Review
Cell Biology
Jan Schick, Erez Raz
Summary: In the context of cell development, migration, and pathological conditions, cells commonly form protrusions called blebs. The inflation of blebs depends on actomyosin contraction, and they play an important role in cell locomotion. Different cells produce different forms of protrusions, with blebs being one of them.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Laura Bozal-Basterra, Maria Gonzalez-Santamarta, Veronica Muratore, Natalia Martin-Martin, Amaia Ercilla, Jose A. Rodriguez, Arkaitz Carracedo, James D. Sutherland, Rosa Barrio
Summary: LUZP1 exhibits frequent genomic aberrations in cancer, particularly gene deletions, and its loss promotes cell migration, invasion, apoptosis, and alterations in cell morphology. Additionally, LUZP1 plays regulatory roles beyond actin filament bundling, affecting actin polymerization through changes in ACTR3 and phospho-cofilin ratios. These findings suggest a novel role for LUZP1 in cancer regulation through actin cytoskeleton control.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Carsten Baltes, Divyendu Goud Thalla, Uli Kazmaier, Franziska Lautenschlaeger
Summary: Actin plays a crucial role in maintaining cell shape and generating forces. By stabilizing actin filaments with miuraenamide A, we observed a decrease in filament dynamics and an elongation of filament length, resulting in altered cell migration speed and nuclear position.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Emre Balta, Johanna Kramer, Yvonne Samstag
Summary: The actin cytoskeleton of eukaryotic cells is a dynamic fibrous network regulated by actin-binding proteins, playing a crucial role in cell polarization and migration. Protein oxidation studies provide insight into localized redox regulation of cellular functions, with a focus on the challenges and tools for physiological and pathophysiological consequences.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jianjiang Hu, Xiaowei Gong, Staffan Stromblad
Summary: Cells probe their microenvironment using membrane protrusion-retraction cycles. Spatial and temporal coordination between Rac1 and RhoA GTP-binding activities play critical roles in initiating and reinforcing protrusions and retractions. Rac1-GTP levels increase before protrusions, while RhoA-GTP levels increase before retractions. Rac1-GTP nadirs and peaks coincide with maximal edge velocity of local membrane protrusions and retractions, followed by declined edge velocity. The alteration of local Rac1-GTP precedes the alteration of traction force. Through optogenetic Rac1-GTP perturbations, we demonstrate the fundamental role of Rac1 in restricting the size and durability of protrusions and retractions, possibly through controlling traction forces.
Article
Allergy
Tania Gajardo, Mathilde Bernard, Marie Lo, Elisa Turck, Claire Leveau, Marie-Therese EI-Daher, Alexandre Deslys, Patricia Panikulam, Constantin Menche, Mathieu Kurowska, Gregoire Le Lay, Lucie Barbier, Despina Moshous, Benedicte Neven, Henner F. Farin, Alain Fischer, Gael Menasche, Genevieve de Saint Basile, Pablo Vargas, Fernando E. Sepulveda
Summary: This study investigates the impact of TTC7A deficiency on immune homeostasis and reveals that TTC7A-deficient lymphocytes exhibit altered cell migration and impaired actin dynamics. These findings suggest that TTC7A plays a critical role in lymphocyte migration and is likely to contribute to the progressive immunodeficiency in patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Cell Biology
Tarun Yadav, David Gau, Partha Roy
Summary: The interaction between mitochondria and the actin cytoskeleton is crucial for cellular physiology, including cell migration, and is also implicated in pathological events such as cancer metastasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Chao Xie, Yuxiang Jiang, Zhiwen Zhu, Shanjin Huang, Wei Li, Guangshuo Ou
Summary: The evolutionarily conserved coronin family protein POD-1 debranches Arp2/3-nucleated actin filaments in migrating neuroblasts and asymmetrically dividing embryos, contributing to cell polarity and migration. Fluorescence live imaging analysis revealed POD-1 colocalization with Arp2/3 at the leading edge of neuroblasts, indicating their synergistic role in organizing actin networks and cell polarity. Conditional mutations of POD-1 disrupted actin assembly, cell polarity, and migration, highlighting the importance of F-actin debranching in regulating these cellular processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Vera B. Dugina, Galina S. Shagieva, Anton S. Shakhov, Irina B. Alieva
Summary: Endothelial cells (EC) line the inner surface of vessels and regulate vascular permeability, with their actin cytoskeleton crucial for maintaining endothelial barrier function. Non-muscle cells express two actin isoforms, beta and gamma, which have different roles in cell survival, cell division, and neoplastic transformation depending on the cell type. The spatial organization of cytoplasmic actins in different cell types, particularly in endothelial cells, is closely linked to their functional activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mary Kho, Siarhei Hladyshau, Denis Tsygankov, Shuyi Nie
Summary: In this study, the role of septin filaments in cell migration was examined using highly migratory neural crest cells of frog embryos. Septin filaments were found to control both the speed and the direction of cell migration by interacting with actin stress fibers. Additionally, the activities of septin filaments were shown to depend on Cdc42ep1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Paulius Gibieza, Vilma Petrikaite
Summary: Broad studies of cancer have provided insights into the biological and environmental factors contributing to malignant cell transformation, as well as the role of RabGTPases in regulating cell division and tumorigenesis. Understanding these mechanisms may lead to new treatment strategies for cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Immunology
Brian J. Laidlaw, Jason G. Cyster
Summary: Memory B cells play a critical role in developing protective immunity and efforts to induce broadly protective MBCs to rapidly mutating pathogens with vaccines have been unsuccessful. Understanding the signals and transcription factors regulating MBC development and function are crucial for overcoming challenges in vaccine development.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Immunology
Jose Luis Rodriguez-Fernandez, Olga Criado-Garcia
Summary: Chemoattraction is the migration of cells towards a chemical gradient, controlled by chemoattractant receptors. Directional sensing and actin-based motility are the two basic activities involved in chemoattraction, and recent research suggests that they can be independently regulated.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Shengbo Zhang, Cindy Audiger, Michael Chopin, Stephen L. Nutt
Summary: This review summarizes recent advances in understanding the transcriptional networks that regulate the development of different subsets of dendritic cells (DCs). It discusses the heterogeneity of cDC2s, the ontogeny of pDCs, and the newly described DC subset, DC3. The review also examines critical transcription factors such as IRF8, PU.1, and E2-2, and highlights their regulatory mechanisms and downstream targets. The complex interplay between these transcription factors shapes the DC transcriptome and influences their function in response to environmental stimuli. The information presented in this review provides essential insights into the regulation of DC development and function, with potential implications for developing novel therapeutic strategies for immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Michael Lewis, Travis H. Stracker
Summary: The differentiation program of multiciliated cells is initiated by GEMC1 and MCIDAS, which activate key transcription factors to control the generation of multiple motile cilia. To support this, massive centriole amplification is required, along with the generation of unique deuterosomes and extensive remodeling of the cytoskeleton.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Nicola Ternette, Marloes J. M. Olde Nordkamp, Julius Mueller, Amanda P. Anderson, Annalisa Nicastri, Adrian V. S. Hill, Benedikt M. Kessler, Demin Li
Article
Multidisciplinary Sciences
Matthew K. O'Shea, Rachel Tanner, Julius Mueller, Stephanie A. Harris, Danny Wright, Lisa Stockdale, Elena Stylianou, Iman Satti, Steven G. Smith, James Dunbar, Thomas E. Fletcher, Martin Dedicoat, Adam F. Cunningham, Helen McShane
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O'Shea, Magali Matsumiya, Helen Lockstone, Julius Mueller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon
NATURE COMMUNICATIONS
(2018)
Article
Immunology
Matthew K. O'Shea, Thomas E. Fletcher, Julius Muller, Rachel Tanner, Magali Matsumiya, J. Wendi Bailey, Jayne Jones, Steven G. Smith, Gavin Koh, William G. Horsnell, Nicholas J. Beeching, James Dunbar, Duncan Wilson, Adam F. Cunningham, Helen McShane
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Doria Filipponi, Alexander Emelyanov, Julius Muller, Clement Molina, Jennifer Nichols, Dmitry V. Bulavin
Article
Biochemistry & Molecular Biology
Yazi D. Ke, Gabriella Chan, Kristie Stefanoska, Carol Au, Mian Bi, Julius Mueller, Magdalena Przybyla, Astrid Feiten, Emmanuel Prikas, Glenda M. Halliday, Olivier Piguet, Matthew C. Kiernan, Michael Kassiou, John R. Hodges, Clement T. Loy, John S. Mattick, Arne Ittner, Jillian J. Kril, Greg T. Sutherland, Lars M. Ittner
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Immunology
Mona O. Mohsen, Monique Vogel, Carsten Riether, Julius Muller, Silvia Salatinos, Nicola Ternette, Ariane C. Gomes, Gustavo Cabral-Miranda, Aadil El-Turabi, Christiane Ruedl, Thomas M. Kundig, Said Dermime, Alexander Knuth, Daniel E. Speiser, Martin F. Bachmann
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Medicine, Research & Experimental
Christoph J. Blohmke, Julius Muller, Malick M. Gibani, Hazel Dobinson, Sonu Shrestha, Soumya Perinparajah, Celina Jin, Harri Hughes, Luke Blackwell, Sabina Dongol, Abhilasha Karkey, Fernanda Schreiber, Derek Pickard, Buddha Basnyat, Gordon Dougan, Stephen Baker, Andrew J. Pollard, Thomas C. Darton
EMBO MOLECULAR MEDICINE
(2019)
Article
Immunology
Ariane C. Gomes, Mona O. Mohsen, Julius E. Mueller, Fabiana M. S. Leoratti, Gustavo Cabral-Miranda, Martin F. Bachmann
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Infectious Diseases
Susanne H. Hodgson, Julius Muller, Helen E. Lockstone, Adrian V. S. Hill, Kevin Marsh, Simon J. Draper, Julian C. Knight
Article
Immunology
Paulo Bettencourt, Julius Muller, Annalisa Nicastri, Daire Cantillon, Meera Madhavan, Philip D. Charles, Carine B. Fotso, Rachel Wittenberg, Naomi Bull, Nawamin Pinpathomrat, Simon J. Waddell, Elena Stylianou, Adrian V. S. Hill, Nicola Ternette, Helen McShane
Article
Clinical Neurology
Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Mueller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H. Stevens, John Power, Gary D. Housley, Tim Karl, Michael Kassiou, Yazi D. Ke, Arne Ittner, Lars M. Ittner
Article
Biochemical Research Methods
Annalisa Nicastri, Hanqing Liao, Julius Muller, Anthony W. Purcell, Nicola Ternette
Article
Immunology
Ying Du, Ethan G. Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A. van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff, Jenny Hendriks, Malcolm J. Gardner, W. Ripley Ballou, Jason A. Regules, Robbert van der Most, Alan Aderem, Christian F. Ockenhouse, Adrian Hill, Ulrike Wale-Reece, Daniel E. Zak
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Julius Muller, Rachel Tanner, Magali Matsumiya, Margaret A. Snowden, Bernard Landry, Iman Satti, Stephanie A. Harris, Matthew K. O'Shea, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington-Kandt, Zita-Rose Manjaly Thomas, Vivek Naranbhai, Elena Stylianou, Stanley Kimbung Mbandi, Mark Hatherill, Gregory Hussey, Hassan Mahomed, Michele Tameris, J. Bruce McClain, Thomas G. Evans, Willem A. Hanekom, Thomas J. Scriba, Helen McShane, Helen A. Fletcher
