daly, Christopher P. Day, Florian Eyer, Tatiana Foroud, Dermot Gleeson, David Goldman, Paul S. Haber, Jean-Marc Jacquet, Tiebing Liang, Suthat Liangpunsakul, Steven Masson, Philippe Mathurin, Romain Moirand, Andrew McQuillin, Christophe Moreno, Marsha Y. Morgan, Sebastian Mueller, Beat Muellhaupt, Laura E. Nagy, Pierre Nahon, Bertrand Nalpas, Sylvie Naveau, Pascal Perney, Munir Pirmohamed, Helmut K. Seitz, Michael Soyka, Felix Stickel, Andrew Thompson, Mark R. Thursz, Eric Trepo, Timothy R. Morgan, Devanshi Seth
Summary: This study developed a genetic risk score that can identify individuals at high risk of developing cirrhosis. It was found that the risk of cirrhosis is increased over 10-fold in patients with diabetes and a high genetic risk score. This risk assessment could lead to early and personalized management of the disease in high-risk patients.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haitao Zhang, Bridget F. Grant, Colin A. Hodgkinson, W. June Ruan, Bradley T. Kerridge, Boji Huang, Tulshi D. Saha, Amy Z. Fan, Veronica Wilson, Jeesun Jung, Abbas Parsian, David Goldman, S. Patricia Chou
Summary: The study indicates that substance use disorders (SUDs) are partially heritable and are cross-transmitted genetically. Using exome-focused genotyping, researchers identified susceptibility genes for SUDs that overlap significantly with genes previously implicated by GWAS studies. Polygenic scores revealed shared and unshared genetic contributions to the pathogenesis of SUDs, as well as differences in the inheritance patterns among different SUDs.
MOLECULAR PSYCHIATRY
(2022)
Article
Microbiology
J. J. Barb, K. A. Maki, N. Kazmi, B. K. Meeks, M. Krumlauf, R. T. Tuason, A. T. Brooks, N. J. Ames, D. Goldman, G. R. Wallen
Summary: This study investigated the effects of alcohol cessation on the oral microbiome during inpatient treatment for alcohol use disorder (AUD). The results showed that alcohol preference was associated with changes in oral microbiome diversity, and alcohol cessation and attention to oral care improved dysbiosis and oral health.
JOURNAL OF ORAL MICROBIOLOGY
(2022)
Article
Psychiatry
Caline S. Karam, Brenna L. Williams, Irina Morozova, Qiaoping Yuan, Rony Panarsky, Yuchao Zhang, Colin A. Hodgkinson, David Goldman, Sergey Kalachikov, Jonathan A. Javitch
Summary: Drug abuse, particularly of stimulants, is a significant public health issue with various complications. This study utilized the fruit fly model to investigate the transcriptional changes induced by amphetamines (AMPHs), identifying genes involved in mRNA translation control that were upregulated in response to AMPH. The findings contribute to our understanding of the molecular basis of drug addiction.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Jacob N. N. Hunter, Elizabeth K. K. Wood, Brandon L. L. Roberg, Leslie Neville, Melanie L. L. Schwandt, Lynn A. A. Fairbanks, Christina Barr, Stephen G. G. Lindell, David Goldman, Stephen J. J. Suomi, J. Dee Higley
Summary: This study examines the differences in rates of aggression exhibited by male and female rhesus monkeys in the presence of an unfamiliar stranger. The results suggest that males display higher rates of physical aggression towards the stranger, particularly when both the resident and stranger possess the s-allele of the 5-HTT genotype. Interestingly, resident females also exhibit higher rates of physical aggression, but towards familiar same-sex members of their social group.
HORMONES AND BEHAVIOR
(2022)
Correction
Gastroenterology & Hepatology
John B. Whitfield, Tae-Hwi Schwantes-An, Rebecca Darlay, Guruprasad P. Aithal, Stephen R. Atkinson, Ramon Bataller, Greg Botwin, Naga P. Chalasani, Heather J. Cordell, Ann K. Daly, Christopher P. Day, Florian Eyer, Tatiana Foroud, Dermot Gleeson, David Goldman, Paul S. Haber, Jean-Marc Jacquet, Tiebing Liang, Suthat Liangpunsakul, Steven Masson, Philippe Mathurin, Romain Moirand, Andrew McQuillin, Christophe Moreno, Marsha Y. Morgan, Sebastian Mueller, Beat Muellhaupt, Laura E. Nagy, Pierre Nahon, Bertrand Nalpas, Sylvie Naveau, Pascal Perney, Munir Pirmohamed, Helmut K. Seitz, Michael Soyka, Felix Stickel, Andrew Thompson, Mark R. Thursz, Eric Trepo, Timothy R. Morgan, Devanshi Seth
JOURNAL OF HEPATOLOGY
(2022)
Article
Neurosciences
Jeesun Jung, Daniel L. McCartney, Josephin Wagner, Joyce Yoo, Andrew S. Bell, Lucas A. Mavromatis, Daniel B. Rosoff, Colin A. Hodgkinson, Hui Sun, Melanie Schwandt, Nancy Diazgranados, Alicia K. Smith, Vasiliki Michopoulos, Abigail Powers, Jennifer Stevens, Bekh Bradley, Negar Fani, Rosie M. Walker, Archie Campbell, David J. Porteous, Andrew M. McIntosh, Steve Horvath, Riccardo E. Marioni, Kathryn L. Evans, David Goldman, Falk W. Lohoff
Summary: The relationships between stress, alcohol use disorder (AUD), and premature aging are not well understood. A study found that using composite scores and DNA methylation markers to measure the impact of stress and alcohol consumption on aging can offer new insights into the pathophysiology of premature aging in AUD.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Zhifeng Zhou, Pamela Metten, Qiaoping Yuan, Hui Sun, Colin A. Hodgkinson, Pei-Hong Shen, Cheryl Marietta, John C. Crabbe, David Goldman
Summary: This study identified a polygenic network and neural signaling pathways contributing to ethanol withdrawal seizures and related phenotypes, which overlap with genes modulating epilepsy and neuronal excitability, through multi-omic analysis of mouse lines and human subjects.
MOLECULAR PSYCHIATRY
(2022)