Article
Behavioral Sciences
Lucas T. Laudermilk, Kathryn M. Harper, Sheryl S. Moy, Scott Runyon, Bin Zhou, Beverly Koller, Rangan Maitra
Summary: The G-protein-coupled receptor APLNR, along with its ligands apelin and ELABELA/TODDLER/apela, form the apelinergic system crucial for development and physiological balance, potentially offering treatment for heart failure, pulmonary arterial hypertension, and metabolic syndrome. While widely present in the central nervous system, its exact role remains unclear. Knockout of the Aplnr gene in mice showed significant impacts on sensory responses and fear behaviors, especially in male mice displaying heightened fear responses.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Congyao Zha, Karine Gamache, Oliver M. Hardt, Wayne S. Sossin
Summary: CAPN15 is an intracellular cysteine protease that plays an important role in development. Loss of CAPN15 leads to eye anomalies and brain volumetric changes in mice, and biallelic variants in CAPN15 are associated with developmental delay and neurodevelopmental disorders in humans. In this study, it was found that CAPN15 regulates behavior in adult mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Medicine, General & Internal
Wenlong Zhang, Jie Huang, Feng Gao, Qianglong You, Liuyan Ding, Junwei Gong, Mengran Zhang, Runfang Ma, Shaohui Zheng, Xiangdong Sun, Yunlong Zhang
Summary: The study reveals that Cntnap4 deficiency leads to social behavior and fear memory deficits in mice. Reduced GABAergic transmission was observed in the amygdala of Cntnap4-/- mice. Microbiota supplementation through Lactobacillus treatment or faecal transplantation can improve fear memory abnormalities caused by Cntnap4 deficiency.
Article
Biochemistry & Molecular Biology
Sarayut Phasuk, Peeraporn Varinthra, Andaman Nitjapol, Korakod Bandasak, Ingrid Y. Liu
Summary: Research suggests that PRDX6 levels are downregulated in response to acute stress, impacting memory performance, and Prdx6(-/-) mice exhibit increased anxiety behavior and memory deficits under stress.
Article
Biology
Austin M. Adkins, Laurie L. Wellman, Larry D. Sanford
Summary: Stress can induce neuroinflammation and disrupt sleep, and fear memories can resurface and reproduce symptoms. The controllability of stress can alter neuroinflammatory signaling and its association with sleep following fear memory recall.
Article
Biology
Weiwei Liu, Yan Cao, Yue Lin, Keai Sinn Tan, Haishan Zhao, Haihua Guo, Wen Tan
Summary: The study found that inhibition of BChE improved episodic and spatial memories. It also suggested the potential application of (R)-bambuterol as a BChE inhibitor in the treatment of post-traumatic stress disorder (PTSD) and early cognitive decline.
Article
Clinical Neurology
Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Comai
Summary: Deletion of Syns in mice results in behavioral abnormalities and neurobiological changes, including hyperactivity, social impairment, anxiety-like behavior, reduced firing activity of DRN 5-HT neurons, enhanced responsiveness of DRN 5-HT-1A autoreceptors, and lower hippocampal 5-HT levels.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomita
Summary: This study characterized the transcription profile of microglia in a fear memory conditional mouse model, and found that synapse-related genes were induced while immune-related genes were reduced after fear memory consolidation. The expression of synapse-related genes reversed after fear memory extinction, but immune-related genes remained unchanged. The expression of neurotransmitter release regulators in hippocampal microglia was also found to be correlated with fear memory formation and extinction.
BRAIN RESEARCH BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Skyler Younger, Sydney Boutros, Francesca Cargnin, Shin Jeon, Jae W. Lee, Soo-Kyung Lee, Jacob Raber
Summary: FOXG1 syndrome is a rare and devastating neurodevelopmental disorder characterized by various symptoms. Mouse models with Foxg1 gene mutation displayed phenotypes similar to symptoms of human FS individuals, including anxiety, cognitive impairments, and fear memory deficits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Sarayut Phasuk, Tanita Pairojana, Pavithra Suresh, Chee-Hing Yang, Sittiruk Roytrakul, Shun-Ping Huang, Chien-Chang Chen, Narawut Pakaprot, Supin Chompoopong, Sutisa Nudmamud-Thanoi, Ingrid Y. Liu
Summary: Fear dysregulation is a symptom in PTSD patients, linked to functional abnormalities in the hippocampus. PRDX6, an antioxidant enzyme expressed in the brain, has been found to play a role in fear regulation. Knockout mice lacking Prdx6 displayed enhanced fear response, which was reduced by injecting Prdx6 lentivirus into the brain. Proteomic analysis revealed upregulated proteins in the MAPK pathway in the hippocampus of Prdx6(-/-) mice during fear memory retrieval.
Article
Multidisciplinary Sciences
Lien D. Nguyen, Luca G. Nolte, Winston J. T. Tan, Denise Giuvelis, Joseph Santos-Sacchi, Edward Bilsky, Barbara E. Ehrlich
Summary: NCS1 plays a modulatory role in sensory perceptions and cognition, particularly in male mice, with little impact on affective and cognitive behaviors. Loss of NCS1 in the peripheral nervous system may be of clinical interest, especially in terms of potential pharmacological targeting. Further studies on conditional KO models will help elucidate the physiological significance of NCS1.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Jeremy M. Trott, Ann N. Hoffman, Irina Zhuravka, Michael S. Fanselow
Summary: Fear conditioning is a commonly used laboratory procedure to model learning, memory, and anxiety disorders. Recent findings show that under certain conditions, running, jumping, or darting can replace freezing as the dominant conditioned response. These findings raise important methodological and theoretical questions regarding the measurement and expression of fear in rodents. The study also reveals that different behaviors may be indicative of transitions between different defensive responses and emotional states.
Article
Biochemistry & Molecular Biology
Johannes Kornhuber, Iulia Zoicas
Summary: NPY reduces social fear expression by acting on DLS and CeA, not effective in DH, MeA, and BLA regions. It also exhibits anxiolytic effects when administered in DH, DLS, CeA, and BLA, but not in MeA. This suggests that different neural circuitries are involved in the effects of NPY on social fear expression and anxiety-like behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Bastian Brauer, Nicolas Merino-Veliz, Constanza Ahumada-Marchant, Gloria Arriagada, Fernando J. Bustos
Summary: Using CRISPR/Cas9 gene editing, researchers found that knocking out KMT2C expression in cortical neurons and the mouse brain led to decreased KMT2C levels and the development of repetitive behaviors, social deficits, and intellectual disability resembling ASD. This study sheds light on the importance of KMT2C in neurodevelopmental processes and establishes a valuable model for understanding the cellular and molecular mechanisms underlying KMT2C mutations and their relationship to Kleefstra syndrome 2 and ASD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Psychology, Biological
Ben Turley, Adam P. Swiercz, Laxmi Iyer, Paul J. Marvar
Summary: A customizable software program was developed for Ponemah to assess the internal physiological state of animals in real-time, providing valuable insights into mechanisms of neuropsychiatric diseases.
PHYSIOLOGY & BEHAVIOR
(2021)
Meeting Abstract
Immunology
H. F. Green, L. Brodin, P. Greengard, L. Berg, P. Svenningsson
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Correction
Cell Biology
Zhiying Li, Leah Kelly, Myriam Heiman, Paul Greengard, Jeffrey Michael Friedman
Article
Biochemistry & Molecular Biology
Akinori Nishi, Miriam Matamales, Veronica Musante, Emmanuel Valjent, Mahomi Kuroiwa, Yosuke Kitahara, Heike Rebholz, Paul Greengard, Jean-Antoine Girault, Angus C. Nairn
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Neurosciences
Ana Milosevic, Thomas Liebmann, Margarete Knudsen, Nicoletta Schintu, Per Svenningsson, Paul Greengard
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Biochemistry & Molecular Biology
J-S Seo, J. Wei, L. Qin, Y. Kim, Z. Yan, P. Greengard
MOLECULAR PSYCHIATRY
(2017)
Correction
Neurosciences
Weixing Shen, Joshua L. Plotkin, Veronica Francardo, Wai Kin D. Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jurgen Wess, Richard R. Neubig, Craig W. Lindsley, P. Jeffrey Conn, Paul Greengard, Erwan Bezard, M. Angela Cenci, D. James Surmeier
Article
Biochemistry & Molecular Biology
J-S Seo, P. Zhong, A. Liu, Z. Yan, P. Greengard
MOLECULAR PSYCHIATRY
(2018)
Article
Multidisciplinary Sciences
Ilaria Ceglia, Ko-Woon Lee, Michael E. Cahill, Steven M. Graves, David Dietz, Dalton J. Surmeier, Eric J. Nestler, Angus C. Nairn, Paul Greengard, Yong Kim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, Per Svenningsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, Victor Bustos
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Victor Bustos, Maria V. Pulina, Ashley Bispo, Alison Lam, Marc Flajolet, Fred S. Gorelick, Paul Greengard
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Victor Bustos, Maria V. Pulina, Yildiz Kelahmetoglu, Subhash C. Sinha, Fred S. Gorelick, Marc Flajolet, Paul Greengard
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Mingming Zhou, Jodi Gresack, Jia Cheng, Kunihiro Uryu, Lars Brichta, Paul Greengard, Marc Flajolet
MOLECULAR PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Eitan Wong, George P. Liao, Jerry C. Chang, Peng Xu, Yue-Ming Li, Paul Greengard
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Remzi Karayol, Lucian Medrihan, Jennifer L. Warner-Schmidt, Ben W. Fait, Meghana N. Rao, Eva B. Holzner, Paul Greengard, Nathaniel Heintz, Eric F. Schmidt
Summary: The study demonstrates that the loss of functional 5-HT4R specifically from excitatory neurons of the hippocampus leads to AD-like behavioral responses and an increase in anxiety levels, accompanied by an increase in the number of neurons in different regions of the hippocampus. This research highlights the importance of cell type-based approaches in elucidating the complex actions of neuromodulatory systems on neural circuits.
MOLECULAR PSYCHIATRY
(2021)