期刊
GENES BRAIN AND BEHAVIOR
卷 8, 期 5, 页码 493-499出版社
WILEY
DOI: 10.1111/j.1601-183X.2009.00485.x
关键词
Alcohol; amygdala; limited access paradigm; RNA interference; protein kinase C epsilon; mice
资金
- Public Health Services [AA013588]
- US Army [DAMD17-03-1-0058]
- E.U. Marie Curie Fellowship [MOIF-CT-2004-002812]
Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKC epsilon) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKC epsilon signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKC epsilon in the amygdala reduced ethanol consumption and preference in a limited-access paradigm. Further, mice that are heterozygous for the PKC epsilon allele consume less ethanol compared with wild-type mice in this paradigm. These mice have a > 50% reduction in the abundance of PKC epsilon in the amygdala compared with wild-type mice. We conclude that amygdala PKC epsilon is important for ethanol consumption in mice.
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