期刊
GENES & DEVELOPMENT
卷 26, 期 4, 页码 305-311出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.186189.111
关键词
acute myeloid leukemia; apoptosis; Mcl-1; Bcl-x(L)
资金
- [R01 DK59427]
- [CA69008]
Bcl-2, Bcl-xL, Mcl-1, and A1 are the predominant antiapoptotic members of the Bcl-2 family in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-xL for survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of Genes & Development (pp. 120-125) demonstrates that Mcl-1 is essential for development and survival of acute myelogenous leukemia cells. These results provide new impetus for the generation of selective Mcl-1 inhibitors.
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