Article
Physiology
Megan M. Marron, Matthew Allison, Alka M. Kanaya, Britta Larsen, Alexis C. Wood, David Herrington, Philip Greenland, Iva Miljkovic
Summary: As individuals age, the quantity and quality of skeletal muscle decrease, partly due to the infiltration of fat within muscle tissue. A detailed metabolic analysis of lipoprotein subfractions can provide insights into the correlation between metabolism and skeletal muscle and intermuscular adipose tissue.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Kamil A. Kobak, Pawel Franczuk, Justyna Schubert, Magdalena Dziegala, Monika Kasztura, Michal Tkaczyszyn, Marcin Drozd, Aneta Kosiorek, Liliana Kiczak, Jacek Bania, Piotr Ponikowski, Ewa A. Jankowska
Summary: Cardiac fibroblasts and cardiomyocytes are sensitive to changes in iron homeostasis, which may affect the pathophysiology of myocarditis. Increased expression of transferrin receptor 1 (TFR1) and ferritin in cells treated with MCD serum suggests elevated iron demand.
Article
Nutrition & Dietetics
Aneta Jonczy, Rafal Mazgaj, Rafal Radoslaw Starzynski, Piotr Poznanski, Mateusz Szudzik, Ewa Smuda, Marian Kamyczek, Pawel Lipinski
Summary: This study investigates the interaction between copper and iron metabolism, revealing that regulation of iron absorption in the duodenal enterocytes is based on the interaction between proteins of copper and iron metabolisms rather than systemic regulation in the context of neonatal iron deficiency anemia.
Article
Biochemistry & Molecular Biology
Monika Cendrowska-Pinkosz, Marta Ostrowska-Lesko, Katarzyna Ognik, Magdalena Krauze, Jerzy Juskiewicz, Anna Dabrowska, Jaroslaw Szponar, Slawomir Mandziuk
Summary: Copper is necessary for brain cells and is involved in energy metabolism pathways. Deficiency in copper homeostasis may contribute to neurodegeneration. The regulation of copper in brain tissue remains unclear. This study examines the effects of replacing inorganic copper with copper nanoparticles or completely removing copper from the diet on gene expression related to energy metabolism in the rat prefrontal cortex. The results suggest that these changes in gene expression may be due to an increased demand for NADH in the rat brain's prefrontal cortex, possibly as an adaptation effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
C. Cabrera, C. Frisk, U. Lofstrom, P. Lynga, C. Linde, C. Hage, H. Persson, M. J. Eriksson, H. Wallen, B. Persson, M. Ekstrom
Summary: This study investigates the relationship between iron deficiency and the expression of genes involved in iron metabolism in human myocardium and skeletal muscle. The results show that the expression of TfR1 is increased in patients with iron deficiency, indicating a physiologically upregulated expression of TfR1 to meet intracellular iron needs.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Tricia L. Hart, Kristina S. Petersen, Penny M. Kris-Etherton
Summary: This study conducted a systematic review of the effects of cottonseed oil on lipid metabolism and found that cottonseed oil can improve lipid/lipoprotein levels compared with olive oil. The predictive equations suggest that cottonseed oil can be incorporated into a healthy dietary pattern without significantly affecting lipids/lipoproteins.
Review
Biochemistry & Molecular Biology
Geir Bjorklund, Massimiliano Peana, Lyudmila Pivina, Alexandru Dosa, Jan Aaseth, Yuliya Semenova, Salvatore Chirumbolo, Serenella Medici, Maryam Dadar, Daniel-Ovidiu Costea
Summary: Iron deficiency is common in obese patients due to increased hepcidin levels and inflammation. Bariatric surgery can improve iron absorption by reducing inflammation and hepcidin levels. Monitoring iron status and recommending iron supplementation is important for post-bariatric surgery patients.
Article
Multidisciplinary Sciences
Hyungjong Park, Yoonkyung Chang, Heajung Lee, Iksun Hong, Tae-Jin Song
Summary: The study investigates the association between total cholesterol (TC) variability and the occurrence of venous thromboembolism (VTE) using a Korean database. The results show a positive correlation between higher TC variability and the occurrence of VTE, emphasizing the importance of maintaining stable TC levels to prevent VTE.
Review
Nutrition & Dietetics
Marcin Delijewski, Aleksandra Barton, Beata Maksym, Natalia Pawlas
Summary: Iron is a crucial transition metal in physiological processes, but it can also be toxic due to its involvement in free radical formation. Impaired iron metabolism leads to iron deficiency, anemia, and iron overload, with different prevalences in transplant patients. Limited knowledge exists on iron metabolism in lung graft recipients and donors, complicated further by the potential impact of drugs. This overview highlights the importance of understanding iron turnover in transplant patients and assessing drug effects on iron metabolism for perioperative treatment in transplantology.
Article
Plant Sciences
Maria Bernal, Ute Kraemer
Summary: The text discusses the interaction between iron and copper in biological systems and their importance in biological processes. Studies have found an inter-dependence of iron and copper in certain eukaryotes, including green algae, yeast, and mammals. In Arabidopsis, copper deficiency can lead to secondary iron deficiency, affecting root-to-shoot iron translocation and ferroxidase activity.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Medicine, General & Internal
Ridha I. S. Alnuwaysir, Martijn F. Hoes, Dirk J. van Veldhuisen, Peter van der Meer, Niels Grote Beverborg
Summary: Iron deficiency is a common comorbidity in heart failure patients and can have negative effects on exercise capacity, quality of life, hospitalization rates, and mortality risks. Intravenous iron correction has shown promising results in improving symptoms and reducing hospitalizations in heart failure patients. However, the underlying pathophysiology of iron deficiency in heart failure is still poorly understood.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Krzysztof Mlodzinski, Michal Swiatczak, Justyna Rohun, Jacek Wolf, Krzysztof Narkiewicz, Marcin Hellmann, Ludmila Danilowicz-Szymanowicz
Summary: Vascular aging is a physiological process involving various types of vessels. Iron disorders may contribute to vascular aging, but further research is needed to determine the exact relationship.
Article
Multidisciplinary Sciences
D. Gashu, P. C. Nalivata, T. Amede, E. L. Ander, E. H. Bailey, L. Botoman, C. Chagumaira, S. Gameda, S. M. Haefele, K. Hailu, E. J. M. Joy, A. A. Kalimbira, D. B. Kumssa, R. M. Lark, I. S. Ligowe, S. P. McGrath, A. E. Milne, A. W. Mossa, M. Munthali, E. K. Towett, M. G. Walsh, L. Wilson, S. D. Young, M. R. Broadley
Summary: Micronutrient deficiencies are widespread among people in sub-Saharan Africa due to limited access to micronutrient-rich food sources. Research in Ethiopia and Malawi shows geographical variation in the micronutrient composition of staple cereal grains, influenced by soil and environmental factors. Understanding these geographical effects is crucial for designing interventions to alleviate micronutrient deficiencies.
Review
Biochemistry & Molecular Biology
Christina A. Porras, Tracey A. Rouault
Summary: This review provides an overview of the role of iron homeostasis disruption in various neurological disorders, discussing the consequences of both iron accumulation and deficiency. It also examines the history of animal models and presents a comparison of patients with a newly discovered neurodegenerative disorder caused by mutations in iron regulatory protein 2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Thibaud Lefebvre, Muriel Coupaye, Marina Esposito-Farese, Nathalie Gault, Neila Talbi, Caroline Quintin, Caroline Schmitt, Soumeya Bekri, Andre Bado, Herve Puy, Simon Msika, Carole Brasse-Lagnel, Zoubida Karim
Summary: After sleeve gastrectomy, levels of iron-related markers such as sTfR and PPIX decreased while serum hepcidin levels increased. DMT1 abundance was negatively correlated with serum hepcidin levels, and ferroportin abundance remained unchanged. These results suggest effective iron recovery pathways post-operatively involving suppression of inflammation and improvement in iron absorption and erythropoiesis.
Article
Biochemistry & Molecular Biology
Beatrice Dufrusine, Verena Damiani, Emily Capone, Damiana Pieragostino, Enrico Dainese, Margot De Marco, Francesca Reppucci, Maria C. Turco, Alessandra Rosati, Liberato Marzullo, Gianluca Sala, Michele Sallese, Vincenzo De Laurenzi
Summary: The study demonstrates that BAG3 activates human fibroblasts to release cytokines supporting the growth and migration of PDAC cells. Blocking the BAG3 axis inhibits cytokine release and migratory phenotype in PDAC cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Infectious Diseases
Ylenia D'Agostino, Teresa Rocco, Carlo Ferravante, Amalia Porta, Alessandra Tosco, Valeria Mirici Cappa, Jessica Lamberti, Elena Alexandrova, Domenico Memoli, Ilaria Terenzi, Concetta Pironti, Oriana Motta, Alessandro Weisz, Giorgio Giurato, Francesca Rizzo
Summary: The SARS-CoV-2 virus is continuously evolving, with the appearance of new variants characterized by multiple genomic mutations. This study proposes a PCR-based assay panel for the identification of SARS-CoV-2 genotypes, which is rapid, sensitive, and low-cost. The assay can detect variations in multiple viral genome positions and is effective even in diluted and poor-quality samples.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Daniela Eletto, Fatima Mentucci, Antonia Voli, Antonello Petrella, Amalia Porta, Alessandra Tosco
Summary: This article discusses how microbial infections are sensed by the host immune system and how H. pylori escapes immune recognition through camouflage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Margot De Marco, Vanessa Gauttier, Sabrina Pengam, Caroline Mary, Bianca Ranieri, Anna Basile, Michela Festa, Antonia Falco, Francesca Reppucci, Anna Lisa Cammarota, Fausto Acernese, Vincenzo De Laurenzi, Gianluca Sala, Sergio Brongo, Masayuki Miyasaka, Shabnam Shalapour, Bernard Vanhove, Nicolas Poirier, Roberta Iaccarino, Michael Karin, Maria Caterina Turco, Alessandra Rosati, Liberato Marzullo
Summary: This study investigates the functional connection between BAG3 and SIRP alpha pathways and finds that combined blockade of these pathways can effectively inhibit pancreatic cancer growth and metastasis, reduce fibrosis and activation marker expression, and enhance anti-tumor immune cell response.
CELL DEATH DISCOVERY
(2022)
Article
Biology
Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto, Maria A. Oliva, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Francesco Chiuso, Salvatore Castaldo, Giovanni Scala, Virginia Campani, Valeria Nele, Giuseppe De Rosa, Chiara D'Ambrosio, Corrado Garbi, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Antonella Arcella, Antonio Feliciello
Summary: The study identifies praja2 as an essential regulator of cancer cell metabolism in glioblastoma (GBM) and a potential therapeutic target to suppress GBM growth. Silencing praja2 using siRNA delivered by nanoparticles reduces tumor size in GBM-bearing mice.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pathology
Annamaria Salvati, Ileana Carnevali, Elena Alexandrova, Sofia Facchi, Susanna Ronchi, Laura Libera, Nora Sahnane, Domenico Memoli, Jessica Lamberti, Sonia Amabile, Stefano Pepe, Roberta Tarallo, Fausto Sessa, Alessandro Weisz, Maria Grazia Tibiletti, Francesca Rizzo
Summary: This study evaluated the mutational profile of ovarian cancer patients in Italy using next-generation sequencing, identifying TP53 as the gene with highest mutational rate and detecting a subset of patients with pathogenic variants sensitive to PARP-inhibitor therapies. Germline analysis revealed carrier of pathogenic germline variants in actionable genes.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michele Salemi, Giovanna Marchese, Giuseppe Lanza, Filomena I. I. Cosentino, Maria Grazia Salluzzo, Francesca A. Schillaci, Giovanna Maria Ventola, Angela Cordella, Maria Ravo, Raffaele Ferri
Summary: Parkinson's disease (PD) is a neurodegenerative synucleinopathy with an unclear molecular pathomechanism. This study analyzed miRNAs on peripheral blood mononuclear cells from 30 participants to identify differentially expressed miRNAs in PD compared to healthy controls. The study also explored the pathways influenced by these miRNAs and their potential association with PD susceptibility. Several dysregulated miRNAs and their putative targets were identified, suggesting their potential as diagnostic markers and outcome measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fabiola Marino, Nadia Salerno, Mariangela Scalise, Luca Salerno, Annalaura Torella, Claudia Molinaro, Antonio Chiefalo, Andrea Filardo, Chiara Siracusa, Giuseppe Panuccio, Carlo Ferravante, Giorgio Giurato, Francesca Rizzo, Michele Torella, Maria Donniacuo, Antonella De Angelis, Giuseppe Viglietto, Konrad Urbanek, Alessandro Weisz, Daniele Torella, Eleonora Cianflone
Summary: Diabetic cardiomyopathy (DCM) is a major cause of cardiovascular complications in diabetes mellitus (DM). Two different types of diabetes, type 1 and type 2, exhibit different effects on cardiac structure, function and gene expression. Animal models induced by different glucose regulators have been used to compare and study these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Anna Basile, Carla Zannella, Margot De Marco, Giuseppina Sanna, Gianluigi Franci, Massimiliano Galdiero, Aldo Manzin, Vincenzo De Laurenzi, Massimiliano Chetta, Alessandra Rosati, Maria Caterina Turco, Liberato Marzullo
Summary: Researchers have developed a specific antibody against IFITM2 that can interfere with the invasion of SARS-CoV-2 and reduce its damage to host cells. This antibody also reduces the damage caused by other viruses such as HSV and RSV, suggesting that IFITM2 may have a similar mechanism of invasion to other viruses. These results demonstrate the specific role of IFITM2 in viral entry and its potential as a cell target for antiviral therapies.
ANTIVIRAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Annamaria Salvati, Carlo Ferravante, Jessica Lamberti, Teresa Rocco, Elena Alexandrova, Ylenia D'Agostino, Maksim Sorokin, Victor Efimov, Anton Buzdin, Oriana Strianese, Giovanni Nassa, Roberta Tarallo, Alessandro Weisz, Francesca Rizzo, Giorgio Giurato
Summary: The ongoing COVID-19 pandemic has had significant implications for public health and alters the host transcriptome. To understand the virus's effect on host cell transcriptome, a dataset was generated from nasopharyngeal swabs of 35 individuals infected with SARS-CoV-2 from the Campania region in Italy. This dataset can help elucidate gene interactions and contribute to the development of therapeutic pathways.
Article
Microbiology
Christopher Riccardi, Marzia Calvanese, Veronica Ghini, Tania Alonso-Vasquez, Elena Perrin, Paola Turano, Giorgio Giurato, Alessandro Weisz, Ermenegilda Parrilli, Maria Luisa Tutino, Marco Fondi
Summary: This study investigates the maintenance of metabolic homeostasis in a cold-adapted marine bacterium during growth at significantly different temperatures. The research shows a strong metabolic stability at the level of the main central metabolites but significant changes in gene expression at the transcriptional level. These findings suggest a transcriptomic buffering of cellular metabolism to produce overlapping metabolic phenotypes despite the temperature gap.
Article
Biochemistry & Molecular Biology
Massimiliano Chetta, Anna Lisa Cammarota, Margot De Marco, Nenad Bukvic, Liberato Marzullo, Alessandra Rosati
Summary: Climate change and globalization have increased the risk of vector-borne diseases in Europe. In Italy, tropical vectors have been found to carry viruses causing viral encephalitis. The World Health Organization has recommended measures to prevent the spreading of infectious agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Marzia Di Donato, Erika Di Zazzo, Annamaria Salvati, Carmela Sorrentino, Giorgio Giurato, Donatella Fiore, Maria Chiara Proto, Monica Rienzo, Amelia Casamassimi, Patrizia Gazzerro, Maurizio Bifulco, Gabriella Castoria, Alessandro Weisz, Giovanni Nassa, Ciro Abbondanza
Summary: This study provides insights into the potential tumor-promoting functions of RIZ2 in CRC, demonstrating its involvement in EGF pathway deregulation and its impact on CRC cell behavior.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Elisabetta Fratta, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Jessica Dal Col, Alessandro Weisz, Agostino Steffan, Barbara Montico
Summary: Autophagy plays a crucial role in cutaneous melanoma, but its impact on tumor development remains controversial. Of particular interest, autophagy is increased in BRAF-mutant melanoma and impairs targeted therapy. Moreover, recent studies have highlighted the involvement of mitophagy and secretory autophagy in BRAF-mutant melanoma.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Giorgio Giurato, Ilaria Terenzi, Francesco Chiuso, Annamaria Salvati, Francesca Rizzo, Roberta Tarallo, Alessandro Weisz, Giovanni Nassa
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)