Article
Medicine, Research & Experimental
Huai-Chia Chuang, Ming-Han Chen, Yi-Ming Chen, Huang-Yu Yang, Yi-Ru Ciou, Chia-Hsin Hsueh, Ching-Yi Tsai, Tse-Hua Tan
Summary: This study found that a protein called bactericidal/permeability-increasing protein (BPI) is overexpressed in T cells and T cell-derived exosomes of SLE patients. BPI may serve as a biomarker and pathogenic factor for SLE nephritis, hepatitis, and arthritis, as it is associated with multi-tissue inflammation and modulation of Treg cell differentiation.
Review
Immunology
Meghana Eswarappa, Chiara Cantarelli, Paolo Cravedi
Summary: Systemic lupus erythematosus is a multiorgan autoimmune disease with complex pathogenesis and limited treatment options. Recent studies have shown that erythropoietin (EPO) has immunomodulatory effects that may help reduce disease severity in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Rui Zhang, Jinlin Miao, Kui Zhang, Bei Zhang, Xing Luo, Haoyang Sun, Zhaohui Zheng, Ping Zhu
Summary: This study investigated the changes in quantity and function of Treg cell subsets in RA patients, finding that Th1-like Treg cells are the predominant subset in the synovial fluid of RA patients but with defective suppressive function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rajkumar Venkatadri, Vikram Sabapathy, Murat Dogan, Rahul Sharma
Summary: Lupus glomerulonephritis is a complex autoimmune disease with limited treatment options. Treg-enhancement and indirect Treg-modulation strategies are being investigated.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Amelie M. Jule, Ki Pui Lam, Maria Taylor, Kacie J. Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, Siobhan M. Case, Mia Chandler, Margaret H. Chang, Ezra M. Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan Hausmann, Melissa M. Hazen, Erin Janssen, Jeffrey Lo, Mindy S. Lo, Esra Meidan, Jordan E. Roberts, Holly Wobma, Mary Beth F. Son, Robert P. Sundel, Pui Y. Lee, Peter T. Sage, Talal A. Chatila, Peter A. Nigrovic, Deepak A. Rao, Lauren A. Henderson
Summary: Tph cells play a crucial role in driving B cell maturation and antibody production in seropositive rheumatoid arthritis. In this study, the researchers investigated T cell-B cell interactions in juvenile oligoarthritis and found dysregulated Tph cells promoting B cell antibody production in the synovial fluid of patients with antinuclear antibodies. The single-cell transcriptomics analysis revealed the upregulation of B cell help-associated genes in Tph cells from ANA-positive patients. These findings highlight the central role of disordered T cell-help to B cells in autoantibody-positive arthritides.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Julia N. Khantakova, Sergey V. Sennikov
Summary: The collaboration of various disciplines seeks to find new methods to cure impaired body functions through repairing, replacing, or regenerating cells, tissues, or organs. The possibility of reprogramming stable differentiated cells opens doors to new therapeutic strategies against diseases caused by the loss or dysfunction of specific cells. Understanding the factors that contribute to T cell plasticity is not only clinically important but also improves the knowledge of cell differentiation and developmental biology.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Review
Immunology
Xingyun Zhao, Shifen Wang, Shengjun Wang, Jue Xie, Dawei Cui
Summary: This review systematically summarizes the role of the mTOR signaling pathway in the pathogenesis of systemic lupus erythematosus (SLE), regulatory T cell dysfunction, and the treatment of SLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chun-Ling Liang, Weihui Lu, Feifei Qiu, Dan Li, Huazhen Liu, Fang Zheng, Qunfang Zhang, Yuchao Chen, Chuanjian Lu, Bin Li, Zhenhua Dai
Summary: PF can ameliorate lupus nephritis by reducing proteinuria, serum creatinine, anti-dsDNA levels, and renal cellular infiltration, as well as by improving renal immunopathology. It also has the potential to promote Treg differentiation and proliferation mediated by M2 macrophages, suggesting it may be used as a possible treatment for lupus nephritis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biology
Daniil Shevyrev, Valeriy Tereshchenko, Elena Blinova, Nadezda Knauer, Ekaterina Pashkina, Alexey Sizikov, Vladimir Kozlov
Summary: The study revealed that the proliferation of Treg cells in patients with rheumatoid arthritis under HP cytokine stimulation is lower compared to healthy individuals, and the suppressive activity decreases, which may lead to the proliferation of self-reactive T cell clones.
Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Saige L. Pompura, David A. Hafler, Margarita Dominguez-Villar
Summary: Cellular metabolic remodeling is closely linked to the development, activation, differentiation, function, and survival of T cells, and specific lipid species can alter the function and metabolism of T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: This study found that kidney allograft rejection is associated with an imbalance between immune cells with effector/memory functions and those with regulatory properties, manifested as a decrease in the percentage of circulating B cells and an increase in the ratio of CD28-CD8+ T cells to Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kun-Po Li, Anke Faehnrich, Eron Roy, Carla M. Cuda, H. Leighton Grimes, Harris R. Perlman, Kathrin Kalies, David A. Hildeman
JOURNAL OF IMMUNOLOGY
(2017)
Article
Medicine, Research & Experimental
Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda, Harris Perlman
JOURNAL OF TRANSLATIONAL MEDICINE
(2016)
Review
Rheumatology
Carla M. Cuda, Richard M. Pope, Harris Perlman
NATURE REVIEWS RHEUMATOLOGY
(2016)
Article
Immunology
Alexander V. Misharin, Luisa Morales-Nebreda, Paul A. Reyfman, Carla M. Cuda, James M. Walter, Alexandra C. McQuattie-Pimentel, Ching-I Chen, Kishore R. Anekalla, Nikita Joshi, Kinola J. N. Williams, Hiam Abdala-Valencia, Tyrone J. Yacoub, Monica Chi, Stephen Chiu, Francisco J. Gonzalez-Gonzalez, Khalilah Gates, Anna P. Lam, Trevor T. Nicholson, Philip J. Homan, Saul Soberanes, Salina Dominguez, Vince K. Morgan, Rana Saber, Alexander Shaffer, Monique Hinchcliff, Stacy A. Marshall, Ankit Bharat, Sergejs Berdnikovs, Sangeeta M. Bhorade, Elizabeth T. Bartom, Richard I. Morimoto, William E. Balch, Jacob I. Sznajder, Navdeep S. Chandel, Gokhan M. Mutlu, Manu Jain, Cara J. Gottardi, Benjamin D. Singer, Karen M. Ridge, Neda Bagheri, Ali Shilatifard, G. R. Scott Budinger, Harris Perlman
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Immunology
FuNien Tsai, Philip J. Homan, Hemant Agrawal, Alexander V. Misharin, Hiam Abdala-Valencia, G. Kenneth Haines, Salina Dominguez, Christina L. Bloomfield, Rana Saber, Anthony Chang, Chandra Mohan, Jack Hutcheson, Anne Davidson, G. R. Scott Budinger, Philippe Bouillet, Andrea Dorfleutner, Christian Stehlik, Deborah R. Winter, Carla M. Cuda, Harris Perlman
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Immunology
Hadijat M. Makinde, Carla M. Cuda, Talia B. Just, Harris R. Perlman, Steven J. Schwulst
JOURNAL OF IMMUNOLOGY
(2017)
Review
Critical Care Medicine
Hadijat M. Makinde, Talia B. Just, Carla M. Cuda, Harris Perlman, Steven J. Schwulst
Article
Rheumatology
Arthur M. Mandelin, Philip J. Homan, Alexander M. Shaffer, Carla M. Cuda, Salina T. Dominguez, Emily Bacalao, Mary Carns, Monique Hinchcliff, Jungwha Lee, Kathleen Aren, Anjali Thakrar, Anna B. Montgomery, S. Louis Bridges, Joan M. Bathon, John P. Atkinson, David A. Fox, Eric L. Matteson, Christopher D. Buckley, Costantino Pitzalis, Deborah Parks, Laura B. Hughes, Laura Geraldino-Pardilla, Robert Ike, Kristine Phillips, Kerry Wright, Andrew Filer, Stephen Kelly, Eric M. Ruderman, Vince Morgan, Hiam Abdala-Valencia, Alexander V. Misharin, G. Scott Budinger, Elizabeth T. Bartom, Richard M. Pope, Harris Perlman, Deborah R. Winter
ARTHRITIS & RHEUMATOLOGY
(2018)
Article
Immunology
Elise V. Mike, Hadijat M. Makinde, Maria Gulinello, Kamala Vanarsa, Leal Herlitz, Gaurav Gadhvi, Deborah R. Winter, Chandra Mohan, John G. Hanly, C. C. Mok, Carla M. Cuda, Chaim Putterman
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Immunology
Elise V. Mike, Hadijat M. Makinde, Evan Der, Ariel Stock, Maria Gulinello, Gaurav T. Gadhvi, Deborah R. Winter, Carla M. Cuda, Chaim Putterman
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Hadijat M. Makinde, Talia B. Just, Carla M. Cuda, Nicola Bertolino, Daniele Procissi, Steven J. Schwulst
Article
Immunology
FuNien Tsai, Harris Perlman, Carla M. Cuda
CLINICAL IMMUNOLOGY
(2017)
Article
Rheumatology
Salina Dominguez, Anna B. Montgomery, G. Kenneth Haines, Christina L. Bloomfield, Carla M. Cuda
ARTHRITIS RESEARCH & THERAPY
(2017)
Article
Rheumatology
Susan MacLauchlan, Maria A. Zuriaga, Jose J. Fuster, Carla M. Cuda, Jennifer Jonason, Fernanda Behzadi, Jennifer Parker Duffen, G. Kenneth Haines, Tamar Aprahamian, Harris Perlman, Kenneth Walsh
ARTHRITIS RESEARCH & THERAPY
(2017)
Article
Rheumatology
Samantha A. Chalmers, Jing Wen, Jessica Doerner, Ariel Stock, Carla M. Cuda, Hadijat M. Makinde, Harris Perlman, Todd Bosanac, Deborah Webb, Gerald Nabozny, Jay S. Fine, Elliott Klein, Meera Ramanujam, Chaim Putterman
ARTHRITIS RESEARCH & THERAPY
(2018)