Article
Environmental Sciences
Michelle E. Kossack, Katherine E. Manz, Nathan R. Martin, Kurt D. Pennell, Jessica Plavicki
Summary: Dioxin and dioxin-like compounds are environmental contaminants that induce toxicity by binding to the aryl hydrocarbon receptor (AHR). The zebrafish model has been used to study developmental toxicity caused by exposure to AHR ligands such as dioxin. In this study, targeted gas chromatography (GC) and non-targeted liquid chromatography (LC) were used to quantify TCDD uptake, model its elimination dynamics, and determine its impact on the zebrafish metabolome. The results showed that environmentally relevant body burdens of TCDD were produced in zebrafish through different waterborne exposures, and TCDD exposure affected metabolic pathways associated with AHR signaling and brain development.
Article
Nutrition & Dietetics
Wurood Hantoosh Neamah, Alex Rutkovsky, Osama Abdullah, Kiesha Wilson, Ryan Bloomquist, Prakash Nagarkatti, Mitzi Nagarkatti
Summary: This study demonstrates that Resveratrol (RSV), an AhR antagonist, reduces the induction and function of murine myeloid-derived suppressor cells (MDSCs) induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). RSV reverses the effects of TCDD on macrophages and dendritic cells, as well as the upregulation of critical molecules involved in TCDD-mediated induction and immunosuppressive functions of MDSCs. RSV treatment decreases the energetic demands induced by TCDD. These findings suggest the potential use of RSV to attenuate the immunosuppressive properties of MDSCs.
Article
Environmental Sciences
Jyoti Bhuju, Kristin M. Olesen, Clarisse S. Muenyi, Tejesh S. Patel, Robert W. Read, Lauren Thompson, Omar Skalli, Qi Zheng, Elizabeth A. Grice, Carrie Hayes Sutter, Thomas R. Sutter
Summary: Exposure to TCDD during pregnancy and lactation in mice resulted in skin effects such as acanthosis and chloracne-like sebaceous gland hypoplasia, which were reversible and did not cause long-term immunosuppression. Additionally, increased expression of CYP1A1 and CYP1B1 in the skin of exposed mice was observed, with co-localization with progenitor cells and stem cell niches.
Article
Environmental Sciences
Min-Kyung Cho, Jae-Gon Park, Hisato Iwata, Eun-Young Kim
Summary: Studies have revealed that exposure to TCDD resulted in severe weight loss and thymus atrophy in chicken embryos, indicating that TCDD affects the immune system of chicken embryos by suppressing T cell-mediated immune responses. Thymic transcriptome analysis suggested that TCDD-induced thymus atrophy may be associated with alterations in multiple signaling pathways, leading to significant changes in the expression levels of immune-related genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Marine & Freshwater Biology
Monica S. Yue, Shannon E. Martin, Nathan R. Martin, Michael R. Taylor, Jessica S. Plavicki
Summary: Exposure to TCDD in zebrafish disrupts the development of the subintestinal venous plexus (SIVP) which vascularizes the liver, kidney, gut, and pancreas, as well as the superficial annular vessel (SAV) crucial for retinal vasculature. TCDD exposure also increases the expression of bmp4, a key molecular mediator of SIVP morphogenesis.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Jae Gon Park, Hisato Iwata, Nguyen Minh Tue, Tatsuya Kunisue, Eun-Young Kim
Summary: Researchers have discovered a naturally occurring dioxin called 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD) in the marine environment, synthesized by red algae. They investigated the effects of this compound on bird embryos and found that 1,3,7-TriBDD exposure may lead to health issues such as diabetes and cancer. Compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,3,7-TriBDD had different impacts on the phenotype and transcriptome of chicken embryos, potentially resulting in different severity of effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Reproductive Biology
Javier Esteban, Ismael Sanchez-Perez, Gerd Hamscher, Hanna M. Miettinen, Merja Korkalainen, Matti Viluksela, Raimo Pohjanvirta, Helen Hakansson
Summary: The study indicates that AHR and TCDD have significant effects on the retinoid system, with differences in impact based on sex among wild-type mice, and variations in concentrations of different retinoid forms in the liver, kidneys, and blood.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Environmental Sciences
Qi Yuan, J. Brett Sallach, Geoff Rhodes, Anthony Bach, Robert Crawford, Hui Li, Cliff T. Johnston, Brian J. Teppen, Norbert E. Kaminski, Stephen A. Boyd
Summary: TCDD is a toxic and persistent organic pollutant. Previous studies showed that TCDD adsorbed to inorganic geosorbents had similar bioavailability to mice as TCDD dissolved in corn oil, while sequestration by activated carbons eliminated bioavailability.
Review
Food Science & Technology
Jiuhe Gao, Yuqing Xu, Tian Zhong, Xi Yu, Ling Wang, Ying Xiao, Ye Peng, Quancai Sun
Summary: Dioxins, highly toxic trace environmental contaminants, are regarded as typical contaminants in food. This review discusses the mechanisms and toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the human metabolism system and its plausible correlation with five metabolic disorders.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Muhammed Fatih Dogan, Nese Basak Turkmen, Asli Taslidere, Yasemin Sahin, Osman Ciftci
Summary: The study investigated the protective role of capsaicin in TCDD-induced toxicity in rats, finding that capsaicin treatment reduced TBARS levels, increased GSH level and SOD activity, and attenuated TCDD-induced histopathological alterations in the heart, liver, and kidney tissues. Capsaicin may act as a preventive agent in TCDD toxicity by regulating oxidative imbalance and histopathological alterations in rat tissues.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Microbiology
Thi Lan Anh Nguyen, Ha Thi Cam Dang, Ton That Huu Dat, Bernd W. Brandt, Wilfred F. M. Roling, Abraham Brouwer, Rob J. M. van Spanning
Summary: The succession of bacterial communities during the biodegradation of 2,3,7,8-TCDD was studied, and it was found that an increase in the relative abundance of certain bacterial genera correlated with increased degradation of 2,3,7,8-TCDD. The addition of different carbon and energy sources had varying effects on the degradation rate of 2,3,7,8-TCDD.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Russell R. Fling, Timothy R. Zacharewski
Summary: TCDD-induced changes in gut microbiota composition increase levels of lactobacilli species and are associated with secondary bile acid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Michela Novelli, Pascale Beffy, Matilde Masini, Chiara Vantaggiato, Luisa Martino, Lorella Marselli, Piero Marchetti, Vincenzo De Tata
Summary: Exposure to environmental pollutant TCDD affects pancreatic islets, especially beta cells, leading to cell death, ultrastructural alterations, decreased insulin secretion, and changes in gene expression. TCDD exposure significantly reduces cell survival and insulin secretion, causes ultrastructural changes in beta cells, and alters gene expression profiles in isolated islets.
Article
Engineering, Environmental
Bao-Anh Thi Nguyen, Ju-Liang Hsieh, Shou-Chen Lo, Sui-Yuan Wang, Chun-Hsiung Hung, Eugene Huang, Shih-Hsun Hung, Wei-Chih Chin, Chieh-Chen Huang
Summary: In this study, the endophytic bacterium Burkholderia cenocapacia 869T2 was found to degrade the most toxic dioxin congener TCDD by nearly 95% after one-week of an aerobic incubation, with a potential general dioxin degradation pathway proposed. The investigation also revealed the crucial role of a catabolic gene, L-2-haloacid dehalogenase (2-HAD), in dioxin dehalogenation in aerobic conditions. Transcriptional analysis indicated high gene expressions of catabolic genes involved in dioxin metabolism in the presence of TCDD.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Laura Gaspari, Francoise Paris, Nicolas Kalfa, Marie-Odile Soyer-Gobillard, Charles Sultan, Samir Hamamah
Summary: Previous studies indicate the potential for transgenerational inheritance of disease susceptibility due to endocrine disruptors. While there is substantial evidence on the multigenerational and transgenerational effects of TCDD, studies on its impact on human reproductive health are limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shogo Tsuji, Kosei Tanaka, Shinji Takenaka, Ken-ichi Yoshida
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2015)
Article
Biotechnology & Applied Microbiology
Hirokazu Suzuki, Jun Ishii, Akihiko Kondo, Ken-ichi Yoshida
BIOTECHNOLOGY LETTERS
(2015)
Article
Microbiology
Kosei Tanaka, Kana Iwasaki, Takuya Morimoto, Takatsugu Matsuse, Tomohisa Hasunuma, Shinji Takenaka, Onuma Chumsakul, Shu Ishikawa, Naotake Ogasawara, Ken-ichi Yoshida
Article
Food Science & Technology
Itsuko Fukuda, Shin Nishiumi, Rie Mukai, Ken-ichi Yoshida, Hitoshi Ashida
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2015)
Article
Microbiology
Shinji Takenaka, Ayaka Miyatake, Kosei Tanaka, Ampin Kuntiya, Charin Techapun, Noppol Leksawasdi, Phisit Seesuriyachan, Thanongsak Chaiyaso, Masanori Watanabe, Ken-ichi Yoshida
JOURNAL OF BASIC MICROBIOLOGY
(2015)
Article
Microbiology
Ayako Terakawa, Ayane Natsume, Atsushi Okada, Shogo Nishihata, Junko Kuse, Kosei Tanaka, Shinji Takenaka, Shu Ishikawa, Ken-ichi Yoshida
Article
Agriculture, Multidisciplinary
Shinji Takenaka, Mayo Umeda, Hisanori Senba, Dai Koyama, Kosei Tanaka, Ken-ichi Yoshida, Mikiharu Doi
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2017)
Article
Biotechnology & Applied Microbiology
Shinji Takenaka, Kenji Yoshida, Kosei Tanaka, Ken-ichi Yoshida
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Shigeki Kada, Atsushi Ishikawa, Yoshifumi Ohshima, Ken-ichi Yoshida
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2013)
Article
Biotechnology & Applied Microbiology
Shinji Takenaka, Yuuta Honma, Kenji Yoshida, Ken-ichi Yoshida
BIOTECHNOLOGY LETTERS
(2013)
Article
Microbiology
Shuhei Ueda, Ryohei Nomoto, Ken-ichi Yoshida, Ro Osawa
Article
Biotechnology & Applied Microbiology
Thi Lan Thanh Bien, Shogo Tsuji, Kosei Tanaka, Shinji Takenaka, Ken-ichi Yoshida
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY
(2014)
Article
Multidisciplinary Sciences
Risa Takagi, Kengo Sasaki, Daisuke Sasaki, Itsuko Fukuda, Kosei Tanaka, Ken-ichi Yoshida, Akihiko Kondo, Ro Osawa
Article
Biotechnology & Applied Microbiology
Kosei Tanaka, Shinji Takanaka, Ken-ichi Yoshida
Article
Microbiology
Andres Miguel-Arribas, Ling Juan Wu, Claudia Michaelis, Ken-ichi Yoshida, Elisabeth Grohmann, Wilfried J. J. Meijer
Summary: Genes involved in cellular processes are often clustered in operons controlled by upstream promoters. Spurious transcription can undermine regulation, but can be mitigated by terminators and antitermination systems. Bacterial conjugation involves many genes organized in operons, some of which possess a bipartite antitermination system. Some plasmids in Gram-positive bacteria lack an antitermination system in their conjugation operons, suggesting potential advantages.