Review
Oncology
Carmen Salguero-Aranda, Joaquin Olmedo-Pelayo, Enrique de alava, Ana Teresa Amaral, Juan Diaz-Martin
Summary: Cancer is a genetic disease caused by changes in genes controlling cell growth. The Hippo pathway, a developmental signaling system, plays a critical role in tissue and organ size regulation and is frequently deregulated in cancer. This article reviews the relevance of the Hippo pathway in specific sarcoma subtypes and discusses its genetic alterations and other molecular mechanisms involved in its deregulation. It also explores the potential for targeted therapy in sarcoma based on these alterations.
Article
Multidisciplinary Sciences
Maria Brooun, Willi Salvenmoser, Catherine Dana, Marius Sudol, Robert Steele, Bert Hobmayer, Helen McNeill
Summary: This study reveals the role of the Hippo pathway in regulating axis formation in cnidarian Hydra, suggesting its importance in early metazoan evolution.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Kepeng Che, Ajaybabu Pobbati, Caleb N. Seavey, Yuriy Fedorov, Anton A. Komar, Ashley Burtscher, Shuang Ma, Brian P. Rubin
Summary: In this study, the researchers identified a pharmacologically active small molecule called aurintricarboxylic acid (ATA) that can disrupt the formation of the TAZ-TEAD complex. They found that ATA inhibits TC/TEAD transcriptional activity and prevents anchorage-independent growth associated with dysregulated TAZ/TEAD activity.
Review
Cell Biology
Pasquale Sileo, Clemence Simonin, Patricia Melnyk, Marie-Christine Chartier-Harlin, Philippe Cotelle
Summary: This review discusses the Hippo pathway and Wnt pathway, their roles in cell proliferation, survival, and neurodegenerative diseases, and suggests possible therapeutic approaches.
Review
Cardiac & Cardiovascular Systems
Yasuhiro Maejima, Daniela Zablocki, Jihoon Nah, Junichi Sadoshima
Summary: The Hippo pathway and autophagy mutually regulate each other, profoundly affecting cardiomyocyte survival and death.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Zijun Qian, Xiaoting Tian, Yayou Miao, Xin Xu, Xuehua Cheng, Mengyi Wu, Yongchun Yu
Summary: This study demonstrates that Bufalin can inhibit the proliferation of lung cancer cells in vivo/in vitro by suppressing the Hippo-YAP pathway. The findings show that Bufalin promotes the binding of LATS and YAP, leading to increased YAP phosphorylation. Phosphorylated YAP is unable to enter the nucleus and activate the expression of downstream proliferation-related genes, while the retained YAP in the cytoplasm undergoes degradation. This study verifies the key role of YAP in stimulating lung cancer proliferation and identifies Bufalin as a potential anticancer drug target.
CELLULAR SIGNALLING
(2023)
Review
Biochemistry & Molecular Biology
Filippos Koinis, Evangelia Chantzara, Michael Samarinas, Anastasia Xagara, Zisis Kratiras, Vasiliki Leontopoulou, Athanasios Kotsakis
Summary: This article summarizes the role of the Hippo pathway in prostate cancer and identifies knowledge gaps that need to be addressed for the development of YAP-targeted treatment strategies.
Article
Developmental Biology
Vakil Ahmad, Gangadhar P. Vadla, Chiswili Yves Chabu
Summary: The study revealed that Syd/JIP3 is essential for regulating wing size in Drosophila and that its deficiency leads to ectopic cell death and smaller wings; Syd/JIP3 is stimulated by Yorkie/YAP and functions downstream of Diap1 to control growth; The findings provide insight into the link between JIP3 mutations and organ size defects in mammals, including in humans.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Khuchtumur Bum-Erdene, Mona K. Ghozayel, Mark J. Zhang, Giovanni Gonzalez-Gutierrez, Samy O. Meroueh
Summary: The study focuses on the regulation of the Hippo pathway through the interaction between TEAD and YAP1. A small molecule that inhibits the binding of TEAD4 to YAP1 was discovered based on the structure of flufenamic acid. Chloroacetamide electrophiles were used to identify new compounds that disrupt the interaction between TEADs and YAP1.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Wenjing Du, Zhao Tang, Fangyong Yang, Xijun Liu, Jingcheng Dong
Summary: The study demonstrated that icariin can alleviate bleomycin-induced pulmonary fibrosis in rats by inhibiting YAP, a core transcriptional regulator of the Hippo pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Samar Sayedyahossein, Louise Thines, David B. Sacks
Summary: The Hippo signaling pathway regulates various cellular processes, including cell proliferation, differentiation, migration, and mechanosensation. Calcium ion (Ca2+) has been found to influence core components of the Hippo pathway. However, the crosstalk between Ca2+ signaling and the Hippo pathway is not fully understood.
CELLULAR SIGNALLING
(2023)
Review
Cell Biology
Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: The Hippo-YAP signaling pathway plays critical roles in cell functions, interacts with the RUNX transcription factors in proliferation, differentiation, and cell fate determination, and contributes to development and tumorigenesis.
Review
Immunology
Ancheng Zheng, Qishan Chen, Li Zhang
Summary: The Hippo-YAP pathway plays an important role in cardiovascular diseases and is involved in regulating inflammatory cell infiltration and inflammatory cytokine activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wanyun Zuo, Na Liu, Yunhong Zeng, Zhenghui Xiao, Keke Wu, Fan Yang, Biao Li, Qingqing Song, Yunbin Xiao, Qiming Liu
Summary: In this study, luteolin was found to have a beneficial effect on pulmonary arterial hypertension, possibly through inhibiting the HIPPO-YAP/PI3K/AKT signaling pathway. Therefore, luteolin may become a promising candidate for the treatment of PAH.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Kelly Coffey
Summary: Prostate cancer is a common cancer in men, and targeting the Hippo pathway for new treatment approaches may help improve the management of this disease.
Article
Multidisciplinary Sciences
A. Flores, S. Sandoyal-Gonzalez, R. Takahashi, A. Krall, L. Sathe, L. Wei, C. Radu, J. Jolly, N. Graham, H. R. Christofk, W. E. Lowry
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Shubha Gururaja Rao, Piotr Bednarczyk, Atif Towheed, Kajol Shah, Priyanka Karekar, Devasena Ponnalagu, Haley N. Jensen, Sankar Addya, Beverly A. S. Reyes, Elisabeth J. Van Bockstaele, Adam Szewczyk, Douglas C. Wallace, Harpreet Singh
Article
Medicine, Research & Experimental
Devasena Ponnalagu, Ahmed Tafsirul Hussain, Rushi Thanawala, Jahnavi Meka, Piotr Bednarczyk, Yansheng Feng, Adam Szewczyk, Shubha GururajaRao, Jean C. Bopassa, Mahmood Khan, Harpreet Singh
Article
Multidisciplinary Sciences
Louise Huot, Simon George, Pierre-Alain Girard, Dany Severae, Nicolas Negre, Bernard Duvic
SCIENTIFIC REPORTS
(2019)
Review
Physiology
Shubha Gururaja Rao, Nee J. Patel, Harpreet Singh
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Cell Biology
Julie A. Dougherty, Nil Patel, Naresh Kumar, Shubha Gururaja Rao, Mark G. Angelos, Harpreet Singh, Chuanxi Cai, Mahmood Khan
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Fisheries
Louise Huot, Audrey Bigourdan, Sylvie Pages, Jean-Claude Ogier, Pierre-Alain Girard, Nicolas Negre, Bernard Duvic
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2020)
Article
Entomology
Sudeeptha Yainna, Nicolas Negre, Pierre J. Silvie, Thierry Brevault, Wee Tek Tay, Karl Gordon, Emmanuelle dAlencon, Thomas Walsh, Kiwoong Nam
Summary: This study investigated the resistance of fall armyworm populations to Bt and synthetic insecticides in different geographic areas, finding that resistance mutations were more widespread in invasive populations, resulting in susceptibility to Bt insecticides and resistance to synthetic insecticides in Chinese populations. This highlights the importance of monitoring insecticide resistance in invasive populations using genomic approaches and bioassay experiments.
Article
Biochemistry & Molecular Biology
Gael J. Kergoat, Paul Z. Goldstein, Bruno Le Ru, Robert L. Meagher, Alberto Zilli, Andrew Mitchell, Anne-Laure Clamens, Sylvie Gimenez, Jerome Barbut, Nicolas Negre, Emmanuelle D'Alencon, Kiwoong Nam
Summary: The genus Spodoptera consists of 31 species with varied host plant breadths, with some species being major economic pests. Comparative genomics studies have highlighted major adaptive changes in genetic architecture among different Spodoptera species. Recent population genomics studies provide insights into population structures, migration patterns, and invasion processes of two species.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch'ng, K. Mark Parnell, Nicolas M. Reinoso-Vizcaino, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, Micah A. Luftig
Summary: The study found that EBV infection directly induced temporal expression of MCT1 and MCT4 in B lymphocytes, with MCT1 being crucial for early B cell proliferation and MCT4 upregulation leading to acquired resistance to MCT1 antagonism in LCLs. Dual inhibition of MCT1/4 resulted in growth arrest and lactate buildup in LCLs, suggesting a potential therapeutic approach for targeting viral lymphomas associated with EBV and KSHV.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Oscar A. Campos, Narsis Attar, Chen Cheng, Maria Vogelauer, Nathan Mallipeddi, Stefan Schmollinger, Nedas Matulionis, Heather R. Christofk, Sabeeha S. Merchant, Siavash K. Kurdistani
Summary: This study reveals that histone H3-mediated Cu1+ toxicity is a major determinant of cellular functional pool of Fe-S clusters. Inadequate Fe-S cluster supply causes severe metabolic and growth defects. Decreasing Cu1+ abundance restores Fe-S cluster-dependent metabolism and growth.
Review
Developmental Biology
William B. Tu, Heather R. Christofk, Kathrin Plath
Summary: Diet plays a crucial role in maintaining health throughout life, influencing cell fate decisions, maintaining tissue homeostasis, and mitigating the effects of aging. This review highlights the impact of common diets and specific nutrients on cell fate decisions in both healthy and disease contexts, as well as the potential of new models, technologies, and resources to advance dietary approaches for promoting healthy development and improving disease treatments.
Article
Evolutionary Biology
Kiwoong Nam, Sandra Nhim, Stephanie Robin, Anthony Bretaudeau, Nicolas Negre, Emmanuelle D'Alencon
BMC EVOLUTIONARY BIOLOGY
(2020)
Article
Biology
Sylvie Gimenez, Heba Abdelgaffar, Gaelle Le Goff, Frederique Hilliou, Carlos A. Blanco, Sabine Haenniger, Anthony Bretaudeau, Fabrice Legeai, Nicolas Negre, Juan Luis Jurat-Fuentes, Emmanuelle d'Alencon, Kiwoong Nam
COMMUNICATIONS BIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Sumanta Kumar Goswami, Devasena Ponnalagu, Ahmed T. Hussain, Kajol Shah, Priyanka Karekar, Shubha Gururaja Rao, Andrea L. Meredith, Mahmood Khan, Harpreet Singh
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2019)